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Overweight and Obesity clinical trials
40 of 116 indexed Overweight and Obesity trials are currently recruiting.
116 US clinical trials · 40 currently recruiting
Overweight and Obesity is the subject of 116 registered US clinical trials on ClinicalTrials.gov, 40 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 8 of these trials.
The research picture
Overweight and Obesity has 116 registered US clinical trials, 40 of them open to new participants right now, about 34% of the total.
- 40
- recruiting participants now
- 34%
- of trials open to enrollment
- 2
- in Phase 3–4 (later-stage)
- 8
- top sponsor: University of Colorado, Denver
Active & Recent Trials
116 total, page 2 of 3
Daily Caloric Restriction in ADPKD
University of Colorado, Denver
NCT04907799
An Open Label 100 Person Study Evaluating a Natural Supplement for Weight Loss and Fat Loss.
Prostasis, LLC, dba Tonum Health
NCT07152470
Fitbit Device Use in Overweight Pregnancy
University of Arizona
NCT06226597
Training Effects on Fuel Metabolism
University of Minnesota
NCT02150889
Targeting Weight and Shape Concern Among Women with High Body Weight
The Miriam Hospital
NCT05845866
Use of Empagliflozin to Treat Prediabetes
Oregon State University
NCT05426525
TREAT to Improve Cardiometabolic Health
Columbia University
NCT04465721
Fasting ENHANCE Pilot Study
University of Florida
NCT05732935
Telehealth Weight Loss Program for Breast Cancer Survivors
Abramson Cancer Center at Penn Medicine
NCT04855552
Developing a Weight Management Class as a Recruitment Tool for an Online Weight Loss Program to Rural Illinois Residents
University of Illinois at Urbana-Champaign
NCT06406985
Time and Nutrient-Dependent Effects of Aerobic Exercise on Metabolism in Adults (TANDEM Study)
University of Colorado, Denver
NCT06311487
Postprandial Inflammation and Nuts (PIN) in Older Adults
Rutgers, The State University of New Jersey
NCT06348771
Dietary Oils to Sustain Energy Study
Ohio State University
NCT04975763
Improving Metabolic & Mental Health in Female Healthcare Shift Workers
Auburn University
NCT06158204
Evaluating the Influence of Diet-induced Weight Loss on Fat (Adipose) Tissue's Insulin Sensitivity and Testosterone Synthesis in Women With Overweight or Obesity, Insulin Resistance, and Hyperandrogenemia
University of Missouri-Columbia
NCT06998238
SWITCH Implementation Effectiveness Trial
Iowa State University
NCT04045288
Evaluation of the BOKS Before-school Physical Activity Program
Massachusetts General Hospital
NCT03190135
NOURISH+: Nourishing Our Understanding of Role Modeling to Improve Support and Health
Virginia Commonwealth University
NCT01361243
Train Your Brain - Executive Function
USDA Grand Forks Human Nutrition Research Center
NCT05938894
Healthy Mothers-Healthy Children Nutrition
University of Miami
NCT03866902
Promoting Lifestyle Change Via Tailored mHealth Feedback to Improve Health
University of Pittsburgh
NCT03367936
Fit and Strong! Plus Comparative Effectiveness Trial
University of Illinois at Chicago
NCT03180008
Daily Self-Weighing for Obesity Management in Primary Care
University of Alabama at Birmingham
NCT04044794
Randomized Trial Of Achieving Healthy Lifestyles In Psych Rehabilitation
Johns Hopkins University
NCT00902694
Tailored Lifestyle Intervention in Obese Adults Within Primary Care Practice - Choose to Lose
Memorial Hospital of Rhode Island
NCT01542671
Healthy Summer Learners
University of South Carolina
NCT03321071
A Study of LY3305677 Compared With Placebo in Adult Participants With Obesity or Overweight
Eli Lilly and Company
NCT06124807
Madres Para la Salud (Mothers for Health)
Arizona State University
NCT01908959
Nonalcoholic Fatty Liver Disease and Atherosclerotic Risk in Children
Augusta University
NCT02383485
Strong People Strength Training Study
Cornell University
NCT04203563
Heart Health 4 New Moms: A Randomized Trial in the First Year After Preeclampsia
University of Pittsburgh
NCT03749746
Circadian Timing, Information Processing and Energy Balance Study
University of Utah
NCT04759755
Healthy Eating, Activity and Reduction of Teen Stress
Kent State University
NCT04038684
Behavioral Treatment for Weight Loss
Drexel University
NCT00746265
IgG-mediated Food Test for Weight Loss
University of Miami
NCT01592071
A Study to Evaluate the Safety and Efficacy of NG101 in Adult Participants Receiving a Glucagon-like Peptide-1 (GLP-1) Agonist
Neurogastrx
NCT06500429
Healthy Body Healthy Souls in the Marshallese Population
University of Arkansas
NCT03377244
UCSD Get Fit, Be Fit Study
University of California, San Diego
NCT03387709
PATH to Health: An Exploration of Digital Behavioral Weight Loss Approaches
University of North Carolina, Chapel Hill
NCT05929469
Pilot Study on the Effects of a Plant-Strong Diet on Cardiovascular Risk Factors
Phoenix VA Health Care System
NCT03330548
Dairy Foods and Weight Loss
USDA, Western Human Nutrition Research Center
NCT00858312
Safety and Efficacy of the SMART Device for Overweight and Obese Adults
Scientific Intake Limited
NCT02119299
Evaluation of a Lifestyle Medicine Practice
Ohio University
NCT03739034
A Trial to Assess Steviol Glycosides on Acute Appetite Hormone Release
Midwest Center for Metabolic and Cardiovascular Research
NCT05287906
ACT1ON Phase 2 (SMART Pilot) and Phase 3 (Efficacy Trial Development)
University of North Carolina, Chapel Hill
NCT03651622
Novel Executive Function Training for Obesity
University of California, San Diego
NCT03724396
Microalgae Extract Phaeosol Combined to Exercise in Healthy Overweight Women : Efficacy on Body Weight Management
Microphyt
NCT04761406
Optimizing Weight Loss Outcomes Through Body Image Enhancement
Texas Tech University
NCT05090293
Cognitive Behavioral Therapy for Adolescent Binge Eating and Loss of Control Eating
Yale University
NCT04088097
Improving Emotion Regulation Skills Among Adolescents Attempting to Lose Weight
Rhode Island Hospital
NCT03393221
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 4 |
| Phase 2 | 8 |
| Phase 3 | 1 |
| Phase 4 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Overweight and Obesity Trial Landscape
116 indexed Overweight and Obesity studies · 40 recruiting (34%).
Phase mix: 2 late (III/IV) vs 12 early (I/II).
Top sponsor: University of Colorado, Denver (8 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Overweight and Obesity?
PlainTrial tracks 116 US clinical trials for Overweight and Obesity, of which 40 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Overweight and Obesity?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.