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Substance Use Disorders clinical trials
43 of 94 indexed Substance Use Disorders trials are currently recruiting.
94 US clinical trials · 43 currently recruiting
Substance Use Disorders is the subject of 94 registered US clinical trials on ClinicalTrials.gov, 43 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 6 of these trials.
The research picture
Substance Use Disorders has 94 registered US clinical trials, 43 of them open to new participants right now, about 46% of the total.
- 43
- recruiting participants now
- 46%
- of trials open to enrollment
- 5
- in Phase 3–4 (later-stage)
- 6
- top sponsor: VA Office of Research and Development
Active & Recent Trials
94 total, page 1 of 2
Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations
Massachusetts General Hospital
NCT04296604
Project I Test: Implementing HIV Testing in Opioid Treatment Programs
Columbia University
NCT03135886
Shared Decision Making to Treat Or Prevent (STOP) HIV in Justice Populations (R33)
Yale University
NCT07223398
Emergency Medicine Peer Outreach Worker Engagement for Recovery
University of California, Los Angeles
NCT06320015
Implementation of a Patient-centered, Reproductive Planning Decision Support Tool (MyPath) Among Women With Substance Use Disorder in the Immediate Postpartum Period
University of Pittsburgh
NCT04939012
Syringe Service Based Telemedicine and Social Network Driven HIV Prevention Service Implementation
Johns Hopkins University
NCT06103370
Families Left Behind
RAND
NCT06854757
Enhanced Digital-Chemosensory-Based Olfactory Training for Remote Management of Substance Use Disorders
Evon Medics
NCT06434818
Testing Strategies to Improve Substance Misuse Prevention Research Use in State Policy Contexts
Penn State University
NCT06856148
The Collaborative Care PrTNER Study
Children's Hospital of Philadelphia
NCT06585631
Mitigating the Impact of Stigma and Shame Among People Living With HIV and Substance Use Disorders
Boston University
NCT05934305
Young Houston Emergency Opioid Engagement System
The University of Texas Health Science Center, Houston
NCT04811014
COPEWeb Training for Providers
VA Office of Research and Development
NCT05812131
Substance Use Treatment and Access to Resources (STARS) Project
University of Oklahoma
NCT04459000
STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking
Medical University of South Carolina
NCT06922617
Minds and Mentors Program- R33
University of Alabama, Tuscaloo
NCT05363371
Supporting Treatment Access and Recovery Through Linkage and Support
University of Massachusetts, Worcester
NCT05713695
The Oklahoma Parent-Child Assistance Program
University of Oklahoma
NCT05534568
Massed Prolonged Exposure for PTSD in Substance Use Treatment
Veterans Medical Research Foundation
NCT06296186
IMPOWR-ME Project 1: Trial of Yoga and Physical Therapy Onsite at Opioid Treatment Programs
Albert Einstein College of Medicine
NCT05492825
Written Exposure Therapy for Veterans With SUD and PTSD
VA Office of Research and Development
NCT05327504
Feasibility of Brief Behavioral Therapy for Insomnia (BBTI) in SUD Recovery
Johns Hopkins University
NCT05935735
The STop UNhealthy Substance Use Now Trial
Ohio State University
NCT06524232
Utilizing Battlefield Acupuncture to Treat Chronic Pain
Edith Nourse Rogers Memorial Veterans Hospital
NCT06128772
Development OF A Novel Peer Recovery Supporter Training Platform
Thrive Digital Health
NCT07044531
Temporal Interference Methods for Addiction Treatment
Indiana University
NCT07210268
Ketamine for Methamphetamine Use Disorder
University of Texas Southwestern Medical Center
NCT06496750
Contingency Management for Recovery Oriented Activities at Recovery Houses
Wayne State University
NCT05585203
Preconception Intervention for Incarcerated Women With Substance Use
St. Louis University
NCT05854836
Enhancing Prospective Thinking in Early Recovery
Indiana University
NCT05835921
Substance Use Prevention for Youth With Parents in Recovery
Brown University
NCT05397691
Evaluating a One-Year Version of the Parent-Child Assistance Program
University of Oklahoma
NCT06163651
Trauma Screening/Referral and Interpersonal Violence Prevention for Women with Substance Use Disorders
Clemson University
NCT06608979
Family Support Protocol for Adolescent Internalizing Disorders
The National Center on Addiction and Substance Abuse at Columbia University
NCT06413979
CARS: Cannabis and Alcohol Reduction Study
Medical University of South Carolina
NCT05486234
rTMS for Craving in Methamphetamine Use Disorder
Oregon Health and Science University
NCT03470480
Development and Evaluation of a Virtual Reality Tool for At-Risk Trauma-Exposed Young People
Medical University of South Carolina
NCT05816083
Supervision in Substance Use Disorder Treatment Programs
University of Arkansas
NCT07262372
A Randomized Controlled Trial of Digital CBT to Treat Addiction: Digital RITch®CBT vs. Standard CBT
University of Rochester
NCT05943171
HIV, Equity, and Addiction Training (HEAT) Program
University of Alabama at Birmingham
NCT06370481
Exablate for LIFU Neuromodulation in Patients With Opioid Use Disorder (OUD) and/or Other Substance Use Disorders (SUDs)
InSightec
NCT04197921
Quantitative Xylazine Measurement in ED
Icahn School of Medicine at Mount Sinai
NCT06949605
Effectiveness of the SoundHeal Multi-Sensory Integrative Therapy Among Justice-Involved Youth
SoundHeal
NCT07364799
Improving Maternal Mental Health & SUD Screening and Treatment
Medical University of South Carolina
NCT05764213
Achieving Equity in Patient Outcome Reporting for Timely Assessments of Life With HIV and Substance Use
University of Chicago
NCT06682468
Integrated Care and Treatment for Severe Infectious Diseases and Substance Use Disorders Among Hospitalized Patients
Columbia University
NCT05688423
Peer Supported Collaborative Care Mental Health and Substance Use Disorder Care
Johns Hopkins University
NCT04601064
Harnessing Telemedicine to Improve Alcohol Use Disorder Outcomes in Primary Care Patients
University of Michigan
NCT05410561
Evaluation of RRFT for Co-occurring SUD and PTSD Among Teens
Medical University of South Carolina
NCT05384223
Socializing a Science-Based Digital Therapeutic for Substance Use Disorders
Square2 Systems
NCT05648786
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 3 |
| Phase 3 | 2 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Substance Use Disorders Trial Landscape
94 indexed Substance Use Disorders studies · 43 recruiting (46%).
Phase mix: 5 late (III/IV) vs 5 early (I/II).
Top sponsor: VA Office of Research and Development (6 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Substance Use Disorders?
PlainTrial tracks 94 US clinical trials for Substance Use Disorders, of which 43 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Substance Use Disorders?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.