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ClinicalTrials.gov 32 recruiting now official registry

Rectal Cancer clinical trials

Every US clinical trial registered for Rectal Cancer — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

72 US clinical trials · 32 currently recruiting

The research picture

Rectal Cancer has 72 registered US clinical trials, 32 of them open to new participants right now — about 44% of the total.

32
recruiting participants now
44%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
8
top sponsor: Memorial Sloan Kettering Cancer Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING 999,999 participants

Integrated Cancer Repository for Cancer Research

University of Nebraska

NCT02012699

RECRUITING 9,600 participants

Sample Collection for Ongoing Research and Product Evaluation Study

Natera

NCT07318051

RECRUITING NA 1,000 participants

Improving Nutrition and Physical Activity for Cancer Survivors (Tools To Be Fit)

University of California, San Francis

NCT05056077

RECRUITING NA 990 participants

Washington University Participant Engagement and Cancer Genomic Sequencing Center (WU-PE-CGS)

Washington University School of Medicine

NCT06340646

RECRUITING Phase 2 284 participants

A Study of Botensilimab and Balstilimab for Colorectal Cancer With ctDNA+ After Surgery and Chemotherapy

Memorial Sloan Kettering Cancer Center

NCT07227636

RECRUITING NA 257 participants

Resilience and Equity in Aging, Cancer, and Health (REACH)

Dana-Farber Cancer Institute

NCT04674267

RECRUITING Phase 3 250 participants

Neoadjuvant Chemotherapy, Excision And Observation vs Chemoradiotherapy For Rectal Cancer

Canadian Cancer Trials Group

NCT06205485

RECRUITING NA 250 participants

Efficacy and Safety of the CG-100 Intraluminal Bypass Device

Colospan

NCT04184973

RECRUITING Phase 1 240 participants

A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

A2 Biotherapeutics

NCT06682793

RECRUITING NA 200 participants

EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.

Case Comprehensive Cancer Center

NCT06263088

RECRUITING Phase 2 118 participants

Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With/Without BMX-001

University of Nebraska

NCT05254327

RECRUITING Phase 1 110 participants

Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor Recognizing the G12V Variant of Mutated RAS in HLA-A*11:01 Patients

National Cancer Institute (NCI)

NCT03190941

RECRUITING NA 90 participants

Ultrasound and Photoacoustic Imaging for Enhanced Differential Diagnosis of Rectal Cancer

Washington University School of Medicine

NCT04339374

RECRUITING NA 80 participants

An Informational and Supportive Care Intervention for Patients With Locally Advanced Rectal Cancer

Massachusetts General Hospital

NCT05914766

RECRUITING Phase 2 60 participants

A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (mCRC)

SCRI Development Innovations

NCT07011576

RECRUITING Phase 2 54 participants

Total Neoadjuvant Therapy With mFOLFOX and Short-course Radiation in Resectable Rectal Cancer

Virginia Commonwealth University

NCT04643366

RECRUITING NA 54 participants

High-Fermented Food Intervention Among Locally Advanced Rectal Cancer Patients (The FEED Trial)

H. Lee Moffitt Cancer Center and Research Institute

NCT06337552

RECRUITING 50 participants

Feasibility of Non-Operative Management of Rectal Cancer in a Rural Population

Bassett Healthcare

NCT04245683

RECRUITING Phase 2 50 participants

Sequential TAS-OX Alternating With TAS-IRI Plus Bevacizumab for Late-Line Metastatic Colorectal Cancer

Rutgers, The State University of New Jersey

NCT05806931

RECRUITING Phase 1 49 participants

Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer

Washington University School of Medicine

NCT03516708

RECRUITING Phase 2 44 participants

Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates

University of Colorado, Denver

NCT07292298

RECRUITING Phase 2 43 participants

A Phase I-II Study to Test the Safety and Efficacy of PD1 (AB122) and Adenosine Receptor (AB928) Antagonists With Chemotherapy After Short-Course Radiation for Rectal Cancer.

