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NCT00071435 · ClinicalTrials.gov registry record
Brain Function in Primary Lateral Sclerosis
A clinical trial of Motor Neuron Disease, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- Completed
- Registry status
- 36
- Enrollment target
- 1
- Study location
NCT00071435: Completed study of Motor Neuron Disease, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
NCT00071435 is a study of Motor Neuron Disease that has completed, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 36 participants, below the 528-participant average among 17 other Motor Neuron Disease trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00071435, a study of Motor Neuron Disease, has completed, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- COMPLETED
- Registry status
- 36 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will examine whether the motor cortex (the part of the brain that controls movement) works properly in patients with primary lateral sclerosis (PLS), a disorder in which voluntary movements are very slow. Healthy volunteers between 40 and 75 years of age and patients with ascending PLS (a subset of PLS) may be eligible for this study. Patients with ascending PLS have a slowing of finger-tapping movements that corresponds to a particular abnormality of certain neuronal (nerve cell) activity. Participants perform a finger-tapping reaction time exercise while brain wave activity (electroencephalography, or EEG) and muscle activity (electroymogram, or EMG) are measured. The subject is seated in front of a computer screen. A signal appears on the screen and the subject taps a key as quickly as possible in response to the signal. For the EEG, brain activity is recorded by placing electrodes (small metal discs) on the scalp with an electrode cap or glue-like substance. A conductive gel is used to fill the space between the electrodes and the scalp to make sure there is good contact between them. The brain waves are recorded while the subject taps his or her fingers very slowly. For the surface EMG, electrodes filled with a conductive gel are taped to the skin. Participants also undergo magnetic resonance imaging (MRI). This test uses a strong magnetic field and radio waves to obtain images of the brain. During the procedure, the subject lies still on a table that can slide in and out of the scanner - a narrow metal cylinder. Scanning time varies from 20 minutes to 3 hours, with most scans lasting between 45 and 90 minutes. Subjects can communicate with the MRI staff at all times during the scan and can ask to be moved out of the machine at any time.
Conditions Studied
Study Locations (1)
Maryland
- National Institute of Neurological Disorders and Stroke (NINDS) - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 36 participants |
| Start Date | 2003-10 |
| Est. Completion | 2006-02 |
What the finished NCT00071435 record still lists
NCT00071435 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 36 participants, a relatively small participant target, below the 528-participant average among 17 other Motor Neuron Disease trials with a reported enrollment target (93% lower).
The record links to 1 condition, with Motor Neuron Disease appearing as the primary indexed condition, and to 0 interventions.
NCT00071435 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT00071435 about?
NCT00071435 is a clinical study titled "Brain Function in Primary Lateral Sclerosis". This study will examine whether the motor cortex (the part of the brain that controls movement) works properly in patients with primary lateral sclerosis (PLS), a disorder in which voluntary movements are very slow. Healthy volunteers between 40 and 75 years of age and patients with ascending PLS (...
What is the current status of trial NCT00071435?
This trial is currently completed. The enrollment target is 36 participants. The study started on 2003-10. Estimated completion is 2006-02.
What conditions does trial NCT00071435 study?
This clinical trial studies the following conditions: Motor Neuron Disease.
Who is sponsoring clinical trial NCT00071435?
This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00071435 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT00071435's enrollment target sits among peer trials
36 11th of 17 higher than 7 of 17 other Motor Neuron Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Motor Neuron Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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