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NCT05354622 · ClinicalTrials.gov registry record
Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)
A clinical trial of Movement Disorders and Motor Neuron Disease, sponsored by Boston Children's Hospital.
- Recruiting
- Registry status
- 200
- Enrollment target
- 1
- Study location
NCT05354622 is a study of Movement Disorders and Motor Neuron Disease that is actively recruiting participants, run by Boston Children's Hospital. The registered enrollment target is 200 participants, below the 1,060-participant average among 26 other Movement Disorders trials with a reported enrollment target (81% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05354622, a study of Movement Disorders and Motor Neuron Disease, is actively recruiting participants, sponsored by Boston Children's Hospital.
- RECRUITING
- Registry status
- 200 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of the HSP Sequencing Initiative is to better understand the role of genetics in hereditary spastic paraplegia (HSP) and related disorders. The HSPs are a group of more than 80 inherited neurological diseases that share the common feature of progressive spasticity. Collectively, the HSPs present the most common cause of inherited spasticity and associated disability, with a combined prevalence of 2-5 cases per 100,000 individuals worldwide. In childhood-onset forms, initial symptoms are often non-specific and many children may not receive a diagnosis until progressive features are recognized, often leading to a significant diagnostic delay. Genetic testing in children with spastic paraplegia is not yet standard practice. In this study, the investigators hope to identify genetic factors related to HSP. By identifying different genetic factors, the investigators hope that over time we can develop better treatments for sub-categories of HSP based on cause.
Conditions Studied
Study Locations (1)
Massachusetts
- Boston Children's Hospital - Boston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2022-04-25 |
| Est. Completion | 2027-04-29 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05354622
The ClinicalTrials.gov registry entry for NCT05354622 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 200 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,060-participant average among 26 other Movement Disorders trials with a reported enrollment target (81% lower). The listed sponsor is Boston Children's Hospital, which has 462 total studies on file at ClinicalTrials.gov.
The record links to 6 conditions, with Movement Disorders appearing as the primary indexed condition, and to 0 interventions.
NCT05354622 reports 1 study location spanning 1 distinct geographic area - top geographies include Massachusetts.
Frequently Asked Questions
What is clinical trial NCT05354622 about?
NCT05354622 is a clinical study titled "Hereditary Spastic Paraplegia Genomic Sequencing Initiative (HSPseq)". The purpose of the HSP Sequencing Initiative is to better understand the role of genetics in hereditary spastic paraplegia (HSP) and related disorders. The HSPs are a group of more than 80 inherited neurological diseases that share the common feature of progressive spasticity. Collectively, the HSPs...
What is the current status of trial NCT05354622?
This trial is currently recruiting. The enrollment target is 200 participants. The study started on 2022-04-25. Estimated completion is 2027-04-29.
What conditions does trial NCT05354622 study?
This clinical trial studies the following conditions: Movement Disorders, Motor Neuron Disease, Neurodegenerative Diseases, Spasticity, Muscle, Pediatric Disorder.
Who is sponsoring clinical trial NCT05354622?
This trial is sponsored by Boston Children's Hospital, which has 462 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05354622 being conducted?
This trial has 1 study location across Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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