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Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy
NCT05337631 · View on ClinicalTrials.gov ↗
Study Summary
The number of elderly head-and-neck squamous cell carcinoma (HNSCC) patients is increasing; however, the evidence regarding the ideal treatment for this often vulnerable and frail patient cohort is limited. Although the benefit of concomitant chemotherapy has been reported to decrease in elderly HNSCC patients based on the MACH-NC meta-analysis, it remains unknown whether state-of-the art radiotherapy techniques such as intensity-modulated radiotherapy (IMRT), modern supportive treatments and alternative chemotherapy fractionation (e.g., cisplatin weekly) may have altered this observation. The objective of this retrospective multinational multicenter study is to determine the oncological outcomes of elderly patients (≥65 years) with locally advanced HNSCCs undergoing definitive (chemo-)radiation and to investigate the influence of concomitant chemotherapy on overall survival and progression-free survival after adjusting for potential confounder variables such as age, performance status and comorbidity burden.
Conditions Studied
Study Locations (18)
Other
- Radiation Oncology Department, German Oncology Center — Limassol
- Brno University Hospital — Brno
- Department of Radiooncology and Radiotherapy, Charité-Universitätsmedizin Berlin — Berlin
- Department of Radiation Oncology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg — Erlangen
- Department of Radiotherapy and Oncology, Goethe-University Frankfurt am Main — Frankfurt
- University of Giessen — Giessen
- Martin-Luther-Universität Halle-Wittenberg — Halle
- Jena University Hospital — Jena
- Department of Radiation Oncology, University Hospital Schleswig-Holstein — Kiel
- Department of Radiation Oncology, University Medical Center Leipzig — Leipzig
- Department of Radiation Oncology, University Medical Center Mainz — Mainz
- Department of Radiation Oncology, University Hospital, LMU Munich — Munich
- Department of Radiation Oncology, University Hospital Würzburg — Würzburg
- Department of Radiation Oncology, University Hospital Zurich (USZ), University of Zurich (UZH) — Zurich
Ohio
- Department of Radiation Oncology, Case Western Reserve University — Cleveland
- Division of Radiation Oncology, The Ohio State University Wexner — Columbus
Maryland
- Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine — Baltimore
New York
- Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai — New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,500 participants |
| Start Date | 2021-06-01 |
| Est. Completion | 2026-12-31 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05337631
The ClinicalTrials.gov registry entry for NCT05337631 describes a study currently listed as recruiting. It is categorized as an unspecified phase, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 1,500 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University Hospital Freiburg, which has 1 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 5 conditions, with Oropharynx Cancer appearing as the primary indexed condition, and to 0 interventions. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT05337631 reports 18 study locations spanning 4 distinct geographic areas — top geographies include Other, Ohio, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT05337631 about?
NCT05337631 is a clinical study titled "Special Care Patterns for Elderly HNSCC Patients Undergoing Radiotherapy". The number of elderly head-and-neck squamous cell carcinoma (HNSCC) patients is increasing; however, the evidence regarding the ideal treatment for this often vulnerable and frail patient cohort is limited. Although the benefit of concomitant chemotherapy has been reported to decrease in elderly HNS...
What is the current status of trial NCT05337631?
This trial is currently recruiting. The enrollment target is 1,500 participants. The study started on 2021-06-01. Estimated completion is 2026-12-31.
What conditions does trial NCT05337631 study?
This clinical trial studies the following conditions: Oropharynx Cancer, HNSCC, Oral Cavity Cancer, Larynx Cancer, Hypopharynx Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
Who is sponsoring clinical trial NCT05337631?
This trial is sponsored by University Hospital Freiburg, which has 1 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT05337631 being conducted?
This trial has 18 study locations across Maryland, New York, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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