Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
Study of eFT226 in Subjects With Selected Advanced Solid Tumor Malignancies
NCT04092673 · View on ClinicalTrials.gov ↗
Study Summary
This clinical trial is a Phase 1-2, open-label, sequential-group, dose-escalation and cohort-expansion study evaluating the safety, pharmacokinetics (PK), pharmacodynamics, and antitumor activity of Zotatifin (eFT226) in subjects with selected advanced solid tumor malignancies.
Conditions Studied
Interventions
- DRUG Trastuzumab
- DRUG Fulvestrant
- DRUG Abemaciclib
- DRUG Sotorasib
- DRUG eFT226
Study Locations (14)
California
- University of Southern California — Los Angeles
- Valkyrie Clinical Trials — Los Angeles
- Hoag Memorial Hospital Presbyterian — Newport Beach
- Stanford University — Palo Alto
New York
- Memorial Sloan Kettering Cancer Center- Commack — Commack
- Memorial Sloan Kettering Cancer Center- Westchester — Harrison
- Memorial Sloan Kettering Cancer Center- David H. Koch Center for Cancer Care — New York
Texas
- MD Anderson Cancer Center — Houston
- New Experimental Therapeutics of San Antonio - NEXT Oncology — San Antonio
Michigan
- START Midwest — Grand Rapids
Nevada
- Comprehensive Cancer Centers of Nevada — Las Vegas
New Jersey
- Memorial Sloan Kettering Cancer Center- Monmouth — Middletown
Ohio
- University of Toledo Medical Center — Toledo
Virginia
- Virginia Cancer Specialists — Fairfax
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2019-10-25 |
| Est. Completion | 2025-03-31 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04092673
The ClinicalTrials.gov registry entry for NCT04092673 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 30 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Effector Therapeutics, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Solid Tumor, Adult appearing as the primary indexed condition, and to 5 interventions — of which Trastuzumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04092673 reports 14 study locations spanning 8 distinct geographic areas — top geographies include California, New York, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04092673 about?
NCT04092673 is a clinical study titled "Study of eFT226 in Subjects With Selected Advanced Solid Tumor Malignancies". This clinical trial is a Phase 1-2, open-label, sequential-group, dose-escalation and cohort-expansion study evaluating the safety, pharmacokinetics (PK), pharmacodynamics, and antitumor activity of Zotatifin (eFT226) in subjects with selected advanced solid tumor malignancies.
What is the current status of trial NCT04092673?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 30 participants. The study started on 2019-10-25. Estimated completion is 2025-03-31.
What conditions does trial NCT04092673 study?
This clinical trial studies the following conditions: Solid Tumor, Adult. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04092673?
The interventions under investigation include: Trastuzumab (DRUG), Fulvestrant (DRUG), Abemaciclib (DRUG), Sotorasib (DRUG), eFT226 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04092673?
This trial is sponsored by Effector Therapeutics, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04092673 being conducted?
This trial has 14 study locations across California, Michigan, Nevada, New Jersey, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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