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ACTIVE NOT RECRUITING Phase 2

Cediranib Maleate and Olaparib Compared to Bevacizumab in Treating Patients With Recurrent Glioblastoma

NCT02974621 · View on ClinicalTrials.gov ↗

Study Summary

This randomized phase II trial studies how well cediranib maleate and olaparib work compared to bevacizumab in treating patients with glioblastoma that has come back (recurrent). Cediranib maleate and olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as bevacizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

Conditions Studied

Interventions

  • DRUG Olaparib
  • BIOLOGICAL Bevacizumab
  • DRUG Cediranib
  • DRUG Cediranib Maleate

Study Locations (20)

Connecticut

  • Smilow Cancer Hospital-Derby Care Center — Derby
  • Smilow Cancer Hospital Care Center-Fairfield — Fairfield
  • Smilow Cancer Hospital Care Center - Guilford — Guilford
  • Smilow Cancer Hospital Care Center at Saint Francis — Hartford
  • Smilow Cancer Center/Yale-New Haven Hospital — New Haven
  • Yale University — New Haven
  • Smilow Cancer Hospital-Orange Care Center — Orange
  • Smilow Cancer Hospital-Torrington Care Center — Torrington
  • Smilow Cancer Hospital Care Center-Trumbull — Trumbull
  • Smilow Cancer Hospital-Waterbury Care Center — Waterbury
  • Smilow Cancer Hospital Care Center - Waterford — Waterford

Missouri

  • Siteman Cancer Center at Saint Peters Hospital — City of Saint Peters
  • Siteman Cancer Center at West County Hospital — Creve Coeur
  • Washington University School of Medicine — St Louis

Massachusetts

  • Massachusetts General Hospital Cancer Center — Boston
  • Dana-Farber Cancer Institute — Boston

California

  • UC San Diego Moores Cancer Center — La Jolla

Colorado

  • UCHealth University of Colorado Hospital — Aurora

Florida

  • Moffitt Cancer Center — Tampa

Kentucky

  • University of Kentucky/Markey Cancer Center — Lexington

Trial Details

FieldValue
Enrollment Target 70 participants
Start Date 2017-12-07
Est. Completion 2026-07-17
Phase Phase 2

Sponsor

National Cancer Institute (NCI)

2,390 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02974621

The ClinicalTrials.gov registry entry for NCT02974621 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 70 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Recurrent Glioblastoma appearing as the primary indexed condition, and to 4 interventions — of which Olaparib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02974621 reports 20 study locations spanning 7 distinct geographic areas — top geographies include Connecticut, Missouri, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02974621 about?

NCT02974621 is a clinical study titled "Cediranib Maleate and Olaparib Compared to Bevacizumab in Treating Patients With Recurrent Glioblastoma". This randomized phase II trial studies how well cediranib maleate and olaparib work compared to bevacizumab in treating patients with glioblastoma that has come back (recurrent). Cediranib maleate and olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth....

What is the current status of trial NCT02974621?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 70 participants. The study started on 2017-12-07. Estimated completion is 2026-07-17.

What conditions does trial NCT02974621 study?

This clinical trial studies the following conditions: Recurrent Glioblastoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02974621?

The interventions under investigation include: Olaparib (DRUG), Bevacizumab (BIOLOGICAL), Cediranib (DRUG), Cediranib Maleate (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02974621?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02974621 being conducted?

This trial has 20 study locations across California, Colorado, Connecticut, Florida, Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial