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RECRUITING Phase 3

A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1

NCT06948435 · View on ClinicalTrials.gov ↗

Study Summary

GZL1 is an independent study conducted under the GZPL master protocol. GZL1 will evaluate the efficacy and safety of orforglipron for treatment of hypertension in participants with obesity or overweight.

Interventions

  • DRUG Placebo
  • DRUG Orforglipron

Study Locations (20)

Florida

  • Excel Medical Clinical Trials — Boca Raton
  • Care Access - Brandon — Brandon
  • Northeast Research Institute - Downtown Office — Jacksonville
  • Peace River Cardiovascular Center — Port Charlotte

California

  • Valley Clinical Trials, Inc. — Covina
  • Valley Clinical Trials, Inc. — Northridge

Nevada

  • Excel Clinical Research, LLC — Las Vegas
  • Palm Research Center Sunset — Las Vegas

Ohio

  • Remington-Davis, Inc — Columbus
  • PriMED Clinical Research — Dayton

Arizona

  • Elite Clinical Studies, LLC — Phoenix

Connecticut

  • Chase Medical Research, LLC — Waterbury

Hawaii

  • East-West Medical Research Institute — Honolulu

Maryland

  • Ascension Saint Agnes Heart Care — Baltimore

Trial Details

FieldValue
Enrollment Target 487 participants
Start Date 2025-04-30
Est. Completion 2027-09
Phase Phase 3

Sponsor

Eli Lilly and Company

704 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06948435

The ClinicalTrials.gov registry entry for NCT06948435 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 487 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Eli Lilly and Company, which has 704 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Hypertension appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06948435 reports 20 study locations spanning 14 distinct geographic areas — top geographies include Florida, California, Nevada. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06948435 about?

NCT06948435 is a clinical study titled "A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1". GZL1 is an independent study conducted under the GZPL master protocol. GZL1 will evaluate the efficacy and safety of orforglipron for treatment of hypertension in participants with obesity or overweight.

What is the current status of trial NCT06948435?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 487 participants. The study started on 2025-04-30. Estimated completion is 2027-09.

What conditions does trial NCT06948435 study?

This clinical trial studies the following conditions: Hypertension, Overweight or Obesity. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06948435?

The interventions under investigation include: Placebo (DRUG), Orforglipron (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06948435?

This trial is sponsored by Eli Lilly and Company, which has 704 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06948435 being conducted?

This trial has 20 study locations across Arizona, California, Connecticut, Florida, Hawaii. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial