Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT05036226 · ClinicalTrials.gov registry record · Phase 1
COAST Therapy in Advanced Solid Tumors and Prostate Cancer
A Phase 1 study of Solid Tumor, Adult and Prostate Cancer Recurrent, sponsored by Medical University of South Carolina.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 76
- Enrollment target
- 1
- Study location
NCT05036226: Recruiting Phase 1 study of Solid Tumor, Adult and Prostate Cancer Recurrent, sponsored by Medical University of South Carolina.
NCT05036226 is a Phase 1 study of Solid Tumor, Adult and Prostate Cancer Recurrent that is actively recruiting participants, run by Medical University of South Carolina. The registered enrollment target is 76 participants, below the 189-participant average among 72 other Solid Tumor, Adult trials with a reported enrollment target (60% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05036226, a Phase 1 study of Solid Tumor, Adult and Prostate Cancer Recurrent, is actively recruiting participants, sponsored by Medical University of South Carolina.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 76 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this Phase I/II study is to determine the safety and effectiveness of up to 5 study drugs used together for the treatment of solid tumor cancers. The drugs are hydroxychloroquine, metformin, sirolimus, dasatinib and nelfinavir and are given orally.
Primary Outcome
Maximum dose achievable without dose limiting toxicities (DLT's)
Conditions Studied
Interventions
- COMBINATION_PRODUCT Hydroxychloroquine, Metformin, Sirolimus
- COMBINATION_PRODUCT Hydroxychloroquine, Metformin, Sirolimus, Dasatanib
- COMBINATION_PRODUCT Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir
- COMBINATION_PRODUCT Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir, Dasatinib
Study Locations (1)
South Carolina
- Medical University of South Carolina - Charleston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 76 participants |
| Start Date | 2022-03-03 |
| Est. Completion | 2027-05-21 |
| Phase | Phase 1 |
What NCT05036226 shows while recruiting
NCT05036226 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 76 participants, a relatively small participant target, below the 189-participant average among 72 other Solid Tumor, Adult trials with a reported enrollment target (60% lower).
The record links to 2 conditions, with Solid Tumor, Adult appearing as the primary indexed condition, and to 4 interventions - of which Hydroxychloroquine, Metformin, Sirolimus is the first listed.
NCT05036226 reports a single indexed study location in South Carolina.
Frequently Asked Questions
What is clinical trial NCT05036226 about?
NCT05036226 is a clinical study titled "COAST Therapy in Advanced Solid Tumors and Prostate Cancer". The purpose of this Phase I/II study is to determine the safety and effectiveness of up to 5 study drugs used together for the treatment of solid tumor cancers. The drugs are hydroxychloroquine, metformin, sirolimus, dasatinib and nelfinavir and are given orally.
What is the current status of trial NCT05036226?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 76 participants. The study started on 2022-03-03. Estimated completion is 2027-05-21.
What conditions does trial NCT05036226 study?
This clinical trial studies the following conditions: Solid Tumor, Adult, Prostate Cancer Recurrent.
What interventions are being tested in trial NCT05036226?
The interventions under investigation include: Hydroxychloroquine, Metformin, Sirolimus (COMBINATION_PRODUCT), Hydroxychloroquine, Metformin, Sirolimus, Dasatanib (COMBINATION_PRODUCT), Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir (COMBINATION_PRODUCT), Hydroxychloroquine, Metformin, Sirolimus, Nelfinavir, Dasatinib (COMBINATION_PRODUCT).
Who is sponsoring clinical trial NCT05036226?
This trial is sponsored by Medical University of South Carolina, which has 755 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05036226 being conducted?
This trial has 1 study location across South Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Solid Tumor, Adult
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05036226's enrollment target sits among peer trials
76 51st of 72 higher than 22 of 72 other Solid Tumor, Adult trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Solid Tumor, Adult trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Study of CRX100 as Monotherapy and in Combination With Pembrolizumab in Patients With Advanced Solid Malignancies
RECRUITING · Phase 1
-
Open-Label, Dose-Escalation With Expansion to Assess the Safety, Tolerability, and PK of TRE-515 in Subjects With Solid Tumors
RECRUITING · Phase 1
-
A Study of BI-1206 in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors
RECRUITING · Phase 1
-
Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
RECRUITING · Phase 1
-
Study Assessing MTD, Safety, Tolerability, PK and Anti-tumor Effects of LNS8801alone and With Pembrolizumab
RECRUITING · Phase 1
-
A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors
RECRUITING · Phase 1
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02615184 · 76 participants · Phase 2
A Study to Check the Safety of Dexlansoprazole and Learn If it Can Heal Erosive Esophagitis (EE) and Keep it Healed in Children 2 to 11 Years Old
- NCT02821741 · 76 participants · NA
Effects of External Ear Stimulation on Pain Perception and Mood
- NCT03019757 · 76 participants
Distinguishing Between Alzheimer's Disease, Lewy Body Dementia, and Parkinson's Disease
- NCT03353584 · 76 participants · NA
Effect of Virtual Reality Technology for Pain Management of Vaso-Occlusive Crisis in Patients With Sickle Cell Disease
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI