Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Substance Use Disorders: full-pipeline trial registry
43 of 94 indexed Substance Use Disorders trials are currently recruiting.
Corpus placement: #143 of 28,707 conditions by registered trial count.
94 US clinical trials · 43 currently recruiting · #143 of 28,707 conditions by registered trial count
Substance Use Disorders: 94 US clinical trials tracked, 43 recruiting.
Substance Use Disorders is the subject of 94 registered US clinical trials on ClinicalTrials.gov, 43 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 6 of these trials.
Enrollment posture brief
Registry condition substance-use-disorders
OPEN 43 | RECR 46% | LATE 5 | EARLY 5 | RANK #143 | SPON 6
Volume-matched condition peers
Nearest open-share peer: Waldenstrom Macroglobulinemia (46% recruiting · 35 trials)
Substance Use Disorders lists 43 open slots (46% of 94 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Substance Use Disorders on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
-
Substance Use Disorders is recruiting above its size-band peers.
43 of 94 indexed trials (45.7%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
-
Sponsorship of Substance Use Disorders trials is spread across many organizations.
VA Office of Research and Development accounts for 6 of 94 trials (6.4%). 62 distinct sponsors appear on at least one study for this condition label.
-
Typical Substance Use Disorders enrolment sits around 120 participants.
Median target enrolment is 120 among the 94 trials that report a genuine target (sentinel values excluded). 42 of those (44.7%) plan for fewer than 100 participants.
-
Substance Use Disorders research is mostly interventional.
90 interventional and 4 observational studies make up this index (95.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
94 total, page 1 of 2
Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
Massachusetts General Hospital
NCT04296604
Project I Test: Implementing HIV Testing in Opioid Treatment Programs
Columbia University
NCT03135886
Shared Decision Making to Treat Or Prevent (STOP) HIV in Justice Populations (R33)
Yale University
NCT07223398
Emergency Medicine Peer Outreach Worker Engagement for Recovery
University of California, Los Angeles
NCT06320015
Implementation of a Patient-centered, Reproductive Planning Decision Support Tool (MyPath) Among Women With Substance Use Disorder in the Immediate Postpartum Period
University of Pittsburgh
NCT04939012
Syringe Service Based Telemedicine and Social Network Driven HIV Prevention Service Implementation
Johns Hopkins University
NCT06103370
Families Left Behind
RAND
NCT06854757
Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders
Evon Medics
NCT06434818
Testing Strategies to Improve Substance Misuse Prevention Research Use in State Policy Contexts
Penn State University
NCT06856148
The Collaborative Care PrTNER Study
Children's Hospital of Philadelphia
NCT06585631
Mitigating the Impact of Stigma and Shame Among People Living With HIV and Substance Use Disorders
Boston University
NCT05934305
Young Houston Emergency Opioid Engagement System
The University of Texas Health Science Center, Houston
NCT04811014
COPEWeb Training for Providers
VA Office of Research and Development
NCT05812131
Substance Use Treatment and Access to Resources (STARS) Project
University of Oklahoma
NCT04459000
STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking
Medical University of South Carolina
NCT06922617
Minds and Mentors Program- R33
University of Alabama, Tuscaloo
NCT05363371
Supporting Treatment Access and Recovery Through Linkage and Support
University of Massachusetts, Worcester
NCT05713695
The Oklahoma Parent-Child Assistance Program
University of Oklahoma
NCT05534568
Massed Prolonged Exposure for PTSD in Substance Use Treatment
Veterans Medical Research Foundation
NCT06296186
IMPOWR-ME Project 1: Trial of Yoga and Physical Therapy Onsite at Opioid Treatment Programs
Albert Einstein College of Medicine
NCT05492825
Written Exposure Therapy for Veterans With SUD and PTSD
VA Office of Research and Development
NCT05327504
Feasibility of Brief Behavioral Therapy for Insomnia (BBTI) in SUD Recovery
Johns Hopkins University
NCT05935735
The STop UNhealthy Substance Use Now Trial
Ohio State University
NCT06524232
Utilizing Battlefield Acupuncture to Treat Chronic Pain
Edith Nourse Rogers Memorial Veterans Hospital
NCT06128772
Development OF A Novel Peer Recovery Supporter Training Platform
Thrive Digital Health
NCT07044531
Temporal Interference Methods for Addiction Treatment
Indiana University
NCT07210268
Ketamine for Methamphetamine Use Disorder
University of Texas Southwestern Medical Center
NCT06496750
Contingency Management for Recovery Oriented Activities at Recovery Houses
Wayne State University
NCT05585203
Preconception Intervention for Incarcerated Women With Substance Use
St. Louis University
NCT05854836
Enhancing Prospective Thinking in Early Recovery
Indiana University
NCT05835921
Substance Use Prevention for Youth With Parents in Recovery
Brown University
NCT05397691
Evaluating a One-Year Version of the Parent-Child Assistance Program
University of Oklahoma
NCT06163651
Trauma Screening/Referral and Interpersonal Violence Prevention for Women with Substance Use Disorders
Clemson University
NCT06608979
Family Support Protocol for Adolescent Internalizing Disorders
The National Center on Addiction and Substance Abuse at Columbia University
NCT06413979
CARS: Cannabis and Alcohol Reduction Study
Medical University of South Carolina
NCT05486234
rTMS for Craving in Methamphetamine Use Disorder
Oregon Health and Science University
NCT03470480
Development and Evaluation of a Virtual Reality Tool for At-Risk Trauma-Exposed Young People
Medical University of South Carolina
NCT05816083
Supervision in Substance Use Disorder Treatment Programs
University of Arkansas
NCT07262372
A Randomized Controlled Trial of Digital CBT to Treat Addiction: Digital RITch®CBT vs. Standard CBT
University of Rochester
NCT05943171
HIV, Equity, and Addiction Training (HEAT) Program
University of Alabama at Birmingham
NCT06370481
Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)
InSightec
NCT04197921
Quantitative Xylazine Measurement in ED
Icahn School of Medicine at Mount Sinai
NCT06949605
Effectiveness of the SoundHeal Multi-Sensory Integrative Therapy Among Justice-Involved Youth
SoundHeal
NCT07364799
Improving Maternal Mental Health & SUD Screening and Treatment
Medical University of South Carolina
NCT05764213
Achieving Equity in Patient Outcome Reporting for Timely Assessments of Life With HIV and Substance Use
University of Chicago
NCT06682468
Integrated Care and Treatment for Severe Infectious Diseases and Substance Use Disorders Among Hospitalized Patients
Columbia University
NCT05688423
Peer Supported Collaborative Care Mental Health and Substance Use Disorder Care
Johns Hopkins University
NCT04601064
Harnessing Telemedicine to Improve Alcohol Use Disorder Outcomes in Primary Care Patients
University of Michigan
NCT05410561
Evaluation of RRFT for Co-occurring SUD and PTSD Among Teens
Medical University of South Carolina
NCT05384223
Socializing a Science-Based Digital Therapeutic for Substance Use Disorders
Square2 Systems
NCT05648786
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 3 |
| Phase 3 | 2 |
| Phase 4 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Substance Use Disorders records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Substance Use Disorders trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Substance Use Disorders page
94 registered trials, 43 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 43 Substance Use Disorders trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most Substance Use Disorders trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Substance Use Disorders condition card totals 94 registered trials; most-linked intervention Treatment as Usual; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.