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Substance Use Disorders clinical trials
43 of 94 indexed Substance Use Disorders trials are currently recruiting.
94 US clinical trials · 43 currently recruiting
Substance Use Disorders is the subject of 94 registered US clinical trials on ClinicalTrials.gov, 43 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 6 of these trials.
The research picture
Substance Use Disorders has 94 registered US clinical trials, 43 of them open to new participants right now, about 46% of the total.
- 43
- recruiting participants now
- 46%
- of trials open to enrollment
- 5
- in Phase 3–4 (later-stage)
- 6
- top sponsor: VA Office of Research and Development
Active & Recent Trials
94 total, page 2 of 2
Mortality Reductions Based on AUD/Heavy Alcohol Use, HIV Risk, and Cardiovascular Risk
NYU Langone Health
NCT05828849
Examining Feasibility and Acceptability of Telemedicine for Substance Use Disorder (SUD)
University of Michigan
NCT04768920
The Human Stress Response in a Simulated ED Setting
University of Arkansas
NCT04317482
Developing a Telehealth Model to Improve Treatment Access for Rural Veterans With Substance Use Disorders
VA Office of Research and Development
NCT05348317
EXHIT ENTRE Implementation Trial of High Intensity Versus Low Intensity Strategy
Gavin Bart
NCT04921787
Study of the Safety and Feasibility of Psilocybin in Adults With Methamphetamine Use Disorder
University of Wisconsin, Madison
NCT05322954
Enhancing Substance Use Treatment Services to Decrease Dropout and Improve Outpatient Treatment Utilization in Emerging Adults
UConn Health
NCT05374395
Parenting Intervention for Mothers With Substance Use Disorder
Boston Medical Center
NCT06489522
Computerized Substance Use and Depression Screening and Behavioral Treatment in HIV Primary Care
University of California, San Francisco
NCT03217058
Coaching Performance Driven Practice Change in the Context of Value Based Purchasing Under New York Medicaid
NYU Langone Health
NCT04632238
Improving Adolescent Health Outcomes Through Preventive Care Transformation
Indiana University
NCT02244138
Homeless Care Management App
University of Oklahoma
NCT03399500
Substance Abuse Self-Help Group Referral: Outcomes and Services Use
US Department of Veterans Affairs
NCT00105729
The Effect of a Contingency Management Intervention on Substance Use
VA Office of Research and Development
NCT00252512
Effectiveness of Peer-Delivered Trauma-Specific Treatment
University of New Mexi
NCT02081417
Project POINT: Effectiveness and Scalability of an Overdose Survivor Intervention
Indiana University
NCT03336268
RAE (Realize, Analyze, Engage)
ContinueYou
NCT05227339
ART-CHESS: A Mobile Health Application to Support People Living With HIV and Addiction
University of Wisconsin, Madison
NCT03873129
Sequenced vs. Integrated Delivery of Treatment for Adolescent Depression and SUD
Oregon Research Institute
NCT00680966
Cognitive Behavioral Therapy (CBT) for PTSD in Veterans With Co-Occurring SUDs
VA Office of Research and Development
NCT01357577
Prevention of Substance Use in Youth in Ukraine
University of Michigan
NCT02347644
Quetiapine Extended Release (XR) in Bipolar Patients With Comorbid Generalized Anxiety Disorder (GAD)
University Hospitals Cleveland Medical Center
NCT00671853
Contingency Management Using Smartphone App in Patients With SUD
BrightView
NCT04162132
Enhancing Prospective Thinking in Early Recovery (PARK)
Indiana University
NCT05908097
Inpatient Link to Addiction Recovery
Prisma Health-Upstate
NCT04098601
Barriers to Substance Use Disorder Recovery
Prisma Health-Upstate
NCT04098614
HCV Group Evaluation and Treatment Uptake (HCV GET-UP) Intervention
Montefiore Medical Center
NCT03242655
Linkage to Care for Persons with Hep C Infection
Carilion Clinic
NCT05397067
Improving Sleep to Reduce Risk for Substance Use Disorder
Florida State University
NCT03226132
Evaluating The Efficacy Of A Mind-Body Intervention In Overcoming Opioid Addiction
Ohio State University
NCT03791645
Individual vs. Group Community Reinforcement Training to Help Parents of Substance-using Treatment-refusing Youth
Oregon Research Institute
NCT01829789
Evaluating Supplementing Residential Substance Use Treatment With Written Exposure Therapy for Veterans With Post Traumatic Stress Disorder (PTSD) and Substance Use Disorders (SUD)
VA Office of Research and Development
NCT05536908
Planning a Multi-Level Intervention to Reduce Substance Use Stigma in HIV Prevention and Care
Wayne State University
NCT05925374
Written Exposure in Substance Treatment
Potomac Health Foundations
NCT06296940
Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder
University of Massachusetts, Worcester
NCT03526354
HIV+ Substance Users Released From Jail
University of Texas Southwestern Medical Center
NCT03834779
Home-based Continuing Care for Young Adults Leaving Residential Substance Abuse Treatment
Treatment Research Institute
NCT02152033
Addiction Treatment Outcome Monitoring Study
University of Washington
NCT04155385
Families With Substance Use and Psychosis: A Pilot Study
Mclean Hospital
NCT04284813
AWAITS: A Web-based E-health Application for Active Illicit Opioid Users
University of Cincinnati
NCT03402672
Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation
Boston Medical Center
NCT02845453
Treating Violence-related PTSD and Substance Risk in Low-income, Urban Adolescents
State University of New York at Buffalo
NCT03737383
Parenting Young Children in Pediatrics
University of Oregon
NCT06273228
Open Trial to Improve Retention in Care for Persons With HIV Who Use Substances
Brown University
NCT05101044
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 3 |
| Phase 3 | 2 |
| Phase 4 | 3 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Substance Use Disorders Trial Landscape
94 indexed Substance Use Disorders studies · 43 recruiting (46%).
Phase mix: 5 late (III/IV) vs 5 early (I/II).
Top sponsor: VA Office of Research and Development (6 trials), 9 others listed. 44 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Substance Use Disorders?
PlainTrial tracks 94 US clinical trials for Substance Use Disorders, of which 43 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Substance Use Disorders?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.