Weill Medical College of Cornell University

NCT05024097

RECRUITING NA 40 participants

The Impact of PReOPerative Exercise and NutritionaL Optimization on Perioperative Outcomes for Patients Undergoing Treatment for Rectal Cancer: The PROPEL Trial

Dana-Farber Cancer Institute

NCT06565052

RECRUITING Phase 2 37 participants

A Study of Tucatinib and Trastuzumab in People With Rectal Cancer

Memorial Sloan Kettering Cancer Center

NCT05672524

RECRUITING 30 participants

Exosomes in Rectal Cancer

University of Kansas Medical Center

NCT03874559

RECRUITING Phase 2 30 participants

Watchful Waiting for Complete Responders to Therapy in Rectal Cancer

Henry Ford Health System

NCT05526079

RECRUITING NA 30 participants

Evaluating a Nonessential Amino Acid Restriction (NEAAR) Medical Food With Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer (LARC)

University of South Florida

NCT06380101

RECRUITING NA 30 participants

A Study of Response to Standard Treatment Before Surgery in People With Rectal Cancer

Memorial Sloan Kettering Cancer Center

NCT06637462

RECRUITING Phase 1 27 participants

Ultra-fractionated Radiotherapy for Rectal Cancer

University of Texas Southwestern Medical Center

NCT04677413

RECRUITING NA 25 participants

The Radiation Oncology-Biology Integration Network (ROBIN) Molecular Characterization Trial (MCT) of Standard Short Course Radiotherapy for Rectal Cancer

Weill Medical College of Cornell University

NCT05943210

RECRUITING Phase 1 24 participants

F-Tryptophan PET/CT in Human Cancers

Barbara Ann Karmanos Cancer Institute

NCT05556473

RECRUITING 10 participants

Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women

Washington University School of Medicine

NCT06904365

ACTIVE NOT RECRUITING 1,275 participants

Genomic Structural Variation in Cancer Susceptibility

Memorial Sloan Kettering Cancer Center

NCT00996710

ACTIVE NOT RECRUITING Phase 3 920 participants

Rectal Cancer And Pre-operative Induction Therapy Followed by Dedicated Operation. The RAPIDO Trial

University Medical Center Groningen

NCT01558921

ACTIVE NOT RECRUITING Phase 2 358 participants

Trial Evaluating 3-year Disease Free Survival in Patients With Locally Advanced Rectal Cancer Treated With Chemoradiation Plus Induction or Consolidation Chemotherapy and Total Mesorectal Excision or Non-operative Management

Memorial Sloan Kettering Cancer Center

NCT02008656

ACTIVE NOT RECRUITING NA 300 participants

Supportive Oncology Care At Home RCT

Massachusetts General Hospital

NCT04544046

ACTIVE NOT RECRUITING 196 participants

CRC Detection Reliable Assessment With Blood

New Day Diagnostics

NCT05551052

ACTIVE NOT RECRUITING 116 participants

Relationship Between Quality of Life, Treatment Modalities, and Patient Treatment/Outcome Expectations

M.D. Anderson Cancer Center

NCT00648635

ACTIVE NOT RECRUITING NA 107 participants

RCT of Mobile Apps & FitBit v. Usual Care

Weill Medical College of Cornell University

NCT03623464

ACTIVE NOT RECRUITING NA 100 participants

Multicenter Phase II Study of Transanal TME (taTME)

Icahn School of Medicine at Mount Sinai

NCT03144765

ACTIVE NOT RECRUITING NA 60 participants

The Exercise And Colorectal Cancer Treatment Trial

Pennington Biomedical Research Center

NCT03975491

ACTIVE NOT RECRUITING Phase 2 48 participants

Study of Cabozantinib and Nivolumab in Refractory Metastatic Microsatellite Stable (MSS) Colorectal Cancer

University of Colorado, Denver

NCT04963283

ACTIVE NOT RECRUITING NA 40 participants

Microbiome and Rectal Cancer

University of South Florida

NCT04223102

ACTIVE NOT RECRUITING 39 participants

Transanal Total Mesorectal Excision for Rectal Cancer on Anal Physiology + Fecal Incontinence

Case Comprehensive Cancer Center

NCT03283540

ACTIVE NOT RECRUITING NA 20 participants

Copper Cu 64 Anti-CEA Monoclonal Antibody M5A PET in Diagnosing Patients With CEA Positive Cancer

City of Hope Medical Center

NCT02293954

ACTIVE NOT RECRUITING Phase 1 20 participants

Early Phase Clinical Trial About Therapeutic Biological Product Mix for Treating CEA Positive Rectal Cancer

Han Xu, M.D., Ph.D., FAPCR, Sponsor-Investigator, IRB Chair

NCT02403505

ACTIVE NOT RECRUITING Phase 2 19 participants

Organ Preservation in Early Rectal Cancer Patients

Fox Chase Cancer Center

NCT03548961

ACTIVE NOT RECRUITING Phase 1 14 participants

A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Effectiveness of GSK4418959 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors

GlaxoSmithKline

NCT06710847

COMPLETED 200,000 participants

General Surgical Outcomes Quality Improvement Database (UH-SOCRATES)

University Hospitals Cleveland Medical Center

NCT00622557

COMPLETED NA 1,900 participants

Adherence to Colon Cancer Screening (ACCS)

