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ClinicalTrials.gov 76 recruiting now official registry

Schizophrenia clinical trials

76 of 318 indexed Schizophrenia trials are currently recruiting.

318 US clinical trials · 76 currently recruiting

Schizophrenia is the subject of 318 registered US clinical trials on ClinicalTrials.gov, 76 of them currently open to new participants. 90 are in Phase 3-4 (later-stage) and 87 in Phase 1-2 (earlier-stage). The most active sponsor is University of Maryland, Baltimore, running 14 of these trials.

The research picture

Schizophrenia has 318 registered US clinical trials, 76 of them open to new participants right now, about 24% of the total.

76
recruiting participants now
24%
of trials open to enrollment
90
in Phase 3–4 (later-stage)
14
top sponsor: University of Maryland, Baltimore
Phase 147Phase 240Phase 350Phase 440

Active & Recent Trials

318 total, page 4 of 7

COMPLETED Phase 1 218 participants

Trial to Evaluate the Effects of OPC-34712 on QT/QTc in Subjects With Schizophrenia or Schizoaffective Disorder

Otsuka Pharmaceutical Development & Commercialization

NCT01423916

COMPLETED Phase 4 198 participants

Comparison of Aripiprazole and Risperidone for the Treatment of People With First-Episode Psychosis

Northwell Health

NCT00320671

COMPLETED Phase 2 182 participants

A Study to Assess Safety and Efficacy of KarXT in Adult Patients With Schizophrenia

Karuna Therapeutics

NCT03697252

COMPLETED Phase 3 176 participants

Clinical Study Of Schizophrenia in Both Men and Women

GlaxoSmithKline

NCT00071747

COMPLETED NA 174 participants

Comparing Mobile Health (mHealth) and Clinic-Based Self-Management Interventions for Serious Mental Illness

Dartmouth-Hitchcock Medical Center

NCT02421965

COMPLETED NA 168 participants

Virtual Reality Job Interview Training in Severe Mental Illness

University of Michigan

NCT03049813

COMPLETED 165 participants

Biomarkers in First Episode Schizophrenia

NYU Langone Health

NCT02033382

COMPLETED Phase 2 164 participants

Dose-response Study to Evaluate Safety, Efficacy, and Pharmacokinetics of PF-00217830 Compared With Placebo in Acute Exacerbation of Schizophrenia

Pfizer

NCT00580125

COMPLETED Phase 2 164 participants

A Phase 2 Efficacy and Safety Study of TAK-063 in Participants With an Acute Exacerbation of Schizophrenia

Takeda

NCT02477020

COMPLETED NA 164 participants

Determining Metabolic Effects of Valproate and Antipsychotic Therapy

Washington University School of Medicine

NCT00167934

COMPLETED 159 participants

Dopamine Function and Reward Processing In Schizophrenia

National Institute on Drug Abuse (NIDA)

NCT01035996

COMPLETED Phase 1 151 participants

Trial to Study the Effect of CVL-231 on 24-Hour Ambulatory Blood Pressure in Participants With Schizophrenia

Cerevel Therapeutics

NCT05245539

COMPLETED Phase 2 150 participants

Work Activity Augmented by Cognitive Rehabilitation for Schizophrenia

VA Office of Research and Development

NCT00430560

COMPLETED NA 149 participants

A New Paradigm for Illness Monitoring and Relapse Prevention in Schizophrenia

Dartmouth-Hitchcock Medical Center

NCT01952041

COMPLETED Phase 2 145 participants

Efficacy, Safety, and Tolerability of AVP-786 for the Treatment of Residual Schizophrenia

Avanir Pharmaceuticals

NCT02477670

COMPLETED Phase 3 140 participants

Safety and Tolerability of Risperidone Implants

Braeburn Pharmaceuticals

NCT02773576

COMPLETED 139 participants

The Role of Dysmyelination in Cognitive Impairment of Psychotic Spectrum Disorders

NYU Langone Health

NCT03166098

COMPLETED Phase 3 131 participants

High-Dose Oral Ziprasidone Versus Conventional Dosing in Participants With Residual Schizophrenia Symptoms

Donald C. Goff, MD

NCT00403546

COMPLETED Phase 4 125 participants

Treatment for First-Episode Schizophrenia

Northwell Health

NCT00000374

COMPLETED NA 123 participants

Contingency Management of Alcohol Abuse in the Severely Mentally ILL

University of Washington

NCT01567943

COMPLETED NA 122 participants

Personalized and Scalable Cognitive Remediation Approaches

New York State Psychiatric Institute

NCT01945333

COMPLETED NA 122 participants

Cognitive-Behavioral Therapy in Veterans With Schizophrenia

VA Office of Research and Development

NCT00688259

COMPLETED 120 participants

Risk Perception in Drug-Dependent Adults With and Without Schizophrenia

National Institute on Drug Abuse (NIDA)

NCT01031563

COMPLETED NA 120 participants

Evaluation of A Statewide Program to Prevent Early Mortality and to Promote Fitness in Persons With SMI

Dartmouth-Hitchcock Medical Center

NCT02334280

COMPLETED NA 120 participants

Attention Shaping Procedures for Improving Psychosocial Skills Among Adults With Schizophrenia

University of Medicine and Dentistry of New Jersey

NCT00391677

COMPLETED Phase 3 120 participants

Study Comparing the Affect of Bifeprunox Vs Olanzapine on Weight During the Treatment of Outpatients With Schizophrenia.

