Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Rett Syndrome: full-pipeline trial registry
11 of 19 indexed Rett Syndrome trials are currently recruiting.
Corpus placement: #902 of 28,707 conditions by registered trial count.
19 US clinical trials · 11 currently recruiting · #902 of 28,707 conditions by registered trial count
Rett Syndrome: 19 US clinical trials tracked, 11 recruiting.
Rett Syndrome is the subject of 19 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Rett Syndrome Research Trust, running 3 of these trials.
Enrollment posture brief
Registry condition rett-syndrome
OPEN 11 | RECR 58% | LATE 3 | EARLY 4 | RANK #902 | SPON 3
Volume-matched condition peers
Nearest open-share peer: Burnout (58% recruiting · 19 trials)
Rett Syndrome lists 11 open slots (58% of 19 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Rett Syndrome on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Rett Syndrome is recruiting above its size-band peers.
11 of 19 indexed trials (57.9%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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One sponsor concentrates Rett Syndrome research.
Rett Syndrome Research Trust accounts for 3 of 19 trials (15.8%). 14 distinct sponsors appear on at least one study for this condition label.
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Most Rett Syndrome trials plan to enrol fewer than 100 people.
Median target enrolment is 50 among the 19 trials that report a genuine target (sentinel values excluded). 13 of those (68.4%) plan for fewer than 100 participants.
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Rett Syndrome splits between interventional and observational designs.
10 interventional and 9 observational studies make up this index (52.6% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
19 total, page 1 of 1
The Rett Syndrome Global Registry
Rett Syndrome Research Trust
NCT04900493
Rett Syndrome Registry
International Rett Syndrome Foundation
NCT05432349
To Investigate the Efficacy of Treatment With Oral NA-921 (Bionetide) Versus Placebo in Females With Rett Syndrome
Biomed Industries
NCT06840496
Neurophysiologic Biomarkers in Rett Syndrome
Children's Hospital of Philadelphia
NCT05932589
Web Intervention for Parents of Youth With Genetic Syndromes (WINGS)
Rush University Medical Center
NCT06139172
The Diagnostic Experience of Male Rett Syndrome
Children's Hospital Colorado
NCT06346106
A Novel, Regulated Gene Therapy (NGN-401) Study for Females With Rett Syndrome
Neurogene
NCT05898620
Validating Innovative Biosensors for Rett Autonomic Symptom Tracking
Rett Syndrome Research Trust
NCT06338267
Cognitive Function in Rett Syndrome During Trofinetide Treatment
University of Minnesota
NCT06705816
A Phase 1/2/3 Study of TSHA-102 Gene Therapy in Females With Rett Syndrome (REVEAL Pivotal Study)
Taysha Gene Therapies
NCT05606614
Measuring Impact of Computer Gaming on Arm Use in Rett Syndrome
Georgetown University
NCT05012475
Obi Medical Robot: Evaluating Effectiveness Related to Usability
Desin
NCT07151950
Technology-supported Motor Rehabilitation for People With Rett Syndrome
Georgetown University
NCT07418905
Safety and Efficacy of TSHA-102 in Pediatric Females With Rett Syndrome (REVEAL Pediatric Study)
Taysha Gene Therapies
NCT06152237
The Role of Family Functioning in Adaptation to Being a Caregiver of an Individual With Rett Syndrome
National Human Genome Research Institute (NHGRI)
NCT00891956
To Study the Efficacy & Safety of Oral NA-921 (Bionetide) in Girls and Women with Rett Syndrome
Biomed Industries
NCT06849973
Placebo Controlled Trial of Dextromethorphan in Rett Syndrome
Hugo W. Moser Research Institute at Kennedy Krieger
NCT01520363
ASSESSING EMERALD AND MC10 BIOSTAMP nPOINT BIOSENSORS FOR RETT SYNDROME
Rett Syndrome Research Trust
NCT04514549
Treatment of Rett Syndrome With rhIGF-1 (Mecasermin [rDNA]Injection)
Boston Children's Hospital
NCT01253317
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 2 |
| Phase 3 | 3 |
Top Sponsors
Named interventions
Most-linked intervention names on Rett Syndrome records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Rett Syndrome trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Rett Syndrome page
19 registered trials, 11 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 11 Rett Syndrome trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Rett Syndrome Research Trust sponsors the most Rett Syndrome trials on record, review their full trial history before evaluating a specific study. See Rett Syndrome Research Trust's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Rett Syndrome condition card totals 19 registered trials; most-linked intervention TSHA-102; top US site state Massachusetts. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.