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NCT05246579 · ClinicalTrials.gov registry record
Prospective Evaluation of Pathways for Preterm Birth
A clinical trial of Preterm Birth and Cervix; Pregnancy, sponsored by John O'Brien, MD.
- Recruiting
- Registry status
- 240
- Enrollment target
- 1
- Study location
NCT05246579: Recruiting study of Preterm Birth and Cervix; Pregnancy, sponsored by John O'Brien, MD.
NCT05246579 is a study of Preterm Birth and Cervix; Pregnancy that is actively recruiting participants, run by John O'Brien, MD. The registered enrollment target is 240 participants, below the 4,403-participant average among 39 other Preterm Birth trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05246579, a study of Preterm Birth and Cervix; Pregnancy, is actively recruiting participants, sponsored by John O'Brien, MD.
- RECRUITING
- Registry status
- 240 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a single center, prospective cohort study of pregnant patients at high risk for spontaneous preterm birth: patient's with history of spontaneous preterm birth, patient's with a short cervix and patient's symptomatic for preterm birth will be included. A control cohort of nulliparous patients without a short cervix will be recruited to provide baseline data. Plan to enroll 240 patients identified through our ultrasound unit with goal of 60 patients in each group.
Primary Outcome
Serum and Cervicovaginal cytokine profile (CRP, ICAM-1, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-8 (HA), IL-10, MCP-1, PIGF, TNFα, TNFβ)
Conditions Studied
Study Locations (1)
Kentucky
- University of Kentucky - Lexington
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 240 participants |
| Start Date | 2022-02-04 |
| Est. Completion | 2026-06-01 |
What NCT05246579 shows while recruiting
NCT05246579 is an observational study that tracks outcomes without assigning an intervention. The registered 240 participants enrollment target is mid-sized for trials with a published cap, below the 4,403-participant average among 39 other Preterm Birth trials with a reported enrollment target (95% lower).
The record links to 2 conditions, with Preterm Birth appearing as the primary indexed condition, and to 0 interventions.
NCT05246579 reports a single indexed study location in Kentucky.
Frequently Asked Questions
What is clinical trial NCT05246579 about?
NCT05246579 is a clinical study titled "Prospective Evaluation of Pathways for Preterm Birth". This is a single center, prospective cohort study of pregnant patients at high risk for spontaneous preterm birth: patient's with history of spontaneous preterm birth, patient's with a short cervix and patient's symptomatic for preterm birth will be included. A control cohort of nulliparous patients...
What is the current status of trial NCT05246579?
This trial is currently recruiting. The enrollment target is 240 participants. The study started on 2022-02-04. Estimated completion is 2026-06-01.
What conditions does trial NCT05246579 study?
This clinical trial studies the following conditions: Preterm Birth, Cervix; Pregnancy.
Who is sponsoring clinical trial NCT05246579?
This trial is sponsored by John O'Brien, MD, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05246579 being conducted?
This trial has 1 study location across Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Preterm Birth
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05246579's enrollment target sits among peer trials
240 17th of 39 higher than 23 of 39 other Preterm Birth trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Preterm Birth trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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