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NCT07210268 · ClinicalTrials.gov registry record · NA

Temporal Interference Methods for Addiction Treatment

A NA study of Substance Use Disorders and Nicotine Use Disorder, sponsored by Indiana University.

Recruiting
Registry status
NA
Development phase
120
Enrollment target
1
Study location

NCT07210268 is a NA study of Substance Use Disorders and Nicotine Use Disorder that is actively recruiting participants, run by Indiana University. The registered enrollment target is 120 participants, below the 499-participant average among 93 other Substance Use Disorders trials with a reported enrollment target (76% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT07210268, a NA study of Substance Use Disorders and Nicotine Use Disorder, is actively recruiting participants, sponsored by Indiana University.

RECRUITING
Registry status
NA
Development phase
120 participants
Enrollment target
1
Study location

Study Summary

This clinical study is testing whether a new non-invasive brain stimulation method, called temporal interference (TI), can reduce nicotine cravings and usage in people who vape. TI delivers mild electrical currents to the scalp in a way that targets deep brain areas involved in addiction, without the need for surgery. In this randomized controlled trial, participants will be assigned to one of three groups: TI stimulation to the nucleus accumbens, TI stimulation to the anterior insula, or a placebo (sham) condition. Each participant will attend a single stimulation session after 8 hours of nicotine abstinence and will use a custom vape device that measures real-time nicotine inhalation. Craving levels will be reported during and after the session. The study aims to determine whether TI to the insula or nucleus accumbens is more effective at decreasing cravings and nicotine inhalation, and whether either is more effective than sham stimulation. For one week after the session, participants will use a smartphone app to track nicotine use and cravings. The primary hypothesis is that TI stimulation to deep brain regions will reduce both nicotine craving and actual use, immediately after stimulation and over the following week, compared to the sham condition.

Conditions Studied

Substance Use Disorders Nicotine Use Disorder

Interventions

  • DEVICE TI-NDBS
  • DEVICE Sham TI-NDBS

Study Locations (1)

Indiana

  • Indiana University - Bloomington

Trial Details

FieldValue
Enrollment Target 120 participants
Start Date 2026-01-22
Est. Completion 2027-02-27
Phase NA

Sponsor

Indiana University

890 total trials

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What the Registry Record Tells You About NCT07210268

The ClinicalTrials.gov registry entry for NCT07210268 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 120 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 499-participant average among 93 other Substance Use Disorders trials with a reported enrollment target (76% lower). The listed sponsor is Indiana University, which has 890 total studies on file at ClinicalTrials.gov.

The record links to 2 conditions, with Substance Use Disorders appearing as the primary indexed condition, and to 2 interventions - of which TI-NDBS is the first listed.

NCT07210268 reports 1 study location spanning 1 distinct geographic area - top geographies include Indiana.

Frequently Asked Questions

What is clinical trial NCT07210268 about?

NCT07210268 is a clinical study titled "Temporal Interference Methods for Addiction Treatment". This clinical study is testing whether a new non-invasive brain stimulation method, called temporal interference (TI), can reduce nicotine cravings and usage in people who vape. TI delivers mild electrical currents to the scalp in a way that targets deep brain areas involved in addiction, without th...

What is the current status of trial NCT07210268?

This trial is currently recruiting. It is a NA study. The enrollment target is 120 participants. The study started on 2026-01-22. Estimated completion is 2027-02-27.

What conditions does trial NCT07210268 study?

This clinical trial studies the following conditions: Substance Use Disorders, Nicotine Use Disorder.

What interventions are being tested in trial NCT07210268?

The interventions under investigation include: TI-NDBS (DEVICE), Sham TI-NDBS (DEVICE).

Who is sponsoring clinical trial NCT07210268?

This trial is sponsored by Indiana University, which has 890 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT07210268 being conducted?

This trial has 1 study location across Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.