Ohio State University Comprehensive Cancer Center

NCT02112747

COMPLETED NA 375 participants

Negative Pressure Therapy in Preventing Infection After Surgery in Patients With Colon, Rectal, Pancreatic, or Peritoneal Surface Cancer

Wake Forest University Health Sciences

NCT01656044

COMPLETED NA 284 participants

Patient Activation Intervention in Improving Screening Rates for Colorectal Cancer

Ohio State University Comprehensive Cancer Center

NCT01801059

COMPLETED Phase 1 229 participants

A Study of LY2880070 in Participants With Advanced or Metastatic Cancer

Esperas Pharma

NCT02632448

COMPLETED Phase 1 202 participants

Phase 1b/2 Study of AMG 655 With mFOLFOX6 and Bevacizumab for First-Line Metastatic Colorectal Cancer

Amgen

NCT00625651

COMPLETED 192 participants

The Sexual Health of Rectal Cancer Patients

Memorial Sloan Kettering Cancer Center

NCT00712751

COMPLETED 115 participants

GI SPORE Colon Biosample Protocol

University of Michigan

NCT02243267

COMPLETED NA 84 participants

Evaluating The Response to Pre-Operative Chemotherapy and/or Radiation Therapy For Rectal Cancer Using Three-Dimension Transrectal Ultrasound

Memorial Sloan Kettering Cancer Center

NCT00597610

COMPLETED Phase 3 69 participants

An Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy

Corewell Health West

NCT00467922

COMPLETED Phase 2 66 participants

5-Fluorouracil, Bevacizumab, and Radiation Followed by Modified FOLFOX6 and Bevacizumab in Stage II/III Rectal Cancer

SCRI Development Innovations

NCT00308516

COMPLETED 59 participants

Computer-Based Comprehensive Geriatric Assessment in Oncology for Individuals 70 or Older With Gastrointestinal Malignancies

Dana-Farber Cancer Institute

NCT00973440

COMPLETED Phase 1 50 participants

CB-839 + Capecitabine in Solid Tumors and Fluoropyrimidine Resistant PIK3CA Mutant Colorectal Cancer

David Bajor, MD

NCT02861300

COMPLETED Phase 2 48 participants

Clinical Trial in Patients With Metastatic Colorectal Cancer

Mast Therapeutics

NCT00081627

COMPLETED Phase 3 46 participants

Promoting Physical Activity After Colorectal Cancer

The Miriam Hospital

NCT00230646

COMPLETED Phase 2 39 participants

5-FU, Aflibercept, and Radiation (RT) for Preoperative and Postoperative Patients With Stage II/III Rectal Cancer

SCRI Development Innovations

NCT01749956

COMPLETED Phase 2 25 participants

Neoadjuvant Chemoradiation With RHUMAB VEGF (Avastin) for Rectal Cancer

M.D. Anderson Cancer Center

NCT00113230

COMPLETED Phase 2 20 participants

Non-Operative Radiation Management of Adenocarcinoma of the Lower Rectum

Washington University School of Medicine

NCT02641691

COMPLETED Phase 2 20 participants

Clinical and Translational Study of STA-9090

Memorial Sloan Kettering Cancer Center

NCT01111838

COMPLETED Phase 2 20 participants

Cellular Immune Augmentation in Colon and Rectal Cancer

University of California, Irvine

NCT00257322

COMPLETED NA 20 participants

Physical Activity in Rectal Cancer Survivors

Abramson Cancer Center at Penn Medicine

NCT06435975

COMPLETED Phase 1 16 participants

Phase I Trial of Ganetespib, Capecitabine, and Radiation in Rectal Cancer

Emory University

NCT01554969

COMPLETED 12 participants

Rectal Cancer Consortium

Brown University

NCT01835925

COMPLETED Phase 1 5 participants

Molecular Determinants Affecting Fluoro-L-thymidine (FLT) Positron Emission Tomography (PET) in Rectal Cancer

Vanderbilt-Ingram Cancer Center

NCT01207895

Phase Distribution

PhaseTrial count
Phase 1 12
Phase 2 19
Phase 3 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Rectal Cancer Trial Landscape

ClinicalTrials.gov lists 72 US studies indexed under Rectal Cancer, and 32 of those are currently open to recruitment — roughly 44% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Rectal Cancer shows 4 late-stage studies (Phase 3 and Phase 4 combined) alongside 31 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Rectal Cancer is led by Memorial Sloan Kettering Cancer Center with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 72 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Rectal Cancer?

PlainTrial tracks 72 US clinical trials for Rectal Cancer, of which 32 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Rectal Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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