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ClinicalTrials.gov 14 recruiting now official registry

Preterm Birth clinical trials

14 of 38 indexed Preterm Birth trials are currently recruiting.

38 US clinical trials · 14 currently recruiting

Preterm Birth is the subject of 38 registered US clinical trials on ClinicalTrials.gov, 14 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 4 in Phase 1-2 (earlier-stage). The most active sponsor is Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), running 3 of these trials.

The research picture

Preterm Birth has 38 registered US clinical trials, 14 of them open to new participants right now, about 37% of the total.

14
recruiting participants now
37%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
3
top sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Phase 11Phase 23Phase 42

Active & Recent Trials

38 total, page 1 of 1

RECRUITING NA 550 participants

Optimal Timing of Routine Cervical Length Measurements During Anatomy Survey

Henry Ford Health System

NCT06822647

RECRUITING NA 420 participants

Effect of Support for Low-Income Mothers of Preterm Infants

University of Massachusetts, Worcester

NCT06362798

RECRUITING Phase 1 400 participants

Daily Aspirin vs Split Dosing in High-risk Pregnancies (DASH)

Thomas Jefferson University

NCT06826859

RECRUITING 240 participants

Prospective Evaluation of Pathways for Preterm Birth

John O'Brien, MD

NCT05246579

RECRUITING NA 238 participants

Reducing Pregnancy Risks: The Mastery Lifestyle Intervention

Microgen

NCT05012072

RECRUITING NA 180 participants

Stress Phenotypes and Preterm Birth

Columbia University

NCT05229666

RECRUITING NA 140 participants

Blood Warming in Preterm Infants to Decrease Hypothermia

University of South Carolina

NCT05170633

RECRUITING NA 60 participants

Mitochondrial DNA Signatures of Poor Aerobic Exercise Trainability in Young Adults Born Preterm

Texas Tech University

NCT06334107

RECRUITING Phase 4 56 participants

Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)

Ohio State University

NCT06396078

RECRUITING Phase 2 50 participants

The Effect of Sulfasalazine on CRH Levels in Pregnant Women

Rutgers, The State University of New Jersey

NCT05703425

RECRUITING NA 40 participants

Bilateral Infant Stimulation Study

Oregon Health and Science University

NCT06353243

RECRUITING NA 40 participants

Sodium Awareness in Lactation Trial

The Hospital for Sick Children

NCT06563726

RECRUITING Phase 4 34 participants

Latency Antibiotics in Previable PPROM, 18 0/7- 22 6/7 WGA

Woman's

NCT04047849

RECRUITING NA 20 participants

Transition From Donor Milk: a Feasibility Study

Augusta University

NCT06514014

ACTIVE NOT RECRUITING 10,000 participants

MIRACLE of LIFE Study

Mirvie

NCT06074601

ACTIVE NOT RECRUITING NA 6,500 participants

Prematurity Risk Assessment Combined With Clinical Interventions for Improving Neonatal outcoMEs

Sera Prognostics

NCT04301518

ACTIVE NOT RECRUITING NA 5,670 participants

Nurse-Family Partnership Impact Evaluation in South Carolina

Harvard School of Public Health (HSPH)

NCT03360539

ACTIVE NOT RECRUITING NA 906 participants

Positive End-Expiratory Pressure (PEEP) Levels During Resuscitation of Preterm Infants at Birth (The POLAR Trial).

Murdoch Childrens Research Institute

NCT04372953

ACTIVE NOT RECRUITING NA 190 participants

Promoting Kangaroo Care for Preterm or Low Birthweight Infants in Rural India

University of Massachusetts, Worcester

NCT07231432

ACTIVE NOT RECRUITING NA 130 participants

Targeting Human Milk Fortification to Improve Preterm Infant Growth and Brain Development

Brigham and Women's Hospital

NCT03977259

ACTIVE NOT RECRUITING Phase 2 120 participants

Glycemic Control After Antenatal Corticosteroids in Women With Pregestational and Gestational Diabetes

University of Alabama at Birmingham

NCT04542148

COMPLETED 89,132 participants

Comparative Effectiveness of Treatment Options for Genital Herpes Infection to Reduce Adverse Pregnancy Outcomes

Kaiser Permanente

NCT02986802

COMPLETED 30,570 participants

Establishment of a Perinatal Database and a Bank of Biological Materials

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT00339235

COMPLETED 12,344 participants

Assessing the Effectiveness and Efficacy of the MyHealthyPregnancy Application

Naima Health

NCT05502510

COMPLETED 5,011 participants

A Multicenter Assessment of a Spontaneous Preterm Birth Risk Predictor

Sera Prognostics

NCT02787213

COMPLETED 4,673 participants

Clinical, Biochemical, Histological and Biophysical Parameters in the Prediction of Cerebral Palsy in Patients With Preterm Labor and Premature Rupture of Membranes

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT00342667

COMPLETED NA 1,637 participants

The Australian Placental Transfusion Study (APTS): Should Very Pre Term Babies Receive a Placental Blood Transfusion at Birth Via Deferring Cord Clamping Versus Standard Cord Clamping Procedures?

University of Sydney

NCT02606058

COMPLETED 648 participants

Cervical Volume by Three-Dimensional Ultrasound as a Predictor of Preterm Delivery

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NCT00342550

COMPLETED Phase 2 482 participants

Reducing Preterm Births in Underserved Pregnant Women

PHCC

NCT01344616

COMPLETED NA 236 participants

Tennessee Connections for Better Birth Outcomes

Vanderbilt University

NCT00502697

COMPLETED NA 221 participants

Mobile Strategy to Reduce the Risk of Recurrent Preterm Birth

Stanford University

NCT04663607

COMPLETED 89 participants

The Impact of Vaginal and IM Progestins on the Cervix

University of Pittsburgh

NCT01954095

COMPLETED NA 80 participants

Enhanced Nutrition for Preterm Infants

University of Minnesota

NCT03238768

COMPLETED 79 participants

Biomarkers of Intra-amniotic Infection in Women With Preterm Premature Ruptured Amniotic Membranes

ProteoGenix

NCT00701350

COMPLETED NA 68 participants

Supporting Mothers of Preterm Infants

Tufts Medical Center

NCT03013660

COMPLETED 40 participants

Impact of Currently Recommended Postnatal Nutrition on Neonatal Body Composition

Vishal Pandey, M.D.

NCT02622373

COMPLETED NA 8 participants

Pilot Study to Evaluate a Prototype Electronic Uterine Inhibitor to Prevent Preterm Contractions

St. Luke's-Roosevelt Hospital Center

NCT00212446

COMPLETED 3 participants

Protein and Ultrasound Indicators of Preterm Birth

University of Colorado, Denver

NCT01412931

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 3
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Preterm Birth Trial Landscape

38 indexed Preterm Birth studies · 14 recruiting (37%).

Phase mix: 2 late (III/IV) vs 4 early (I/II).

Top sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (3 trials), 9 others listed. 38 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Preterm Birth?

PlainTrial tracks 38 US clinical trials for Preterm Birth, of which 14 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Preterm Birth?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.