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Study of Urate Elevation in Parkinson's Disease, Phase 3
NCT02642393 · View on ClinicalTrials.gov ↗
Study Summary
A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial to determine whether oral inosine dosed to moderately elevate serum urate (from ≤5.7 mg/dL to 7.1-8.0 mg/dL) over 2 years slows clinical decline in early PD. Clinical decline will be assessed as change in the primary outcome variable of the Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), a composite scale comprising patient- and clinician-reported outcomes.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Inosine
Study Locations (20)
California
- University of California San Diego — La Jolla
- University of Southern California — Los Angeles
- University of California Davis — Sacramento
- University of California San Francisco — San Francisco
Arizona
- Barrow Neurological Institute — Phoenix
- Mayo Clinic Arizona — Scottsdale
- Banner Sun Health Research Institute — Sun City
Illinois
- Northwestern University — Chicago
- Rush University Medical Center — Chicago
- Neurosciences Institute at Central DuPage Hospital — Winfield
Colorado
- University of Colorado — Aurora
- Rocky Mountain Movement Disorder Center — Englewood
Georgia
- Emory University — Atlanta
- Augusta University — Augusta
Alabama
- University of Alabama at Birmingham — Birmingham
Connecticut
- Hartford HealthCare Movement Disorders Center — Vernon
Florida
- University of South Florida — Tampa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 298 participants |
| Start Date | 2016-06 |
| Est. Completion | 2019-06 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02642393
The ClinicalTrials.gov registry entry for NCT02642393 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 298 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Michael Alan Schwarzschild, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Parkinson's Disease appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT02642393 reports 20 study locations spanning 11 distinct geographic areas — top geographies include California, Arizona, Illinois. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT02642393 about?
NCT02642393 is a clinical study titled "Study of Urate Elevation in Parkinson's Disease, Phase 3". A multicenter, randomized, double-blind, placebo-controlled, phase 3 trial to determine whether oral inosine dosed to moderately elevate serum urate (from ≤5.7 mg/dL to 7.1-8.0 mg/dL) over 2 years slows clinical decline in early PD. Clinical decline will be assessed as change in the primary outcome...
What is the current status of trial NCT02642393?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 298 participants. The study started on 2016-06. Estimated completion is 2019-06.
What conditions does trial NCT02642393 study?
This clinical trial studies the following conditions: Parkinson's Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT02642393?
The interventions under investigation include: Placebo (DRUG), Inosine (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT02642393?
This trial is sponsored by Michael Alan Schwarzschild, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT02642393 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Colorado, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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