Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

First In Human Study of CX-2051 in Advanced Solid Tumors

NCT06265688 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this first-in-human study, CTMX-2051-101, is to characterize the safety, tolerability, and antitumor activity of CX-2051 as a monotherapy and in combination with bevacizumab in adult participants with advanced solid tumors.

Conditions Studied

Interventions

  • DRUG Bevacizumab
  • DRUG CX-2051

Study Locations (4)

Colorado

  • Sarah Cannon Research Institute at HealthONE — Denver

Massachusetts

  • Dana-Farber Cancer Institute — Boston

North Carolina

  • Carolina BioOncology Institute, PLLC — Huntersville

Tennessee

  • Sarah Cannon Research Institute, LLC — Nashville

Trial Details

FieldValue
Enrollment Target 160 participants
Start Date 2024-04-02
Est. Completion 2029-03-31
Phase Phase 1

Sponsor

CytomX Therapeutics

2 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06265688

The ClinicalTrials.gov registry entry for NCT06265688 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 160 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is CytomX Therapeutics, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Solid Tumor, Adult appearing as the primary indexed condition, and to 2 interventions — of which Bevacizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06265688 reports 4 study locations spanning 4 distinct geographic areas — top geographies include Colorado, Massachusetts, North Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06265688 about?

NCT06265688 is a clinical study titled "First In Human Study of CX-2051 in Advanced Solid Tumors". The purpose of this first-in-human study, CTMX-2051-101, is to characterize the safety, tolerability, and antitumor activity of CX-2051 as a monotherapy and in combination with bevacizumab in adult participants with advanced solid tumors.

What is the current status of trial NCT06265688?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 160 participants. The study started on 2024-04-02. Estimated completion is 2029-03-31.

What conditions does trial NCT06265688 study?

This clinical trial studies the following conditions: Solid Tumor, Adult. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06265688?

The interventions under investigation include: Bevacizumab (DRUG), CX-2051 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06265688?

This trial is sponsored by CytomX Therapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06265688 being conducted?

This trial has 4 study locations across Colorado, Massachusetts, North Carolina, Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial