Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 3

A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)

NCT07190248 · View on ClinicalTrials.gov ↗

Study Summary

Researchers want to learn if the study medicines calderasib and subcutaneous (SC) pembrolizumab can be used to treat non-small cell lung cancer (NSCLC) when given together. Calderasib is a targeted therapy for the KRAS G12C mutation. The goal of this study is to learn if people who receive calderasib with SC pembrolizumab live longer without the cancer growing or spreading than in people who receive SC pembrolizumab with chemotherapy.

Conditions Studied

Interventions

  • DRUG Carboplatin
  • DRUG Cisplatin
  • DRUG Pemetrexed
  • DRUG Calderasib
  • BIOLOGICAL Pembrolizumab (+) Berahyaluronidase alfa

Study Locations (20)

Other

  • Hospital Italiano de Cordoba ( Site 0308) — Córdoba
  • CEMAIC ( Site 0309) — Córdoba
  • IBCC - Núcleo de Pesquisa e Ensino ( Site 0417) — São Paulo

Buenos Aires

  • Instituto Alexander Fleming ( Site 0311) — Ciudad Autónoma de Buenos Aires
  • Instituto de Investigaciones Clinicas Mar del Plata ( Site 0300) — Mar del Plata

New South Wales

  • Genesis Care- Campbelltown ( Site 2907) — Campbelltown
  • Northern Beaches Hospital ( Site 2905) — Frenchs Forest

Queensland

  • The Prince Charles Hospital ( Site 2903) — Brisbane
  • Mater Hospital Brisbane ( Site 2906) — South Brisbane

Region M. de Santiago

  • Centro de Estudios Clínicos SAGA ( Site 0503) — Santiago
  • Bradfordhill ( Site 0501) — Santiago

Alabama

  • Central Alabama Research ( Site 0108) — Birmingham

Connecticut

  • Stamford Hospital ( Site 0126) — Stamford

Florida

  • Mount Sinai Cancer Center ( Site 0137) — Miami Beach

Trial Details

FieldValue
Enrollment Target 675 participants
Start Date 2025-10-08
Est. Completion 2032-08-06
Phase Phase 3

Sponsor

Merck Sharp & Dohme

741 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07190248

The ClinicalTrials.gov registry entry for NCT07190248 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 675 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Merck Sharp & Dohme, which has 741 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Non-small Cell Lung Cancer appearing as the primary indexed condition, and to 5 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07190248 reports 20 study locations spanning 14 distinct geographic areas — top geographies include Other, Buenos Aires, New South Wales. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07190248 about?

NCT07190248 is a clinical study titled "A Clinical Study of Calderasib (MK-1084) and Other Treatments for Participants With Non-Small Cell Lung Cancer (MK-1084-007/KANDLELIT-007)". Researchers want to learn if the study medicines calderasib and subcutaneous (SC) pembrolizumab can be used to treat non-small cell lung cancer (NSCLC) when given together. Calderasib is a targeted therapy for the KRAS G12C mutation. The goal of this study is to learn if people who receive calderas...

What is the current status of trial NCT07190248?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 675 participants. The study started on 2025-10-08. Estimated completion is 2032-08-06.

What conditions does trial NCT07190248 study?

This clinical trial studies the following conditions: Non-small Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07190248?

The interventions under investigation include: Carboplatin (DRUG), Cisplatin (DRUG), Pemetrexed (DRUG), Calderasib (DRUG), Pembrolizumab (+) Berahyaluronidase alfa (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07190248?

This trial is sponsored by Merck Sharp & Dohme, which has 741 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07190248 being conducted?

This trial has 20 study locations across Alabama, Connecticut, Florida, Maine, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial