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ClinicalTrials.gov 43 recruiting now official registry

Substance Use Disorders clinical trials

43 of 94 indexed Substance Use Disorders trials are currently recruiting.

94 US clinical trials · 43 currently recruiting

Substance Use Disorders is the subject of 94 registered US clinical trials on ClinicalTrials.gov, 43 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 6 of these trials.

The research picture

Substance Use Disorders has 94 registered US clinical trials, 43 of them open to new participants right now, about 46% of the total.

43
recruiting participants now
46%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
6
top sponsor: VA Office of Research and Development
Phase 12Phase 23Phase 32Phase 43

Active & Recent Trials

94 total, page 1 of 2

RECRUITING NA 600 participants

Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

Massachusetts General Hospital

NCT04296604

RECRUITING NA 418 participants

Project I Test: Implementing HIV Testing in Opioid Treatment Programs

Columbia University

NCT03135886

RECRUITING NA 400 participants

Shared Decision Making to Treat Or Prevent (STOP) HIV in Justice Populations (R33)

Yale University

NCT07223398

RECRUITING 400 participants

Emergency Medicine Peer Outreach Worker Engagement for Recovery

University of California, Los Angeles

NCT06320015

RECRUITING NA 400 participants

Implementation of a Patient-centered, Reproductive Planning Decision Support Tool (MyPath) Among Women With Substance Use Disorder in the Immediate Postpartum Period

University of Pittsburgh

NCT04939012

RECRUITING NA 360 participants

Syringe Service Based Telemedicine and Social Network Driven HIV Prevention Service Implementation

Johns Hopkins University

NCT06103370

RECRUITING NA 340 participants

Families Left Behind

RAND

NCT06854757

RECRUITING Phase 2 300 participants

Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders

Evon Medics

NCT06434818

RECRUITING NA 300 participants

Testing Strategies to Improve Substance Misuse Prevention Research Use in State Policy Contexts

Penn State University

NCT06856148

RECRUITING NA 275 participants

The Collaborative Care PrTNER Study

Children's Hospital of Philadelphia

NCT06585631

RECRUITING NA 256 participants

Mitigating the Impact of Stigma and Shame Among People Living With HIV and Substance Use Disorders

Boston University

NCT05934305

RECRUITING Phase 4 250 participants

Young Houston Emergency Opioid Engagement System

The University of Texas Health Science Center, Houston

NCT04811014

RECRUITING NA 248 participants

COPEWeb Training for Providers

VA Office of Research and Development

NCT05812131

RECRUITING NA 242 participants

Substance Use Treatment and Access to Resources (STARS) Project

University of Oklahoma

NCT04459000

RECRUITING NA 240 participants

STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking

Medical University of South Carolina

NCT06922617

RECRUITING NA 240 participants

Minds and Mentors Program- R33

University of Alabama, Tuscaloo

NCT05363371

RECRUITING NA 208 participants

Supporting Treatment Access and Recovery Through Linkage and Support

University of Massachusetts, Worcester

NCT05713695

RECRUITING NA 200 participants

The Oklahoma Parent-Child Assistance Program

University of Oklahoma

NCT05534568

RECRUITING NA 200 participants

Massed Prolonged Exposure for PTSD in Substance Use Treatment

Veterans Medical Research Foundation

NCT06296186

RECRUITING NA 180 participants

IMPOWR-ME Project 1: Trial of Yoga and Physical Therapy Onsite at Opioid Treatment Programs

