Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 3 recruiting now official registry

Anemia, Sickle Cell clinical trials

3 of 18 indexed Anemia, Sickle Cell trials are currently recruiting.

18 US clinical trials · 3 currently recruiting

Anemia, Sickle Cell is the subject of 18 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is Duke University, running 2 of these trials.

The research picture

Anemia, Sickle Cell has 18 registered US clinical trials, 3 of them open to new participants right now, about 17% of the total.

3
recruiting participants now
17%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
2
top sponsor: Duke University
Phase 14Phase 23Phase 41

Active & Recent Trials

18 total, page 1 of 1

RECRUITING Phase 2 310 participants

A Socio-ecological Approach for Improving Self-management in Adolescents With SCD

Children's Hospital Medical Center, Cincinnati

NCT06290401

RECRUITING Phase 1 184 participants

A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease

Bristol-Myers Squibb

NCT06481306

RECRUITING NA 120 participants

Metabolic and Hemodynamic Reserve in Pediatric SCA

Washington University School of Medicine

NCT04406818

ACTIVE NOT RECRUITING NA 150 participants

Therapeutic Response Evaluation and Adherence Trial (TREAT)

Children's Hospital Medical Center, Cincinnati

NCT02286154

ACTIVE NOT RECRUITING 102 participants

Epidemiology of Silent and Overt Strokes in Sickle Cell Disease

Vanderbilt University Medical Center

NCT03376893

ACTIVE NOT RECRUITING NA 24 participants

Telemedicine for Children With Sickle Cell Disease

Indiana University

NCT05087303

ACTIVE NOT RECRUITING Phase 1 3 participants

A Blood Stem Cell Transplant for Sickle Cell Disease

City of Hope Medical Center

NCT03249831

COMPLETED NA 279 participants

Effectiveness of a Computerized Tool (PAINRelieveIt) to Help Manage Pain Related to Sickle Cell Disease

University of Illinois at Chicago

NCT00600665

COMPLETED NA 279 participants

Implementing an Individualized Pain Plan (IPP) for ED Treatment of VOE's in Sickle Cell Disease

Duke University

NCT04584528

COMPLETED Phase 2 150 participants

Nitric Oxide Inhalation to Treat Sickle Cell Pain Crises

Mallinckrodt

NCT00094887

COMPLETED Phase 4 124 participants

Intranasal Fentanyl for Initial Treatment of a Vaso-occlusive Crisis

Montefiore Medical Center

NCT01482091

COMPLETED NA 91 participants

Feasibility and Efficacy of a Home-based, Computerized Cognitive Training Program in Pediatric Sickle Cell Disease

Steven J. Hardy

NCT02857023

COMPLETED NA 60 participants

MBSR for Pain Catastrophizing in SCD

Duke University

NCT02394587

COMPLETED 44 participants

A Self-Management Intervention for Youth With Sickle Cell Disease and Their Families: Phase I

Medical University of South Carolina

NCT03069430

COMPLETED Phase 1 36 participants

Examining Cognitive Function and Brain Abnormalities in Adults With Sickle Cell Disease - Pilot Intervention Study

UCSF Benioff Children's Hospital Oakland

NCT00850018

COMPLETED Phase 2 30 participants

Cord Blood Transplantation for Sickle Cell Anemia and Thalassemia

National Heart, Lung, and Blood Institute (NHLBI)

NCT00029380

COMPLETED Phase 1 17 participants

Hydroxyurea and EPO in Sickle Cell Disease

Julia Xu

NCT05451940

COMPLETED 5 participants

Quality of Life of Children With Sickle Cell Disease Who Are Getting Chronic Transfusions With a Lifeport

Children's Mercy Hospital Kansas City

NCT00246077

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 3
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Anemia, Sickle Cell Trial Landscape

18 indexed Anemia, Sickle Cell studies · 3 recruiting (17%).

Phase mix: 1 late (III/IV) vs 7 early (I/II).

Top sponsor: Duke University (2 trials), 9 others listed. 18 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Anemia, Sickle Cell?

PlainTrial tracks 18 US clinical trials for Anemia, Sickle Cell, of which 3 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Anemia, Sickle Cell?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.