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ClinicalTrials.gov 32 recruiting now official registry

Rectal Cancer clinical trials

32 of 72 indexed Rectal Cancer trials are currently recruiting.

72 US clinical trials · 32 currently recruiting

Rectal Cancer is the subject of 72 registered US clinical trials on ClinicalTrials.gov, 32 of them currently open to new participants. 4 are in Phase 3-4 (later-stage) and 31 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 8 of these trials.

The research picture

Rectal Cancer has 72 registered US clinical trials, 32 of them open to new participants right now, about 44% of the total.

32
recruiting participants now
44%
of trials open to enrollment
4
in Phase 3–4 (later-stage)
8
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 112Phase 219Phase 34

Active & Recent Trials

72 total, page 2 of 2

COMPLETED NA 375 participants

Negative Pressure Therapy in Preventing Infection After Surgery in Patients With Colon, Rectal, Pancreatic, or Peritoneal Surface Cancer

Wake Forest University Health Sciences

NCT01656044

COMPLETED NA 284 participants

Patient Activation Intervention in Improving Screening Rates for Colorectal Cancer

Ohio State University Comprehensive Cancer Center

NCT01801059

COMPLETED Phase 1 229 participants

A Study of LY2880070 in Participants With Advanced or Metastatic Cancer

Esperas Pharma

NCT02632448

COMPLETED Phase 1 202 participants

Phase 1b/2 Study of AMG 655 With mFOLFOX6 and Bevacizumab for First-Line Metastatic Colorectal Cancer

Amgen

NCT00625651

COMPLETED 192 participants

The Sexual Health of Rectal Cancer Patients

Memorial Sloan Kettering Cancer Center

NCT00712751

COMPLETED 115 participants

GI SPORE Colon Biosample Protocol

University of Michigan

NCT02243267

COMPLETED NA 84 participants

Evaluating The Response to Pre-Operative Chemotherapy and/or Radiation Therapy For Rectal Cancer Using Three-Dimension Transrectal Ultrasound

Memorial Sloan Kettering Cancer Center

NCT00597610

COMPLETED Phase 3 69 participants

An Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy

Corewell Health West

NCT00467922

COMPLETED Phase 2 66 participants

5-Fluorouracil, Bevacizumab, and Radiation Followed by Modified FOLFOX6 and Bevacizumab in Stage II/III Rectal Cancer

SCRI Development Innovations

NCT00308516

COMPLETED 59 participants

Computer-Based Comprehensive Geriatric Assessment in Oncology for Individuals 70 or Older With Gastrointestinal Malignancies

Dana-Farber Cancer Institute

NCT00973440

COMPLETED Phase 1 50 participants

CB-839 + Capecitabine in Solid Tumors and Fluoropyrimidine Resistant PIK3CA Mutant Colorectal Cancer

David Bajor, MD

NCT02861300

COMPLETED Phase 2 48 participants

Clinical Trial in Patients With Metastatic Colorectal Cancer

Mast Therapeutics

NCT00081627

COMPLETED Phase 3 46 participants

Promoting Physical Activity After Colorectal Cancer

The Miriam Hospital

NCT00230646

COMPLETED Phase 2 39 participants

5-FU, Aflibercept, and Radiation (RT) for Preoperative and Postoperative Patients With Stage II/III Rectal Cancer

SCRI Development Innovations

NCT01749956

COMPLETED Phase 2 25 participants

Neoadjuvant Chemoradiation With RHUMAB VEGF (Avastin) for Rectal Cancer

M.D. Anderson Cancer Center

NCT00113230

COMPLETED Phase 2 20 participants

Non-Operative Radiation Management of Adenocarcinoma of the Lower Rectum

Washington University School of Medicine

NCT02641691

COMPLETED Phase 2 20 participants

Clinical and Translational Study of STA-9090

Memorial Sloan Kettering Cancer Center

NCT01111838

COMPLETED Phase 2 20 participants

Cellular Immune Augmentation in Colon and Rectal Cancer

University of California, Irvine

NCT00257322

COMPLETED NA 20 participants

Physical Activity in Rectal Cancer Survivors

Abramson Cancer Center at Penn Medicine

NCT06435975

COMPLETED Phase 1 16 participants

Phase I Trial of Ganetespib, Capecitabine, and Radiation in Rectal Cancer

Emory University

NCT01554969

COMPLETED 12 participants

Rectal Cancer Consortium

Brown University

NCT01835925

COMPLETED Phase 1 5 participants

Molecular Determinants Affecting Fluoro-L-thymidine (FLT) Positron Emission Tomography (PET) in Rectal Cancer

Vanderbilt-Ingram Cancer Center

NCT01207895

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Phase Distribution

PhaseTrial count
Phase 1 12
Phase 2 19
Phase 3 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Rectal Cancer Trial Landscape

72 indexed Rectal Cancer studies · 32 recruiting (44%).

Phase mix: 4 late (III/IV) vs 31 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (8 trials), 9 others listed. 22 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Rectal Cancer?

PlainTrial tracks 72 US clinical trials for Rectal Cancer, of which 32 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Rectal Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.