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ClinicalTrials.gov 40 recruiting now official registry

Overweight and Obesity clinical trials

40 of 116 indexed Overweight and Obesity trials are currently recruiting.

116 US clinical trials · 40 currently recruiting

Overweight and Obesity is the subject of 116 registered US clinical trials on ClinicalTrials.gov, 40 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 8 of these trials.

The research picture

Overweight and Obesity has 116 registered US clinical trials, 40 of them open to new participants right now, about 34% of the total.

40
recruiting participants now
34%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
8
top sponsor: University of Colorado, Denver
Phase 14Phase 28Phase 31Phase 41

Active & Recent Trials

116 total, page 1 of 3

RECRUITING Phase 2 1,785 participants

Taxi ROADmAP (Realizing Optimization Around Diet And Physical Activity)

Memorial Sloan Kettering Cancer Center

NCT05770570

RECRUITING NA 1,780 participants

'Ai Pono Cooking Demonstrations

University of Hawaii

NCT06526650

RECRUITING NA 828 participants

Intensive Glycemic Targets in Overweight and Obese Women With Gestational Diabetes

Indiana University

NCT05124808

RECRUITING NA 736 participants

Becoming United in Lifestyle Decisions

University of Connecticut

NCT05796141

RECRUITING Phase 3 720 participants

Food Prescriptions to Promote Affordable Diets

Kaiser Permanente

NCT05309395

RECRUITING NA 664 participants

Community Engagement Alliance Against Disparities

Johns Hopkins University

NCT06607341

RECRUITING NA 616 participants

Optimal Digital Weight Loss Treatment for Rural Individuals

University of South Carolina

NCT06105957

RECRUITING NA 400 participants

Functional Improvement in OSA and COPD With a Telehealth LifeStyle and Exercise Intervention

Seattle Institute for Biomedical and Clinical Research

NCT06390345

RECRUITING NA 375 participants

Water Intake and Weight Control in Older Adults

Virginia Polytechnic Institute and State University

NCT05843318

RECRUITING NA 360 participants

Healthy for Two-Home Visiting (H42-HV): Health Coaching for Pregnant Women

Johns Hopkins University

NCT05619705

RECRUITING Phase 2 360 participants

Social Determinants and a Diabetes Prevention Program Tailored for African Americans

University of Missouri, Kansas City

NCT05301413

RECRUITING NA 300 participants

Pregnancy Exercise Mode Effect on Childhood Obesity

East Carolina University

NCT04805502

RECRUITING NA 228 participants

Neuronal and Behavioral Effects of an Implicit Priming Approach to Improve Eating Behaviors in Obesity

University of Colorado, Denver

NCT05107908

RECRUITING NA 210 participants

PILI 'Āina Household

University of Hawaii

NCT06526273

RECRUITING Phase 2 180 participants

Control Systems Engineering for Weight Loss Maintenance

The Miriam Hospital

NCT06244888

RECRUITING NA 162 participants

Early vs. Late Time Restricted Eating vs. Daily Caloric Restriction

University of Colorado, Denver

NCT05870982

RECRUITING NA 150 participants

Role of Microvascular Insulin Resistance and Cardiorespiratory Fitness Diabetes

University of Colorado, Denver

NCT04791371

RECRUITING NA 148 participants

An Acceptance-Based Healthy Lifestyle Intervention for Diverse Adolescents

Drexel University

NCT06147973

RECRUITING NA 144 participants

Healthy Mom Zone Gestational Weight Gain Management Intervention 2.0

Penn State University

NCT05807594

RECRUITING NA 128 participants

Timing Intervention of Morning Versus Evening Exercise

University of Colorado, Denver

NCT05153252

RECRUITING NA 125 participants

Lifestyle Intervention for Healthy Change

Augusta University

NCT05956574

RECRUITING NA 114 participants

Cooking Skills to Improve Long-Term Weight Loss in Young Adults With Intellectual Disabilities

University of Kansas Medical Center

NCT06961591

RECRUITING Phase 2 100 participants

Metformin IN Asthma for Overweight and Obese Individuals (MINA)

Johns Hopkins University

NCT06273072

RECRUITING NA 90 participants

Cottonseed Oil Versus Matched PUFA Effects

University of Georgia

NCT06382298

RECRUITING NA 80 participants

Dose Response Effects of Pecan Consumption

University of Georgia

NCT05949879

RECRUITING 80 participants

Breathing & Blood Pressure

Florida State University

NCT05632406

RECRUITING NA 80 participants

Cottonseed Oil Dose Response

University of Georgia

NCT05686954

RECRUITING NA 80 participants

Effects of Watermelon or Low-fat Cookie Consumption on Wellness

San Diego State University

NCT06323070

RECRUITING NA 75 participants

Intermittent Cottonseed Oil Consumption

University of Georgia

NCT07246408

RECRUITING 70 participants

Associations Between the Microbiome, Skeletal Muscle Perfusion, and Fitness Status

University of Virginia

NCT06009276

RECRUITING NA 70 participants

Effect of Sleep Extension on Ceramides in People with Overweight and Obesity

University of Utah

NCT06180837

RECRUITING Phase 2 66 participants

Tirzepatide: Reversal of Lipotoxicity and Adipose Tissue Dysfunction in Humans With Overweight/Obesity

Stanford University

NCT05912621

RECRUITING NA 64 participants

A Pilot Factorial Trial of an Integrated Lifestyle Intervention

University of Colorado, Denver

NCT06116435

RECRUITING NA 60 participants

Time-restricted Eating for Postpartum Weight Loss

University of Alabama at Birmingham

NCT06491537

RECRUITING NA 58 participants

Testing the Adipose Expandability Hypothesis in Vivo During Overfeeding

Pennington Biomedical Research Center

NCT04583514

RECRUITING NA 48 participants

Assessing the Value of Avocados on Glycemic Control in Type 2 Diabetes

Pennington Biomedical Research Center

NCT05958368

RECRUITING Phase 1 32 participants

Human Models of Selective Insulin Resistance: Alpelisib, Part I

Columbia University

NCT06354088

RECRUITING NA 30 participants

Efficacy of mHealth Applications in Weight Management in a Population Affected by Overweight or Obesity

San Diego State University

NCT05726942

RECRUITING 30 participants

Role of Caveolin 1 (CAV-1) Deficiency in Response to Glucagon-like Peptide 1 (GLP-1) Receptor Agonist Treatment

Brigham and Women's Hospital

NCT06069622

RECRUITING NA 20 participants

Circadian Intervention to Improve Cardiometabolic Health

University of Utah

NCT05943626

ACTIVE NOT RECRUITING NA 1,000 participants

Developing a Learning COmmunity to Increase eNgagemeNt and Enrollment in Cardiovascular Clinical Trials (CONNECT)

Johns Hopkins University

NCT06347484

ACTIVE NOT RECRUITING 500 participants

Biological Sample Repository for Gastrointestinal Disorders

Pichamol Jirapinyo, MD, MPH

NCT05874726

ACTIVE NOT RECRUITING NA 406 participants

Project Health: Enhancing Effectiveness of a Dissonance-Based Obesity Prevention Program

Oregon Research Institute

NCT03710746

ACTIVE NOT RECRUITING NA 380 participants

Using Signos mHealth Platform in Adults for Weight Management

Signos

NCT06214221

ACTIVE NOT RECRUITING Phase 1 349 participants

A Trial to Compare the Extent to Which Maridebart Cafraglutide (AMG 133) is Made Available in the Body When Administered Using Two Subcutaneous Presentations

Amgen

NCT07313761

ACTIVE NOT RECRUITING NA 300 participants

Solutions for Hunger and Regulating Eating

University of California, San Diego

NCT05004883

ACTIVE NOT RECRUITING NA 273 participants

Stepping Into Lifestyle Changes

University of Alabama at Birmingham

NCT05625321

ACTIVE NOT RECRUITING NA 229 participants

Choosing Healthy Activities and Lifestyle Management Through Portal Support

University of Tennessee

NCT05410353

ACTIVE NOT RECRUITING NA 208 participants

Enhancing BodyWorks: a Canine Health Literacy Module

Children's Hospital Los Angeles

NCT04516252

ACTIVE NOT RECRUITING NA 181 participants

Healthy Living After Knee Replacement

University of South Carolina

NCT05190666

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Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 8
Phase 3 1
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Overweight and Obesity Trial Landscape

116 indexed Overweight and Obesity studies · 40 recruiting (34%).

Phase mix: 2 late (III/IV) vs 12 early (I/II).

Top sponsor: University of Colorado, Denver (8 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Overweight and Obesity?

PlainTrial tracks 116 US clinical trials for Overweight and Obesity, of which 40 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Overweight and Obesity?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.