Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Rectal Cancer clinical trials
Every US clinical trial registered for Rectal Cancer — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
72 US clinical trials · 32 currently recruiting
The research picture
Rectal Cancer has 72 registered US clinical trials, 32 of them open to new participants right now — about 44% of the total.
- 32
- recruiting participants now
- 44%
- of trials open to enrollment
- 4
- in Phase 3–4 (later-stage)
- 8
- top sponsor: Memorial Sloan Kettering Cancer Center
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Integrated Cancer Repository for Cancer Research
University of Nebraska
NCT02012699
Sample Collection for Ongoing Research and Product Evaluation Study
Natera
NCT07318051
Improving Nutrition and Physical Activity for Cancer Survivors (Tools To Be Fit)
University of California, San Francis
NCT05056077
Washington University Participant Engagement and Cancer Genomic Sequencing Center (WU-PE-CGS)
Washington University School of Medicine
NCT06340646
A Study of Botensilimab and Balstilimab for Colorectal Cancer With ctDNA+ After Surgery and Chemotherapy
Memorial Sloan Kettering Cancer Center
NCT07227636
Resilience and Equity in Aging, Cancer, and Health (REACH)
Dana-Farber Cancer Institute
NCT04674267
Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer
Canadian Cancer Trials Group
NCT06205485
Efficacy and Safety of the CG-100 Intraluminal Bypass Device
Colospan
NCT04184973
A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression
A2 Biotherapeutics
NCT06682793
EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.
Case Comprehensive Cancer Center
NCT06263088
Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With/Without BMX-001
University of Nebraska
NCT05254327
Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients
National Cancer Institute (NCI)
NCT03190941
Ultrasound and Photoacoustic Imaging for Enhanced Differential Diagnosis of Rectal Cancer
Washington University School of Medicine
NCT04339374
An Informational and Supportive Care Intervention for Patients With Locally Advanced Rectal Cancer
Massachusetts General Hospital
NCT05914766
A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (mCRC)
SCRI Development Innovations
NCT07011576
Total Neoadjuvant Therapy With mFOLFOX and Short-course Radiation in Resectable Rectal Cancer
Virginia Commonwealth University
NCT04643366
High-Fermented Food Intervention Among Locally Advanced Rectal Cancer Patients (The FEED Trial)
H. Lee Moffitt Cancer Center and Research Institute
NCT06337552
Feasibility of Non-Operative Management of Rectal Cancer in a Rural Population
Bassett Healthcare
NCT04245683
Sequential TAS-OX Alternating With TAS-IRI Plus Bevacizumab for Late-Line Metastatic Colorectal Cancer
Rutgers, The State University of New Jersey
NCT05806931
Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer
Washington University School of Medicine
NCT03516708
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
University of Colorado, Denver
NCT07292298
A Phase I-II Study to Test the Safety and Efficacy of PD1 (AB122) and Adenosine Receptor (AB928) Antagonists With Chemotherapy After Short-Course Radiation for Rectal Cancer.
Weill Medical College of Cornell University
NCT05024097
The Impact of PReOPerative Exercise and NutritionaL Optimization on Perioperative Outcomes for Patients Undergoing Treatment for Rectal Cancer: The PROPEL Trial
Dana-Farber Cancer Institute
NCT06565052
A Study of Tucatinib and Trastuzumab in People With Rectal Cancer
Memorial Sloan Kettering Cancer Center
NCT05672524
Exosomes in Rectal Cancer
University of Kansas Medical Center
NCT03874559
Watchful Waiting for Complete Responders to Therapy in Rectal Cancer
Henry Ford Health System
NCT05526079
Evaluating a Nonessential Amino Acid Restriction (NEAAR) Medical Food With Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer (LARC)
University of South Florida
NCT06380101
A Study of Response to Standard Treatment Before Surgery in People With Rectal Cancer
Memorial Sloan Kettering Cancer Center
NCT06637462
Ultra-fractionated Radiotherapy for Rectal Cancer
University of Texas Southwestern Medical Center
NCT04677413
The Radiation Oncology-Biology Integration Network (ROBIN) Molecular Characterization Trial (MCT) of Standard Short Course Radiotherapy for Rectal Cancer
Weill Medical College of Cornell University
NCT05943210
F-Tryptophan PET/CT in Human Cancers
Barbara Ann Karmanos Cancer Institute
NCT05556473
Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women
Washington University School of Medicine
NCT06904365
Genomic Structural Variation in Cancer Susceptibility
Memorial Sloan Kettering Cancer Center
NCT00996710
Rectal Cancer And Pre-operative Induction Therapy Followed by Dedicated Operation. The RAPIDO Trial
University Medical Center Groningen
NCT01558921
Trial Evaluating 3-year Disease Free Survival in Patients With Locally Advanced Rectal Cancer Treated With Chemoradiation Plus Induction or Consolidation Chemotherapy and Total Mesorectal Excision or Non-operative Management
Memorial Sloan Kettering Cancer Center
NCT02008656
Supportive Oncology Care At Home RCT
Massachusetts General Hospital
NCT04544046
CRC Detection Reliable Assessment With Blood
New Day Diagnostics
NCT05551052
Relationship Between Quality of Life, Treatment Modalities, and Patient Treatment/Outcome Expectations
M.D. Anderson Cancer Center
NCT00648635
RCT of Mobile Apps & FitBit v. Usual Care
Weill Medical College of Cornell University
NCT03623464
Multicenter Phase II Study of Transanal TME (taTME)
Icahn School of Medicine at Mount Sinai
NCT03144765
The Exercise And Colorectal Cancer Treatment Trial
Pennington Biomedical Research Center
NCT03975491
Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer
University of Colorado, Denver
NCT04963283
Microbiome and Rectal Cancer
University of South Florida
NCT04223102
Transanal Total Mesorectal Excision for Rectal Cancer on Anal Physiology + Fecal Incontinence
Case Comprehensive Cancer Center
NCT03283540
Copper Cu 64 Anti-CEA Monoclonal Antibody M5A PET in Diagnosing Patients With CEA Positive Cancer
City of Hope Medical Center
NCT02293954
Early Phase Clinical Trial About Therapeutic Biological Product Mix for Treating CEA Positive Rectal Cancer
Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair
NCT02403505
Organ Preservation in Early Rectal Cancer Patients
Fox Chase Cancer Center
NCT03548961
A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Effectiveness of GSK4418959 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors
GlaxoSmithKline
NCT06710847
General Surgical Outcomes Quality Improvement Database (UH-SOCRATES)
University Hospitals Cleveland Medical Center
NCT00622557
Adherence to Colon Cancer Screening (ACCS)
Ohio State University Comprehensive Cancer Center
NCT02112747
Negative Pressure Therapy in Preventing Infection After Surgery in Patients With Colon, Rectal, Pancreatic, or Peritoneal Surface Cancer
Wake Forest University Health Sciences
NCT01656044
Patient Activation Intervention in Improving Screening Rates for Colorectal Cancer
Ohio State University Comprehensive Cancer Center
NCT01801059
A Study of LY2880070 in Participants With Advanced or Metastatic Cancer
Esperas Pharma
NCT02632448
Phase 1b/2 Study of AMG 655 With mFOLFOX6 and Bevacizumab for First-Line Metastatic Colorectal Cancer
Amgen
NCT00625651
The Sexual Health of Rectal Cancer Patients
Memorial Sloan Kettering Cancer Center
NCT00712751
GI SPORE Colon Biosample Protocol
University of Michigan
NCT02243267
Evaluating The Response to Pre-Operative Chemotherapy and/or Radiation Therapy For Rectal Cancer Using Three-Dimension Transrectal Ultrasound
Memorial Sloan Kettering Cancer Center
NCT00597610
An Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy
Corewell Health West
NCT00467922
5-Fluorouracil, Bevacizumab, and Radiation Followed by Modified FOLFOX6 and Bevacizumab in Stage II/III Rectal Cancer
SCRI Development Innovations
NCT00308516
Computer-Based Comprehensive Geriatric Assessment in Oncology for Individuals 70 or Older With Gastrointestinal Malignancies
Dana-Farber Cancer Institute
NCT00973440
CB-839 + Capecitabine in Solid Tumors and Fluoropyrimidine Resistant PIK3CA Mutant Colorectal Cancer
David Bajor, MD
NCT02861300
Clinical Trial in Patients With Metastatic Colorectal Cancer
Mast Therapeutics
NCT00081627
Promoting Physical Activity After Colorectal Cancer
The Miriam Hospital
NCT00230646
5-FU, Aflibercept, and Radiation (RT) for Preoperative and Postoperative Patients With Stage II/III Rectal Cancer
SCRI Development Innovations
NCT01749956
Neoadjuvant Chemoradiation With RHUMAB VEGF (Avastin) for Rectal Cancer
M.D. Anderson Cancer Center
NCT00113230
Non-Operative Radiation Management of Adenocarcinoma of the Lower Rectum
Washington University School of Medicine
NCT02641691
Clinical and Translational Study of STA-9090
Memorial Sloan Kettering Cancer Center
NCT01111838
Cellular Immune Augmentation in Colon and Rectal Cancer
University of California, Irvine
NCT00257322
Physical Activity in Rectal Cancer Survivors
Abramson Cancer Center at Penn Medicine
NCT06435975
Phase I Trial of Ganetespib, Capecitabine, and Radiation in Rectal Cancer
Emory University
NCT01554969
Rectal Cancer Consortium
Brown University
NCT01835925
Molecular Determinants Affecting Fluoro-L-thymidine (FLT) Positron Emission Tomography (PET) in Rectal Cancer
Vanderbilt-Ingram Cancer Center
NCT01207895
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 12 |
| Phase 2 | 19 |
| Phase 3 | 4 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Rectal Cancer Trial Landscape
ClinicalTrials.gov lists 72 US studies indexed under Rectal Cancer, and 32 of those are currently open to recruitment — roughly 44% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Rectal Cancer shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 31 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Rectal Cancer is led by Memorial Sloan Kettering Cancer Center with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 72 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Rectal Cancer?
PlainTrial tracks 72 US clinical trials for Rectal Cancer, of which 32 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Rectal Cancer?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.