Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Sickle Cell Disease: early-phase trial registry
95 of 214 indexed Sickle Cell Disease trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #43 of 28,707 conditions by registered trial count.
214 US clinical trials · 95 currently recruiting · #43 of 28,707 conditions by registered trial count
Sickle Cell Disease: 214 US clinical trials tracked, 95 recruiting.
Sickle Cell Disease is the subject of 214 registered US clinical trials on ClinicalTrials.gov, 95 of them currently open to new participants. 14 are in Phase 3-4 (later-stage) and 87 in Phase 1-2 (earlier-stage). The most active sponsor is St. Jude Children's Research Hospital, running 17 of these trials.
Enrollment posture brief
Registry condition sickle-cell-disease
OPEN 95 | RECR 44% | LATE 14 | EARLY 87 | RANK #43 | SPON 17
Volume-matched condition peers
Nearest open-share peer: Acute Ischemic Stroke (44% recruiting · 27 trials)
Sickle Cell Disease lists 95 open slots (44% of 214 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Sickle Cell Disease on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Sickle Cell Disease is recruiting above its size-band peers.
95 of 214 indexed trials (44.4%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Sickle Cell Disease trials is spread across many organizations.
St. Jude Children's Research Hospital accounts for 17 of 214 trials (7.9%). 101 distinct sponsors appear on at least one study for this condition label.
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Most Sickle Cell Disease trials plan to enrol fewer than 100 people.
Median target enrolment is 50 among the 214 trials that report a genuine target (sentinel values excluded). 150 of those (70.1%) plan for fewer than 100 participants.
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Sickle Cell Disease research is mostly interventional.
160 interventional and 54 observational studies make up this index (74.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
214 total, page 5 of 5
CD34+Selection for Partially Matched Family or Matched Unrelated Adult Donor Transplant
New York Medical College
NCT01049854
Multi-Center Study of Iron Overload: Pilot Study
UCSF Benioff Children's Hospital Oakland
NCT01114776
Cognitive Rehabilitation in Sickle Cell Disease
Duke University
NCT01793740
Hydroxyurea and EPO in Sickle Cell Disease
Julia Xu
NCT05451940
HRV-B for Symptom Management in Sickle Cell Patients
Prisma Health-Upstate
NCT03383913
Sildenafil for Treatment of Priapism in Men With Sickle Cell Anemia
Johns Hopkins University
NCT00940901
Transplantation for Patients With Sickle Cell Disease From Mismatched Family Donors of Bone Marrow
Emory University
NCT02757885
Analysis of T-Cell Immune Reconstitution Following Allogeneic Hematopoietic BMT for Severe SCD
Emory University
NCT00228631
Quantitative MRI for Patients With Sickle Cell Disease Undergoing Hematopoietic Cell Transplant
University of Michigan
NCT03458897
A Study to Assess the Safety, Tolerability, and Efficacy of BIVV003 for Autologous Hematopoietic Stem Cell Transplantation in Patients With Severe Sickle Cell Disease
Sangamo Therapeutics
NCT03653247
Microvascular and Cardiac Dysfunction in Paroxysmal Nocturnal Hemoglobinuria and Sickle Cell Disease
Oregon Health and Science University
NCT01294891
Nitrous Oxide Analgesia Vaso-occlusive Crisis
Columbia University
NCT01891812
Hematopoietic Stem Cell Transplant for Sickle Cell Disease
Case Comprehensive Cancer Center
NCT02065596
Allogeneic Stem Cell Transplantation Following Chemotherapy in Patients With Hemoglobinopathies
Dana-Farber Cancer Institute
NCT00153985
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 39 |
| Phase 2 | 48 |
| Phase 3 | 11 |
| Phase 4 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Sickle Cell Disease records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Sickle Cell Disease trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Sickle Cell Disease page
214 registered trials, 95 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 95 Sickle Cell Disease trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- St. Jude Children's Research Hospital sponsors the most Sickle Cell Disease trials on record, review their full trial history before evaluating a specific study. See St. Jude Children's Research Hospital's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Sickle Cell Disease condition card totals 214 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.