Wyeth is now a wholly owned subsidiary of Pfizer

NCT00380224

COMPLETED Phase 1 119 participants

Study Investigating the Effect of Lu AF35700 on Cardiac Repolarization in Men and Women With Schizophrenia and Schizoaffective Disorder

H. Lundbeck A/S

NCT02901587

COMPLETED Phase 1 114 participants

Phase 1 TAK-041 First-in-Human Safety, Tolerability, and Pharmacokinetics Study

Neurocrine Biosciences

NCT02748694

COMPLETED NA 108 participants

Family Intervention for Mental Illness and Substance Abuse

Dartmouth-Hitchcock Medical Center

NCT00043693

COMPLETED Phase 3 107 participants

Olanzapine Versus Placebo in the Treatment of Adolescents With Schizophrenia

Eli Lilly and Company

NCT00051298

COMPLETED Phase 1 107 participants

A Study To Evaluate The Effect Of A Supratherapeutic Dose Of MK-8189 On The QTc Interval In Participants With Schizophrenia (MK-8189-019)

Merck Sharp & Dohme

NCT05893862

COMPLETED NA 106 participants

A Study of Strategies to Improve Schizophrenia Treatment

US Department of Veterans Affairs

NCT00156637

COMPLETED NA 105 participants

Improving Negative Symptoms & Community Engagement in Veterans With Schizophrenia

VA Office of Research and Development

NCT02469389

COMPLETED Phase 3 104 participants

D-Serine Treatment of Negative Symptoms and Cognitive Deficits in Schizophrenia

Yale University

NCT00237809

COMPLETED Phase 1 103 participants

Study of CAD-9303 in Subjects With Schizophrenia

Cadent Therapeutics

NCT04306146

COMPLETED Phase 4 101 participants

High Dose Lurasidone for Patients With Treatment Resistant Schizophrenia

Northwestern University

NCT01569659

COMPLETED NA 100 participants

A Self-Management Program for Adults With Both Schizophrenia and a Co-occurring Medical Condition

University of Maryland, Baltimore

NCT00525304

COMPLETED Phase 2 100 participants

Imaging of Brain Receptors in Healthy Volunteers and in Patients With Schizophrenia

National Institute of Mental Health (NIMH)

NCT00061789

COMPLETED Phase 2 97 participants

Nicotinic Receptors and Schizophrenia

University of Colorado, Denver

NCT01400477

COMPLETED Phase 1 96 participants

Safety and Tolerability Study of Lu AF35700 After Repeated Dosing in Patients With Schizophrenia

H. Lundbeck A/S

NCT02202226

COMPLETED Phase 4 90 participants

Naltrexone Treatment of Alcohol Abuse in Schizophrenia

State University of New York - Upstate Medical University

NCT00145847

COMPLETED Phase 1 88 participants

A Study of ALKS 9072 in Subjects With Chronic Stable Schizophrenia

Alkermes

NCT01493726

COMPLETED NA 88 participants

Examining Risk Factors for Atypical Antipsychotic Metabolic Side Effects

University of Michigan

NCT00815854

COMPLETED NA 87 participants

Mobile Self-Tracking of Mental Health

VA Office of Research and Development

NCT05023252

COMPLETED Phase 3 86 participants

Effectiveness of a Lifestyle Intervention for Increasing Physical Activity in Adults With Schizophrenia

Veterans Medical Research Foundation

NCT00338832

COMPLETED NA 85 participants

Luteolin for the Treatment of People With Schizophrenia

University of Maryland, Baltimore

NCT05204407

COMPLETED NA 83 participants

Oxytocin and CBSST for People With Schizophrenia

University of Maryland, Baltimore

NCT01752712

COMPLETED Phase 1 81 participants

Comparative Bioavailability of Risperidone

Rovi Pharmaceuticals Laboratories

NCT03527186

COMPLETED Phase 1 80 participants

Comparative Bioavailability of Risperidone.

Rovi Pharmaceuticals Laboratories

NCT05179525

COMPLETED NA 80 participants

Effects of Motivating People With Schizophrenia to Exercise

The University of Tennessee, Knoxville

NCT00559572

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Phase Distribution

PhaseTrial count
Phase 1 47
Phase 2 40
Phase 3 50
Phase 4 40

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Schizophrenia Trial Landscape

318 indexed Schizophrenia studies · 76 recruiting (24%).

Phase mix: 90 late (III/IV) vs 87 early (I/II).

Top sponsor: University of Maryland, Baltimore (14 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Schizophrenia?

PlainTrial tracks 318 US clinical trials for Schizophrenia, of which 76 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Schizophrenia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.