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NCT05787639 · ClinicalTrials.gov registry record · Phase 2
Neoadjuvant Immunoradiotherapy With Evorpacept and Pembrolizumab in HPVOPC (Human Papilloma Virus Oropharynx Cancer)
A Phase 2 study of Oropharynx Cancer, sponsored by University of California, San Diego.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 29
- Enrollment target
- 3
- Study locations
NCT05787639 is a Phase 2 study of Oropharynx Cancer that is actively recruiting participants, run by University of California, San Diego. The registered enrollment target is 29 participants, below the 131-participant average among 26 other Oropharynx Cancer trials with a reported enrollment target (78% lower). The trial reports 3 study locations across 2 states.
The verdict
NCT05787639, a Phase 2 study of Oropharynx Cancer, is actively recruiting participants, sponsored by University of California, San Diego.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 29 participants
- Enrollment target
- 3
- Study locations
Study Summary
The majority of head and neck cancer patients do not respond to immunotherapies, and clinical responses are often not durable. However, targeting tumors with stereotactic radiation in combination with immunotherapy while sparing draining lymphatics enhances anticancer immunity, resulting in dramatic response in HPV (Human Papilloma Virus) virus related cancers of the throat. This trial will leverage targeted tumor radiation and immunotherapy in advance of standard surgical therapy to improve the response of HPV (Human Papilloma Virus) throat cancer to radiation and immunotherapy.
Conditions Studied
Interventions
- DRUG Evorpacept
Study Locations (3)
Oregon
- Providence Health & Services - Portland
- Oregon Health and Science University - Portland
California
- UC San Diego Moores Cancer Center - La Jolla
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 29 participants |
| Start Date | 2024-02-20 |
| Est. Completion | 2028-05-30 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05787639
The ClinicalTrials.gov registry entry for NCT05787639 describes a study currently listed as recruiting, categorized as Phase 2. The registered enrollment target is 29 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 131-participant average among 26 other Oropharynx Cancer trials with a reported enrollment target (78% lower). The listed sponsor is University of California, San Diego, which has 775 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Oropharynx Cancer appearing as the primary indexed condition, and to 1 intervention - of which Evorpacept is the first listed.
NCT05787639 reports 3 study locations spanning 2 distinct geographic areas - top geographies include Oregon, California.
Frequently Asked Questions
What is clinical trial NCT05787639 about?
NCT05787639 is a clinical study titled "Neoadjuvant Immunoradiotherapy With Evorpacept and Pembrolizumab in HPVOPC (Human Papilloma Virus Oropharynx Cancer)". The majority of head and neck cancer patients do not respond to immunotherapies, and clinical responses are often not durable. However, targeting tumors with stereotactic radiation in combination with immunotherapy while sparing draining lymphatics enhances anticancer immunity, resulting in dramatic...
What is the current status of trial NCT05787639?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 29 participants. The study started on 2024-02-20. Estimated completion is 2028-05-30.
What conditions does trial NCT05787639 study?
This clinical trial studies the following conditions: Oropharynx Cancer.
What interventions are being tested in trial NCT05787639?
The interventions under investigation include: Evorpacept (DRUG).
Who is sponsoring clinical trial NCT05787639?
This trial is sponsored by University of California, San Diego, which has 775 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05787639 being conducted?
This trial has 3 study locations across California, Oregon. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.