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A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)
NCT06864026 · View on ClinicalTrials.gov ↗
Study Summary
The main purpose of this study is to assess the effectiveness of adding tirzepatide to ixekizumab therapy in standard clinical practice in participants with moderate-to-severe PsA and obesity or overweight with at least 1 weight-related comorbidity. The study will last up to 12 months.
Conditions Studied
Interventions
- DRUG Tirzepatide
Study Locations (20)
Arizona
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Avondale — Avondale
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Chandler — Chandler
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Flagstaff — Flagstaff
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Gilbert — Gilbert
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Glendale — Glendale
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Mesa — Mesa
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Phoenix PV — Phoenix
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Sun City — Sun City
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Tucson — Tucson
- AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Tucson Southeast — Tucson
California
- Medvin Clinical Research - Apple Valley — Apple Valley
- Medvin Clinical Research - Covina — Covina
- Newport Huntington Medical Group — Huntington Beach
- Purushotham & Akther Kotha MD, Inc — La Mesa
- Medvin Clinical Research - Riverside — Riverside
- Rheumatology Center of San Diego — San Diego
- Providence Saint John's Medical Foundation — Santa Monica
- Medvin Clinical Research - Temecula — Temecula
- Medvin Clinical Research - Tujunga — Tujunga
- Medvin Clinical Research - Whittier — Whittier
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2025-03-06 |
| Est. Completion | 2027-11 |
| Phase | Phase 4 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06864026
The ClinicalTrials.gov registry entry for NCT06864026 describes a study currently listed as recruiting. It is categorized as Phase 4, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Psoriatic Arthritis appearing as the primary indexed condition, and to 1 intervention — of which Tirzepatide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06864026 reports 20 study locations spanning 2 distinct geographic areas — top geographies include Arizona, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06864026 about?
NCT06864026 is a clinical study titled "A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)". The main purpose of this study is to assess the effectiveness of adding tirzepatide to ixekizumab therapy in standard clinical practice in participants with moderate-to-severe PsA and obesity or overweight with at least 1 weight-related comorbidity. The study will last up to 12 months.
What is the current status of trial NCT06864026?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 200 participants. The study started on 2025-03-06. Estimated completion is 2027-11.
What conditions does trial NCT06864026 study?
This clinical trial studies the following conditions: Psoriatic Arthritis, Overweight or Obesity. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06864026?
The interventions under investigation include: Tirzepatide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06864026?
This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06864026 being conducted?
This trial has 20 study locations across Arizona, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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