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ClinicalTrials.gov 40 recruiting now official registry

Overweight and Obesity clinical trials

40 of 116 indexed Overweight and Obesity trials are currently recruiting.

116 US clinical trials · 40 currently recruiting

Overweight and Obesity is the subject of 116 registered US clinical trials on ClinicalTrials.gov, 40 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 8 of these trials.

The research picture

Overweight and Obesity has 116 registered US clinical trials, 40 of them open to new participants right now, about 34% of the total.

40
recruiting participants now
34%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
8
top sponsor: University of Colorado, Denver
Phase 14Phase 28Phase 31Phase 41

Active & Recent Trials

116 total, page 2 of 3

ACTIVE NOT RECRUITING NA 125 participants

Daily Caloric Restriction in ADPKD

University of Colorado, Denver

NCT04907799

ACTIVE NOT RECRUITING 100 participants

An Open Label 100 Person Study Evaluating a Natural Supplement for Weight Loss and Fat Loss.

Prostasis, LLC, dba Tonum Health

NCT07152470

ACTIVE NOT RECRUITING NA 70 participants

Fitbit Device Use in Overweight Pregnancy

University of Arizona

NCT06226597

ACTIVE NOT RECRUITING NA 64 participants

Training Effects on Fuel Metabolism

University of Minnesota

NCT02150889

ACTIVE NOT RECRUITING NA 60 participants

Targeting Weight and Shape Concern Among Women with High Body Weight

The Miriam Hospital

NCT05845866

ACTIVE NOT RECRUITING Phase 4 60 participants

Use of Empagliflozin to Treat Prediabetes

Oregon State University

NCT05426525

ACTIVE NOT RECRUITING NA 57 participants

TREAT to Improve Cardiometabolic Health

Columbia University

NCT04465721

ACTIVE NOT RECRUITING NA 52 participants

Fasting ENHANCE Pilot Study

University of Florida

NCT05732935

ACTIVE NOT RECRUITING NA 22 participants

Telehealth Weight Loss Program for Breast Cancer Survivors

Abramson Cancer Center at Penn Medicine

NCT04855552

ACTIVE NOT RECRUITING NA 20 participants

Developing a Weight Management Class as a Recruitment Tool for an Online Weight Loss Program to Rural Illinois Residents

University of Illinois at Urbana-Champaign

NCT06406985

ACTIVE NOT RECRUITING NA 20 participants

Time and Nutrient-Dependent Effects of Aerobic Exercise on Metabolism in Adults (TANDEM Study)

University of Colorado, Denver

NCT06311487

ACTIVE NOT RECRUITING NA 17 participants

Postprandial Inflammation and Nuts (PIN) in Older Adults

Rutgers, The State University of New Jersey

NCT06348771

ACTIVE NOT RECRUITING NA 16 participants

Dietary Oils to Sustain Energy Study

Ohio State University

NCT04975763

ACTIVE NOT RECRUITING NA 13 participants

Improving Metabolic & Mental Health in Female Healthcare Shift Workers

Auburn University

NCT06158204

ACTIVE NOT RECRUITING NA 8 participants

Evaluating the Influence of Diet-induced Weight Loss on Fat (Adipose) Tissue's Insulin Sensitivity and Testosterone Synthesis in Women With Overweight or Obesity, Insulin Resistance, and Hyperandrogenemia

University of Missouri-Columbia

NCT06998238

COMPLETED NA 1,984 participants

SWITCH Implementation Effectiveness Trial

Iowa State University

NCT04045288

COMPLETED NA 1,250 participants

Evaluation of the BOKS Before-school Physical Activity Program

Massachusetts General Hospital

NCT03190135

COMPLETED NA 730 participants

NOURISH+: Nourishing Our Understanding of Role Modeling to Improve Support and Health

Virginia Commonwealth University

NCT01361243

COMPLETED NA 630 participants

Train Your Brain - Executive Function

USDA Grand Forks Human Nutrition Research Center

NCT05938894

COMPLETED NA 578 participants

Healthy Mothers-Healthy Children Nutrition

University of Miami

NCT03866902

COMPLETED NA 502 participants

Promoting Lifestyle Change Via Tailored mHealth Feedback to Improve Health

University of Pittsburgh

NCT03367936

COMPLETED NA 413 participants

Fit and Strong! Plus Comparative Effectiveness Trial

University of Illinois at Chicago

NCT03180008

COMPLETED NA 396 participants

Daily Self-Weighing for Obesity Management in Primary Care

University of Alabama at Birmingham

NCT04044794

COMPLETED NA 291 participants

Randomized Trial Of Achieving Healthy Lifestyles In Psych Rehabilitation

Johns Hopkins University

NCT00902694

COMPLETED NA 200 participants

Tailored Lifestyle Intervention in Obese Adults Within Primary Care Practice - Choose to Lose

Memorial Hospital of Rhode Island

NCT01542671

COMPLETED Phase 1 180 participants

Healthy Summer Learners

University of South Carolina

NCT03321071

COMPLETED Phase 2 179 participants

A Study of LY3305677 Compared With Placebo in Adult Participants With Obesity or Overweight

Eli Lilly and Company

NCT06124807

COMPLETED NA 177 participants

Madres Para la Salud (Mothers for Health)

Arizona State University

NCT01908959

COMPLETED NA 175 participants

Nonalcoholic Fatty Liver Disease and Atherosclerotic Risk in Children

Augusta University

NCT02383485

COMPLETED NA 167 participants

Strong People Strength Training Study

Cornell University

NCT04203563

COMPLETED NA 148 participants

Heart Health 4 New Moms: A Randomized Trial in the First Year After Preeclampsia

University of Pittsburgh

NCT03749746

COMPLETED 139 participants

Circadian Timing, Information Processing and Energy Balance Study

University of Utah

NCT04759755

COMPLETED NA 139 participants

Healthy Eating, Activity and Reduction of Teen Stress

Kent State University

NCT04038684

COMPLETED NA 128 participants

Behavioral Treatment for Weight Loss

Drexel University

NCT00746265

COMPLETED NA 120 participants

IgG-mediated Food Test for Weight Loss

University of Miami

NCT01592071

COMPLETED Phase 2 120 participants

A Study to Evaluate the Safety and Efficacy of NG101 in Adult Participants Receiving a Glucagon-like Peptide-1 (GLP-1) Agonist

Neurogastrx

NCT06500429

COMPLETED NA 102 participants

Healthy Body Healthy Souls in the Marshallese Population

University of Arkansas

NCT03377244

COMPLETED NA 100 participants

UCSD Get Fit, Be Fit Study

University of California, San Diego

NCT03387709

COMPLETED NA 99 participants

PATH to Health: An Exploration of Digital Behavioral Weight Loss Approaches

University of North Carolina, Chapel Hill

NCT05929469

COMPLETED NA 87 participants

Pilot Study on the Effects of a Plant-Strong Diet on Cardiovascular Risk Factors

Phoenix VA Health Care System

NCT03330548

COMPLETED NA 78 participants

Dairy Foods and Weight Loss

USDA, Western Human Nutrition Research Center

NCT00858312

COMPLETED NA 76 participants

Safety and Efficacy of the SMART Device for Overweight and Obese Adults

Scientific Intake Limited

NCT02119299

COMPLETED NA 71 participants

Evaluation of a Lifestyle Medicine Practice

Ohio University

NCT03739034

COMPLETED NA 69 participants

A Trial to Assess Steviol Glycosides on Acute Appetite Hormone Release

Midwest Center for Metabolic and Cardiovascular Research

NCT05287906

COMPLETED NA 68 participants

ACT1ON Phase 2 (SMART Pilot) and Phase 3 (Efficacy Trial Development)

University of North Carolina, Chapel Hill

NCT03651622

COMPLETED NA 67 participants

Novel Executive Function Training for Obesity

University of California, San Diego

NCT03724396

COMPLETED NA 60 participants

Microalgae Extract Phaeosol Combined to Exercise in Healthy Overweight Women : Efficacy on Body Weight Management

Microphyt

NCT04761406

COMPLETED NA 58 participants

Optimizing Weight Loss Outcomes Through Body Image Enhancement

Texas Tech University

NCT05090293

COMPLETED NA 50 participants

Cognitive Behavioral Therapy for Adolescent Binge Eating and Loss of Control Eating

Yale University

NCT04088097

COMPLETED NA 41 participants

Improving Emotion Regulation Skills Among Adolescents Attempting to Lose Weight

Rhode Island Hospital

NCT03393221

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Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 8
Phase 3 1
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Overweight and Obesity Trial Landscape

116 indexed Overweight and Obesity studies · 40 recruiting (34%).

Phase mix: 2 late (III/IV) vs 12 early (I/II).

Top sponsor: University of Colorado, Denver (8 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Overweight and Obesity?

PlainTrial tracks 116 US clinical trials for Overweight and Obesity, of which 40 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Overweight and Obesity?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.