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NCT06334107 · ClinicalTrials.gov registry record · NA
Mitochondrial DNA Signatures of Poor Aerobic Exercise Trainability in Young Adults Born Preterm
A NA study of Preterm Birth, sponsored by Texas Tech University.
- Recruiting
- Registry status
- NA
- Development phase
- 60
- Enrollment target
- 1
- Study location
NCT06334107 is a NA study of Preterm Birth that is actively recruiting participants, run by Texas Tech University. The registered enrollment target is 60 participants, below the 4,628-participant average among 37 other Preterm Birth trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state.
The verdict
NCT06334107, a NA study of Preterm Birth, is actively recruiting participants, sponsored by Texas Tech University.
- RECRUITING
- Registry status
- NA
- Development phase
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
Young adults born very preterm (32 weeks gestation or earlier) do not respond well to aerobic exercise training, meeting the recommendations set by the Physical Activity Guidelines for Americans, where they do not increase their fitness level (or cardiorespiratory fitness). Thus, they do not receive the health benefits of exercise. Achieving physical fitness through aerobic exercise training is the most cost-effective method for preventing and treating many diseases. Young adults born very preterm also have a higher risk of these conditions. Thus, their inability to respond to increase their fitness is a major problem. One likely explanation for poor exercise trainability and increased heart disease risk in young adults born very preterm is the effect of the early birth on the major energy producers in all our cells: Mitochondria. During late-stage gestation, mitochondria change from relying on sugar as a major fuel source to fat. Unfortunately, individuals born very preterm miss this transition in fuel source reliance, which causes significant stress and damage to mitochondria. Mitochondria are critical for post-natal organ development; thus, it is thought that preterm birth-induced mitochondrial dysfunction is the underlying cause of poor trainability and high disease risk in young adults born very preterm. Indeed, mitochondrial dysfunction is evident in these individuals. To date, there is not a way to help young adults born preterm improve their fitness level. One likely target is in the mitochondria: it's DNA. Mitochondrial DNA helps determine how mitochondria function and can be damaged under stress. Our goal in this proposed work is to determine the role of mitochondrial DNA in mitochondrial dysfunction and its link to their poor trainability. Questions: 1. Are there mitochondrial DNA markers linked to mitochondrial dysfunction and poor exercise trainability in young adults very born preterm? 2. Do mitochondrial DNA in young adults born very preterm respo
Conditions Studied
Interventions
- BEHAVIORAL Exercise
Study Locations (1)
Texas
- Texas Tech University | Kinesiology and Sport Management Building - Lubbock
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2024-05-01 |
| Est. Completion | 2026-12-31 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06334107
The ClinicalTrials.gov registry entry for NCT06334107 describes a study currently listed as recruiting, categorized as NA. The registered enrollment target is 60 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 4,628-participant average among 37 other Preterm Birth trials with a reported enrollment target (99% lower). The listed sponsor is Texas Tech University, which has 69 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Preterm Birth appearing as the primary indexed condition, and to 1 intervention - of which Exercise is the first listed.
NCT06334107 reports 1 study location spanning 1 distinct geographic area - top geographies include Texas.
Frequently Asked Questions
What is clinical trial NCT06334107 about?
NCT06334107 is a clinical study titled "Mitochondrial DNA Signatures of Poor Aerobic Exercise Trainability in Young Adults Born Preterm". Young adults born very preterm (32 weeks gestation or earlier) do not respond well to aerobic exercise training, meeting the recommendations set by the Physical Activity Guidelines for Americans, where they do not increase their fitness level (or cardiorespiratory fitness). Thus, they do not receive...
What is the current status of trial NCT06334107?
This trial is currently recruiting. It is a NA study. The enrollment target is 60 participants. The study started on 2024-05-01. Estimated completion is 2026-12-31.
What conditions does trial NCT06334107 study?
This clinical trial studies the following conditions: Preterm Birth.
What interventions are being tested in trial NCT06334107?
The interventions under investigation include: Exercise (BEHAVIORAL).
Who is sponsoring clinical trial NCT06334107?
This trial is sponsored by Texas Tech University, which has 69 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06334107 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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