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NCT06462794 · ClinicalTrials.gov registry record · Phase 1
First In Human Study of CX-801 in Advanced Solid Tumors
A Phase 1 study of Solid Tumor, Adult, sponsored by CytomX Therapeutics.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 121
- Enrollment target
- 2
- Study locations
NCT06462794: Recruiting Phase 1 study of Solid Tumor, Adult, sponsored by CytomX Therapeutics.
NCT06462794 is a Phase 1 study of Solid Tumor, Adult that is actively recruiting participants, run by CytomX Therapeutics. The registered enrollment target is 121 participants, below the 189-participant average among 72 other Solid Tumor, Adult trials with a reported enrollment target (36% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06462794, a Phase 1 study of Solid Tumor, Adult, is actively recruiting participants, sponsored by CytomX Therapeutics.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 121 participants
- Enrollment target
- 2
- Study locations
Study Summary
The purpose of this first-in-human study, CTMX-801-101, is to characterize the safety, tolerability, and antitumor activity of CX-801 as monotherapy and in combination with pembrolizumab in adult participants with advanced solid tumors.
Primary Outcome
The number of participants experiencing a dose-limiting toxicity (DLT) as defined in the protocol, AEs (adverse events), and treatment-emergent adverse events (TEAEs) at any dose level
Conditions Studied
Interventions
- DRUG pembrolizumab
- DRUG CX-801
Study Locations (2)
California
- University of California San Francisco - San Francisco
Pennsylvania
- University of Pittsburgh Hillman Cancer Center - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 121 participants |
| Start Date | 2024-08-28 |
| Est. Completion | 2029-06-30 |
| Phase | Phase 1 |
What NCT06462794 shows while recruiting
NCT06462794 is an interventional study that assigns participants to a tested intervention. The registered 121 participants enrollment target is mid-sized for trials with a published cap, below the 189-participant average among 72 other Solid Tumor, Adult trials with a reported enrollment target (36% lower).
The record links to 1 condition, with Solid Tumor, Adult appearing as the primary indexed condition, and to 2 interventions - of which pembrolizumab is the first listed.
NCT06462794 reports a single indexed study location in California, Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT06462794 about?
NCT06462794 is a clinical study titled "First In Human Study of CX-801 in Advanced Solid Tumors". The purpose of this first-in-human study, CTMX-801-101, is to characterize the safety, tolerability, and antitumor activity of CX-801 as monotherapy and in combination with pembrolizumab in adult participants with advanced solid tumors.
What is the current status of trial NCT06462794?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 121 participants. The study started on 2024-08-28. Estimated completion is 2029-06-30.
What conditions does trial NCT06462794 study?
This clinical trial studies the following conditions: Solid Tumor, Adult.
What interventions are being tested in trial NCT06462794?
The interventions under investigation include: pembrolizumab (DRUG), CX-801 (DRUG).
Who is sponsoring clinical trial NCT06462794?
This trial is sponsored by CytomX Therapeutics, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06462794 being conducted?
This trial has 2 study locations across California, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Solid Tumor, Adult
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06462794's enrollment target sits among peer trials
121 35th of 72 higher than 38 of 72 other Solid Tumor, Adult trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Solid Tumor, Adult trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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