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Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors
NCT06625775 · View on ClinicalTrials.gov ↗
Study Summary
First in human study to evaluate the safety, tolerability, and pharmacokinetics (PK) of BBO-10203, a PI3Kα:RAS breaker, alone and in combination with other anti-cancer agents in patients with advanced solid tumors.
Conditions Studied
Interventions
- DRUG Trastuzumab
- DRUG Fulvestrant
- DRUG Ribociclib
- DRUG FOLFOX
- DRUG BBO-10203
Study Locations (20)
Texas
- SCRI at Mary Crowley — Dallas
- University of Texas Southwestern Medical Center — Dallas
- The University of Texas MD Anderson Cancer Center — Houston
- University of Texas San Antonio (UTSA) — San Antonio
California
- University of California Los Angeles — Los Angeles
- University of California San Diego Moores Cancer Center — San Diego
- UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco
Massachusetts
- Massachusetts General Hospital — Boston
- Dana-Farber Cancer Insitute — Boston
Missouri
- St. Lukes Hospital of Kansas City — Kansas City
- Washington University School of Medicine — St Louis
New York
- Columbia University Irving Medical Center — New York
- Memorial Sloan Kettering Cancer Center — New York
Florida
- Moffitt Cancer Center — Tampa
Indiana
- Indiana University Simon Comprehensive Cancer Center — Indianapolis
Tennessee
- SCRI Oncology Partners — Nashville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 392 participants |
| Start Date | 2024-10-29 |
| Est. Completion | 2028-11 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06625775
The ClinicalTrials.gov registry entry for NCT06625775 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 392 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics), which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 10 conditions, with Metastatic Breast Cancer appearing as the primary indexed condition, and to 5 interventions — of which Trastuzumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06625775 reports 20 study locations spanning 12 distinct geographic areas — top geographies include Texas, California, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06625775 about?
NCT06625775 is a clinical study titled "Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors". First in human study to evaluate the safety, tolerability, and pharmacokinetics (PK) of BBO-10203, a PI3Kα:RAS breaker, alone and in combination with other anti-cancer agents in patients with advanced solid tumors.
What is the current status of trial NCT06625775?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 392 participants. The study started on 2024-10-29. Estimated completion is 2028-11.
What conditions does trial NCT06625775 study?
This clinical trial studies the following conditions: Metastatic Breast Cancer, Solid Tumor, Adult, Metastatic Colorectal Cancer, Advanced Breast Cancer, Metastatic Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06625775?
The interventions under investigation include: Trastuzumab (DRUG), Fulvestrant (DRUG), Ribociclib (DRUG), FOLFOX (DRUG), BBO-10203 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06625775?
This trial is sponsored by TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics), which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06625775 being conducted?
This trial has 20 study locations across California, Florida, Indiana, Massachusetts, Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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