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ACTIVE NOT RECRUITING Phase 1

Genetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma

NCT02208362 · View on ClinicalTrials.gov ↗

Study Summary

This phase I trial studies the side effects and best dose of genetically modified T-cell immunotherapy in treating patients with malignant glioma that has come back (recurrent) or has not responded to therapy (refractory). A T cell is a type of immune cell that can recognize and kill abnormal cells in the body. T cells are taken from the patient's blood and a modified gene is placed into them in the laboratory and this may help them recognize and kill glioma cells. Genetically modified T-cells may also help the body build an immune response against the tumor cells.

Interventions

  • BIOLOGICAL Arm 1: IL13Ra2-specific CAR Tcm cells
  • BIOLOGICAL Arm 2: IL13Ra2-specific CAR Tcm cells
  • BIOLOGICAL Arm 3: IL13Ra2-specific CAR Tcm cells
  • BIOLOGICAL Arm 4: IL13Ra2-specific CAR Tcm cells
  • BIOLOGICAL Arm 5: IL13Ra2-specific CAR Tn/mem cells

Study Locations (1)

California

  • City of Hope Medical Center — Duarte

Trial Details

FieldValue
Enrollment Target 65 participants
Start Date 2015-05-18
Est. Completion 2026-06-08
Phase Phase 1

Sponsor

City of Hope Medical Center

771 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02208362

The ClinicalTrials.gov registry entry for NCT02208362 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 65 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is City of Hope Medical Center, which has 771 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 8 conditions, with Recurrent Glioblastoma appearing as the primary indexed condition, and to 5 interventions — of which Arm 1: IL13Ra2-specific CAR Tcm cells is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02208362 reports 1 study location spanning 1 distinct geographic area — top geographies include California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02208362 about?

NCT02208362 is a clinical study titled "Genetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma". This phase I trial studies the side effects and best dose of genetically modified T-cell immunotherapy in treating patients with malignant glioma that has come back (recurrent) or has not responded to therapy (refractory). A T cell is a type of immune cell that can recognize and kill abnormal cells ...

What is the current status of trial NCT02208362?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 65 participants. The study started on 2015-05-18. Estimated completion is 2026-06-08.

What conditions does trial NCT02208362 study?

This clinical trial studies the following conditions: Recurrent Glioblastoma, Recurrent Malignant Glioma, Recurrent WHO Grade III Glioma, Recurrent WHO Grade II Glioma, Refractory Glioblastoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02208362?

The interventions under investigation include: Arm 1: IL13Ra2-specific CAR Tcm cells (BIOLOGICAL), Arm 2: IL13Ra2-specific CAR Tcm cells (BIOLOGICAL), Arm 3: IL13Ra2-specific CAR Tcm cells (BIOLOGICAL), Arm 4: IL13Ra2-specific CAR Tcm cells (BIOLOGICAL), Arm 5: IL13Ra2-specific CAR Tn/mem cells (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02208362?

This trial is sponsored by City of Hope Medical Center, which has 771 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02208362 being conducted?

This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial