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ClinicalTrials.gov 13 recruiting now official registry

Oropharynx Cancer clinical trials

13 of 27 indexed Oropharynx Cancer trials are currently recruiting.

27 US clinical trials · 13 currently recruiting

Oropharynx Cancer is the subject of 27 registered US clinical trials on ClinicalTrials.gov, 13 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 3 of these trials.

The research picture

Oropharynx Cancer has 27 registered US clinical trials, 13 of them open to new participants right now, about 48% of the total.

13
recruiting participants now
48%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
3
top sponsor: Memorial Sloan Kettering Cancer Center
Phase 11Phase 214Phase 32

Active & Recent Trials

27 total, page 1 of 1

RECRUITING 1,500 participants

Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy

University Hospital Freiburg

NCT05337631

RECRUITING NA 532 participants

Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy

Medical University of South Carolina

NCT05793151

RECRUITING Phase 2 150 participants

Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer

Heath Skinner

NCT05388773

RECRUITING NA 120 participants

Radiotherapy Dose De-escalation in HPV-Associated Cancers of the Oropharynx

Duke University

NCT04667585

RECRUITING Phase 2 61 participants

Selective Adjuvant Therapy for HPV-mediated Oropharynx SCCs Based on Residual Circulating Tumor DNA Levels (SAVAL)

University of Maryland, Baltimore

NCT06088381

RECRUITING Phase 2 40 participants

A Study of Sacituzumab Govitecan in Combination With Cetuximab in People With Head and Neck Squamous Cell Cancer (HNSCC)

Memorial Sloan Kettering Cancer Center

NCT07063212

RECRUITING Phase 2 30 participants

A Study on Using Cell-Free Tumor DNA (ctDNA) Testing to Decide When to StartRoutine Treatment in People With Human Papilloma Virus (HPV)- Associated Oropharynx Cancer (OPC)

Memorial Sloan Kettering Cancer Center

NCT05307939

RECRUITING NA 30 participants

De-escalation of Adjuvant Radiation for Low-Risk HPV Oropharyngeal Cancers

Georgetown University

NCT06554158

RECRUITING Phase 2 29 participants

Neoadjuvant Immunoradiotherapy With Evorpacept and Pembrolizumab in HPVOPC (Human Papilloma Virus Oropharynx Cancer)

University of California, San Diego

NCT05787639

RECRUITING Phase 2 28 participants

Testing Less Intensive Radiation With Chemotherapy to Treat Low-risk Patients With HPV-positive Oropharyngeal Cancer

University of Missouri-Columbia

NCT04444869

RECRUITING Phase 2 22 participants

Lymphoscintigraphy Directed Elective Neck Radiation for p16+ Favorable Risk Oropharynx Cancer

Fox Chase Cancer Center

NCT05800574

RECRUITING Phase 2 20 participants

E7 TCR-T Cell Immunotherapy for Human Papillomavirus (HPV) Associated Cancers

Christian Hinrichs

NCT05686226

RECRUITING NA 20 participants

Dose Adjusted Chemoradiotherapy in HPV-Associated Oropharynx Cancer of the Elderly

Omar Mahmoud

NCT06309225

ACTIVE NOT RECRUITING 150 participants

De-Escalation Protocol Of HPV Mediated Oropharyngeal Squamous Cell Carcinoma

Nebraska Methodist Health System

NCT04638465

ACTIVE NOT RECRUITING Phase 2 52 participants

Selective Avoidance of Nodal VolumEs at Minimal Risk (GCC 20110)

University of Maryland, Baltimore

NCT04609280

ACTIVE NOT RECRUITING NA 40 participants

The ENHANCE Study: Exercise and Nutrition in Head And Neck CancEr Survivors

H. Lee Moffitt Cancer Center and Research Institute

NCT05798780

ACTIVE NOT RECRUITING Phase 2 39 participants

Carboplatin, Nab-Paclitaxel, Durvalumab Before Surgery and Adjuvant Therapy in Head and Neck Squamous Cell Carcinoma

UNC Lineberger Comprehensive Cancer Center

NCT03174275

ACTIVE NOT RECRUITING Phase 2 19 participants

Trial of Individualized Adaptive RT in HPV-related High Risk Oropharynx Cancer

University of Michigan Rogel Cancer Center

NCT06234748

COMPLETED Phase 3 100 participants

Effects of Oral Aloe Vera Juice on Chemotherapy and Radiation-induced Oral Mucositis and Esophagitis

Covenant Health Cancer Center

NCT05369234

COMPLETED Phase 2 91 participants

Individualized Adaptive De-escalated Radiotherapy for HPV-related Oropharynx Cancer

University of Michigan Rogel Cancer Center

NCT03416153

COMPLETED Phase 2 78 participants

Pembrolizumab Combined With Cetuximab for Treatment of Recurrent/Metastatic Head & Neck Squamous Cell Carcinoma

University of California, San Diego

NCT03082534

COMPLETED Phase 3 65 participants

Gabapentin for the Reduction of Radiation Therapy Induced Pain During the Treatment of Oropharyngeal Cancer

Henry Ford Health System

NCT03269344

COMPLETED Phase 2 64 participants

Adaptive Radiotherapy for Head and Neck Cancer

Memorial Sloan Kettering Cancer Center

NCT03096808

COMPLETED Phase 1 59 participants

Pembrolizumab in Combination With CRT for LA-SCCHN

Sanford Health

NCT02586207

COMPLETED NA 40 participants

Functional Sparing of Salivary Glands Using MRI Sialography for Patients Undergoing Definitive Radiation Therapy for Head and Neck Cancers of the Oropharynx

UNC Lineberger Comprehensive Cancer Center

NCT03418792

COMPLETED NA 30 participants

Outcomes of Prophylactic Swallowing Therapy in Patients Undergoing Definitive Chemoradiation for Head and Neck Cancer

University of Miami

NCT03435471

COMPLETED 24 participants

PET-MRI Assessment of Early Tumor Response to Predict Outcomes of HPV-Positive Oropharynx Cancer Patients

University of Wisconsin, Madison

NCT03342378

Phase Distribution

PhaseTrial count
Phase 1 1
Phase 2 14
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Oropharynx Cancer Trial Landscape

27 indexed Oropharynx Cancer studies · 13 recruiting (48%).

Phase mix: 2 late (III/IV) vs 15 early (I/II).

Top sponsor: Memorial Sloan Kettering Cancer Center (3 trials), 9 others listed. 27 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Oropharynx Cancer?

PlainTrial tracks 27 US clinical trials for Oropharynx Cancer, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Oropharynx Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.