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ClinicalTrials.gov 29 recruiting now official registry

Recurrent Glioblastoma clinical trials

29 of 63 indexed Recurrent Glioblastoma trials are currently recruiting.

63 US clinical trials · 29 currently recruiting

Recurrent Glioblastoma is the subject of 63 registered US clinical trials on ClinicalTrials.gov, 29 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 54 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 7 of these trials.

The research picture

Recurrent Glioblastoma has 63 registered US clinical trials, 29 of them open to new participants right now, about 46% of the total.

29
recruiting participants now
46%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
7
top sponsor: National Cancer Institute (NCI)
Phase 137Phase 217Phase 32

Active & Recent Trials

63 total, page 2 of 2

COMPLETED Phase 2 137 participants

Bevacizumab With or Without Trebananib in Treating Patients With Recurrent Brain Tumors

National Cancer Institute (NCI)

NCT01609790

COMPLETED Phase 2 127 participants

A Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma

Celldex Therapeutics

NCT01498328

COMPLETED Phase 1 74 participants

Adavosertib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma

National Cancer Institute (NCI)

NCT01849146

COMPLETED Phase 1 67 participants

BGB-290 and Temozolomide in Treating Patients With Recurrent Gliomas With IDH1/2 Mutations

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT03914742

COMPLETED Phase 2 36 participants

Tremelimumab and Durvalumab in Combination or Alone in Treating Patients With Recurrent Malignant Glioma

Northwestern University

NCT02794883

COMPLETED Phase 1 30 participants

Feasibility of Individualized Therapy for Recurrent Glioblastoma

Jennifer Clarke

NCT03681028

COMPLETED Phase 1 29 participants

Lapatinib Ditosylate Before Surgery in Treating Patients With Recurrent High-Grade Glioma

National Cancer Institute (NCI)

NCT02101905

COMPLETED Phase 2 25 participants

LUMINOS-101: Lerapolturev (PVSRIPO) and Pembrolizumab in Patients With Recurrent Glioblastoma

Istari Oncology

NCT04479241

COMPLETED Phase 1 14 participants

ASP8374 + Cemiplimab in Recurrent Glioma

Dana-Farber Cancer Institute

NCT04826393

COMPLETED Phase 2 14 participants

Regorafenib in Bevacizumab Refractory Recurrent Glioblastoma

Case Comprehensive Cancer Center

NCT04051606

COMPLETED NA 14 participants

Mathematical Model-Adapted Radiation In Glioblastoma

Dana-Farber Cancer Institute

NCT03557372

COMPLETED Phase 1 12 participants

BPM31510 in Treating Patients With Recurrent High-Grade Glioma Previously Treated With Bevacizumab

Seema Nagpal

NCT03020602

COMPLETED Phase 1 8 participants

STAT3 Inhibitor WP1066 in Treating Patients With Recurrent Malignant Glioma or Progressive Metastatic Melanoma in the Brain

M.D. Anderson Cancer Center

NCT01904123

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Phase Distribution

PhaseTrial count
Phase 1 37
Phase 2 17
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Recurrent Glioblastoma Trial Landscape

63 indexed Recurrent Glioblastoma studies · 29 recruiting (46%).

Phase mix: 2 late (III/IV) vs 54 early (I/II).

Top sponsor: National Cancer Institute (NCI) (7 trials), 9 others listed. 13 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Recurrent Glioblastoma?

PlainTrial tracks 63 US clinical trials for Recurrent Glioblastoma, of which 29 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Recurrent Glioblastoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.