Albert Einstein College of Medicine

NCT05492825

RECRUITING NA 170 participants

Written Exposure Therapy for Veterans With SUD and PTSD

VA Office of Research and Development

NCT05327504

RECRUITING NA 150 participants

Feasibility of Brief Behavioral Therapy for Insomnia (BBTI) in SUD Recovery

Johns Hopkins University

NCT05935735

RECRUITING NA 144 participants

The STop UNhealthy Substance Use Now Trial

Ohio State University

NCT06524232

RECRUITING NA 125 participants

Utilizing Battlefield Acupuncture to Treat Chronic Pain

Edith Nourse Rogers Memorial Veterans Hospital

NCT06128772

RECRUITING NA 120 participants

Development OF A Novel Peer Recovery Supporter Training Platform

Thrive Digital Health

NCT07044531

RECRUITING NA 120 participants

Temporal Interference Methods for Addiction Treatment

Indiana University

NCT07210268

RECRUITING Phase 2 120 participants

Ketamine for Methamphetamine Use Disorder

University of Texas Southwestern Medical Center

NCT06496750

RECRUITING NA 120 participants

Contingency Management for Recovery Oriented Activities at Recovery Houses

Wayne State University

NCT05585203

RECRUITING NA 90 participants

Preconception Intervention for Incarcerated Women With Substance Use

St. Louis University

NCT05854836

RECRUITING NA 88 participants

Enhancing Prospective Thinking in Early Recovery

Indiana University

NCT05835921

RECRUITING NA 80 participants

Substance Use Prevention for Youth With Parents in Recovery

Brown University

NCT05397691

RECRUITING NA 80 participants

Evaluating a One-Year Version of the Parent-Child Assistance Program

University of Oklahoma

NCT06163651

RECRUITING NA 60 participants

Trauma Screening/Referral and Interpersonal Violence Prevention for Women with Substance Use Disorders

Clemson University

NCT06608979

RECRUITING NA 60 participants

Family Support Protocol for Adolescent Internalizing Disorders

The National Center on Addiction and Substance Abuse at Columbia University

NCT06413979

RECRUITING NA 52 participants

CARS: Cannabis and Alcohol Reduction Study

Medical University of South Carolina

NCT05486234

RECRUITING NA 50 participants

rTMS for Craving in Methamphetamine Use Disorder

Oregon Health and Science University

NCT03470480

RECRUITING NA 50 participants

Development and Evaluation of a Virtual Reality Tool for At-Risk Trauma-Exposed Young People

Medical University of South Carolina

NCT05816083

RECRUITING NA 43 participants

Supervision in Substance Use Disorder Treatment Programs

University of Arkansas

NCT07262372

RECRUITING NA 40 participants

A Randomized Controlled Trial of Digital CBT to Treat Addiction: Digital RITch®CBT vs. Standard CBT

University of Rochester

NCT05943171

RECRUITING NA 30 participants

HIV, Equity, and Addiction Training (HEAT) Program

University of Alabama at Birmingham

NCT06370481

RECRUITING NA 29 participants

Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)

InSightec

NCT04197921

RECRUITING 15 participants

Quantitative Xylazine Measurement in ED

Icahn School of Medicine at Mount Sinai

NCT06949605

RECRUITING NA 12 participants

Effectiveness of the SoundHeal Multi-Sensory Integrative Therapy Among Justice-Involved Youth

SoundHeal

NCT07364799

ACTIVE NOT RECRUITING NA 10,473 participants

Improving Maternal Mental Health & SUD Screening and Treatment

Medical University of South Carolina

NCT05764213

ACTIVE NOT RECRUITING NA 900 participants

Achieving Equity in Patient Outcome Reporting for Timely Assessments of Life With HIV and Substance Use

University of Chicago

NCT06682468

ACTIVE NOT RECRUITING NA 480 participants

Integrated Care and Treatment for Severe Infectious Diseases and Substance Use Disorders Among Hospitalized Patients

Columbia University

NCT05688423

ACTIVE NOT RECRUITING NA 405 participants

Peer Supported Collaborative Care Mental Health and Substance Use Disorder Care

Johns Hopkins University

NCT04601064

ACTIVE NOT RECRUITING NA 300 participants

Harnessing Telemedicine to Improve Alcohol Use Disorder Outcomes in Primary Care Patients

University of Michigan

NCT05410561

ACTIVE NOT RECRUITING NA 212 participants

Evaluation of RRFT for Co-occurring SUD and PTSD Among Teens

Medical University of South Carolina

NCT05384223

ACTIVE NOT RECRUITING NA 189 participants

Socializing a Science-Based Digital Therapeutic for Substance Use Disorders

Square2 Systems

NCT05648786

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Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 3
Phase 3 2
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Substance Use Disorders Trial Landscape

94 indexed Substance Use Disorders studies · 43 recruiting (46%).

Phase mix: 5 late (III/IV) vs 5 early (I/II).

Top sponsor: VA Office of Research and Development (6 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Substance Use Disorders?

PlainTrial tracks 94 US clinical trials for Substance Use Disorders, of which 43 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Substance Use Disorders?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.