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NCT04857983 · ClinicalTrials.gov registry record · Phase 2
Memantine Augmentation of Targeted Cognitive Training in Schizophrenia
A Phase 2 study of Schizophrenia and Schizoaffective Disorder, sponsored by University of California, San Diego.
- Completed
- Registry status
- Phase 2
- Development phase
- 62
- Enrollment target
- 1
- Study location
NCT04857983: Completed Phase 2 study of Schizophrenia and Schizoaffective Disorder, sponsored by University of California, San Diego.
NCT04857983 is a Phase 2 study of Schizophrenia and Schizoaffective Disorder that has completed, run by University of California, San Diego. The registered enrollment target is 62 participants, below the 219-participant average among 315 other Schizophrenia trials with a reported enrollment target (72% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04857983, a Phase 2 study of Schizophrenia and Schizoaffective Disorder, has completed, sponsored by University of California, San Diego.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 62 participants
- Enrollment target
- 1
- Study location
Study Summary
Treatment of schizophrenia currently includes antipsychotic medications and cognitive therapies which improve some symptoms, but do not sufficiently restore cognitive functioning or reduce psychosocial disability. We hypothesize that medications that specifically target sensory information processing deficits, rather than psychotic symptoms per se, will significantly enhance the benefits of a sensory-based targeted cognitive training (TCT) intervention in patients with schizophrenia. We will complete a randomized, double-blind clinical trial to: 1) confirm that the drug memantine augments TCT learning; 2) determine whether memantine enhances the clinical benefits from a full 30 session course of TCT vs. TCT plus placebo in antipsychotic- medicated schizophrenia patients, and 3) determine if memantine's enhancement of TCT is most effective in biomarker-defined subgroups of patients.
Primary Outcome
PANSS Total Score is the primary clinical outcome measured at baseline vs. post TCT session 10, 20 and 30 (approximately 16 weeks). The PANSS total score has a range 30-210, with higher scores indicating worse outcome.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Memantine
Study Locations (1)
California
- Clinical Teaching Facility (CTF B-403 at UCSD Medical Center) - San Diego
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 62 participants |
| Start Date | 2021-07-06 |
| Est. Completion | 2025-03-30 |
| Phase | Phase 2 |
What the finished NCT04857983 record still lists
NCT04857983 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 62 participants, a relatively small participant target, below the 219-participant average among 315 other Schizophrenia trials with a reported enrollment target (72% lower).
The record links to 2 conditions, with Schizophrenia appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT04857983 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT04857983 about?
NCT04857983 is a clinical study titled "Memantine Augmentation of Targeted Cognitive Training in Schizophrenia". Treatment of schizophrenia currently includes antipsychotic medications and cognitive therapies which improve some symptoms, but do not sufficiently restore cognitive functioning or reduce psychosocial disability. We hypothesize that medications that specifically target sensory information processin...
What is the current status of trial NCT04857983?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 62 participants. The study started on 2021-07-06. Estimated completion is 2025-03-30.
What conditions does trial NCT04857983 study?
This clinical trial studies the following conditions: Schizophrenia, Schizoaffective Disorder.
What interventions are being tested in trial NCT04857983?
The interventions under investigation include: Placebo (DRUG), Memantine (DRUG).
Who is sponsoring clinical trial NCT04857983?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04857983 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04857983's enrollment target sits among peer trials
62 186th of 315 higher than 130 of 315 other Schizophrenia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Schizophrenia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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