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Substance Use Disorders: full-pipeline trial registry
43 of 94 indexed Substance Use Disorders trials are currently recruiting.
Corpus placement: #143 of 28,707 conditions by registered trial count.
94 US clinical trials · 43 currently recruiting · #143 of 28,707 conditions by registered trial count
Substance Use Disorders: 94 US clinical trials tracked, 43 recruiting.
Substance Use Disorders is the subject of 94 registered US clinical trials on ClinicalTrials.gov, 43 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 6 of these trials.
Enrollment posture brief
Registry condition substance-use-disorders
OPEN 43 | RECR 46% | LATE 5 | EARLY 5 | RANK #143 | SPON 6
Volume-matched condition peers
Nearest open-share peer: Waldenstrom Macroglobulinemia (46% recruiting · 35 trials)
Substance Use Disorders lists 43 open slots (46% of 94 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Substance Use Disorders on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Substance Use Disorders is recruiting above its size-band peers.
43 of 94 indexed trials (45.7%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Substance Use Disorders trials is spread across many organizations.
VA Office of Research and Development accounts for 6 of 94 trials (6.4%). 62 distinct sponsors appear on at least one study for this condition label.
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Typical Substance Use Disorders enrolment sits around 120 participants.
Median target enrolment is 120 among the 94 trials that report a genuine target (sentinel values excluded). 42 of those (44.7%) plan for fewer than 100 participants.
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Substance Use Disorders research is mostly interventional.
90 interventional and 4 observational studies make up this index (95.7% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
94 total, page 2 of 2
Mortality Reductions Based on AUD/Heavy Alcohol Use, HIV Risk, and Cardiovascular Risk
NYU Langone Health
NCT05828849
Examining Feasibility and Acceptability of Telemedicine for Substance Use Disorder (SUD)
University of Michigan
NCT04768920
The Human Stress Response in a Simulated ED Setting
University of Arkansas
NCT04317482
Developing a Telehealth Model to Improve Treatment Access for Rural Veterans With Substance Use Disorders
VA Office of Research and Development
NCT05348317
EXHIT ENTRE Implementation Trial of High Intensity Versus Low Intensity Strategy
Gavin Bart
NCT04921787
Study of the Safety and Feasibility of Psilocybin in Adults With Methamphetamine Use Disorder
University of Wisconsin, Madison
NCT05322954
Enhancing Substance Use Treatment Services to Decrease Dropout and Improve Outpatient Treatment Utilization in Emerging Adults
UConn Health
NCT05374395
Parenting Intervention for Mothers With Substance Use Disorder
Boston Medical Center
NCT06489522
Computerized Substance Use and Depression Screening and Behavioral Treatment in HIV Primary Care
University of California, San Francisco
NCT03217058
Coaching Performance Driven Practice Change in the Context of Value Based Purchasing Under New York Medicaid
NYU Langone Health
NCT04632238
Improving Adolescent Health Outcomes Through Preventive Care Transformation
Indiana University
NCT02244138
Homeless Care Management App
University of Oklahoma
NCT03399500
Substance Abuse Self-Help Group Referral: Outcomes and Services Use
US Department of Veterans Affairs
NCT00105729
The Effect of a Contingency Management Intervention on Substance Use
VA Office of Research and Development
NCT00252512
Effectiveness of Peer-Delivered Trauma-Specific Treatment
University of New Mexi
NCT02081417
Project POINT: Effectiveness and Scalability of an Overdose Survivor Intervention
Indiana University
NCT03336268
RAE (Realize, Analyze, Engage)
ContinueYou
NCT05227339
ART-CHESS: A Mobile Health Application to Support People Living With HIV and Addiction
University of Wisconsin, Madison
NCT03873129
Sequenced vs. Integrated Delivery of Treatment for Adolescent Depression and SUD
Oregon Research Institute
NCT00680966
Cognitive Behavioral Therapy (CBT) for PTSD in Veterans With Co-Occurring SUDs
VA Office of Research and Development
NCT01357577
Prevention of Substance Use in Youth in Ukraine
University of Michigan
NCT02347644
Quetiapine Extended Release (XR) in Bipolar Patients With Comorbid Generalized Anxiety Disorder (GAD)
University Hospitals Cleveland Medical Center
NCT00671853
Contingency Management Using Smartphone App in Patients With SUD
BrightView
NCT04162132
Enhancing Prospective Thinking in Early Recovery (PARK)
Indiana University
NCT05908097
Inpatient Link to Addiction Recovery
Prisma Health-Upstate
NCT04098601
Barriers to Substance Use Disorder Recovery
Prisma Health-Upstate
NCT04098614
HCV Group Evaluation and Treatment Uptake (HCV GET-UP) Intervention
Montefiore Medical Center
NCT03242655
Linkage to Care for Persons with Hep C Infection
Carilion Clinic
NCT05397067
Improving Sleep to Reduce Risk for Substance Use Disorder
Florida State University
NCT03226132
Evaluating The Efficacy Of A Mind-Body Intervention In Overcoming Opioid Addiction
Ohio State University
NCT03791645
Individual vs. Group Community Reinforcement Training to Help Parents of Substance-using Treatment-refusing Youth
Oregon Research Institute
NCT01829789
Evaluating Supplementing Residential Substance Use Treatment With Written Exposure Therapy for Veterans With Post Traumatic Stress Disorder (PTSD) and Substance Use Disorders (SUD)
VA Office of Research and Development
NCT05536908
Planning a Multi-Level Intervention to Reduce Substance Use Stigma in HIV Prevention and Care
Wayne State University
NCT05925374
Written Exposure in Substance Treatment
Potomac Health Foundations
NCT06296940
Controlled Trial of Brexpiprazole For The Treatment of Co-occurring Schizophrenia and Substance Use Disorder
University of Massachusetts, Worcester
NCT03526354
HIV+ Substance Users Released From Jail
University of Texas Southwestern Medical Center
NCT03834779
Home-based Continuing Care for Young Adults Leaving Residential Substance Abuse Treatment
Treatment Research Institute
NCT02152033
Addiction Treatment Outcome Monitoring Study
University of Washington
NCT04155385
Families With Substance Use and Psychosis: A Pilot Study
Mclean Hospital
NCT04284813
AWAITS: A Web-based E-health Application for Active Illicit Opioid Users
University of Cincinnati
NCT03402672
Treatment With Quetiapine for Youth With Substance Use Disorders and Severe Mood Dysregulation
Boston Medical Center
NCT02845453
Treating Violence-related PTSD and Substance Risk in Low-income, Urban Adolescents
State University of New York at Buffalo
NCT03737383
Parenting Young Children in Pediatrics
University of Oregon
NCT06273228
Open Trial to Improve Retention in Care for Persons With HIV Who Use Substances
Brown University
NCT05101044
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 3 |
| Phase 3 | 2 |
| Phase 4 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Substance Use Disorders records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Substance Use Disorders trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Substance Use Disorders page
94 registered trials, 43 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 43 Substance Use Disorders trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- VA Office of Research and Development sponsors the most Substance Use Disorders trials on record, review their full trial history before evaluating a specific study. See VA Office of Research and Development's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Substance Use Disorders condition card totals 94 registered trials; most-linked intervention Treatment as Usual; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.