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ClinicalTrials.gov 3 recruiting now early-phase tilt small index

Anemia, Sickle Cell: early-phase trial registry

3 of 18 indexed Anemia, Sickle Cell trials are currently recruiting, with more weight in Phase 1-2.

Corpus placement: #953 of 28,707 conditions by registered trial count.

18 US clinical trials · 3 currently recruiting · #953 of 28,707 conditions by registered trial count

Anemia, Sickle Cell: 18 US clinical trials tracked, 3 recruiting.

Anemia, Sickle Cell is the subject of 18 registered US clinical trials on ClinicalTrials.gov, 3 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is Duke University, running 2 of these trials.

Enrollment posture brief

Registry condition anemia-sickle-cell

OPEN 3 | RECR 17% | LATE 1 | EARLY 7 | RANK #953 | SPON 2

Nearest open-share peer: Acute Renal Failure (17% recruiting · 6 trials)

Atrial Fibrillation66.7%Arrhythmias, Cardiac27.8%Anemia, Sickle Cell (this)17%Androgenetic Alopecia16.7%Acquired Immunodeficiency Sy5.6%
Open-enrollment share among volume-matched conditions near Anemia, Sickle Cell

Anemia, Sickle Cell lists 3 open slots (17% of 18 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Anemia, Sickle Cell on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Anemia, Sickle Cell is recruiting below its size-band peers.

    3 of 18 indexed trials (16.7%) are open to enrollment, against a 46.5% average across 27,806 conditions with fewer than 20 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. Sponsorship of Anemia, Sickle Cell trials is spread across many organizations.

    Duke University accounts for 2 of 18 trials (11.1%). 16 distinct sponsors appear on at least one study for this condition label.

  3. Typical Anemia, Sickle Cell enrolment sits around 102 participants.

    Median target enrolment is 102 among the 18 trials that report a genuine target (sentinel values excluded). 9 of those (50%) plan for fewer than 100 participants.

  4. Anemia, Sickle Cell research is mostly interventional.

    15 interventional and 3 observational studies make up this index (83.3% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 14Phase 23Phase 41

Open and recent trials

18 total, page 1 of 1

RECRUITING Phase 2 310 participants

A Socio-ecological Approach for Improving Self-management in Adolescents With SCD

Children's Hospital Medical Center, Cincinnati

NCT06290401

RECRUITING Phase 1 184 participants

A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease

Bristol-Myers Squibb

NCT06481306

RECRUITING NA 120 participants

Metabolic and Hemodynamic Reserve in Pediatric SCA

Washington University School of Medicine

NCT04406818

ACTIVE NOT RECRUITING NA 150 participants

Therapeutic Response Evaluation and Adherence Trial (TREAT)

Children's Hospital Medical Center, Cincinnati

NCT02286154

ACTIVE NOT RECRUITING 102 participants

Epidemiology of Silent and Overt Strokes in Sickle Cell Disease

Vanderbilt University Medical Center

NCT03376893

ACTIVE NOT RECRUITING NA 24 participants

Telemedicine for Children With Sickle Cell Disease

Indiana University

NCT05087303

ACTIVE NOT RECRUITING Phase 1 3 participants

A Blood Stem Cell Transplant for Sickle Cell Disease

City of Hope Medical Center

NCT03249831

COMPLETED NA 279 participants

Effectiveness of a Computerized Tool (PAINRelieveIt) to Help Manage Pain Related to Sickle Cell Disease

University of Illinois at Chicago

NCT00600665

COMPLETED NA 279 participants

Implementing an Individualized Pain Plan (IPP) for ED Treatment of VOE's in Sickle Cell Disease

Duke University

NCT04584528

COMPLETED Phase 2 150 participants

Nitric Oxide Inhalation to Treat Sickle Cell Pain Crises

Mallinckrodt

NCT00094887

COMPLETED Phase 4 124 participants

Intranasal Fentanyl for Initial Treatment of a Vaso-occlusive Crisis

Montefiore Medical Center

NCT01482091

COMPLETED NA 91 participants

Feasibility and Efficacy of a Home-based, Computerized Cognitive Training Program in Pediatric Sickle Cell Disease

Steven J. Hardy

NCT02857023

COMPLETED NA 60 participants

MBSR for Pain Catastrophizing in SCD

Duke University

NCT02394587

COMPLETED 44 participants

A Self-Management Intervention for Youth With Sickle Cell Disease and Their Families: Phase I

Medical University of South Carolina

NCT03069430

COMPLETED Phase 1 36 participants

Examining Cognitive Function and Brain Abnormalities in Adults With Sickle Cell Disease - Pilot Intervention Study

UCSF Benioff Children's Hospital Oakland

NCT00850018

COMPLETED Phase 2 30 participants

Cord Blood Transplantation for Sickle Cell Anemia and Thalassemia

National Heart, Lung, and Blood Institute (NHLBI)

NCT00029380

COMPLETED Phase 1 17 participants

Hydroxyurea and EPO in Sickle Cell Disease

Julia Xu

NCT05451940

COMPLETED 5 participants

Quality of Life of Children With Sickle Cell Disease Who Are Getting Chronic Transfusions With a Lifeport

Children's Mercy Hospital Kansas City

NCT00246077

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 3
Phase 4 1

Named interventions

Most-linked intervention names on Anemia, Sickle Cell records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Hydroxyurea Drug
2 trials
Placebo Drug
2 trials
Cyclophosphamide Drug
2 trials
SELFY (Self Management for Youth with SCD) Behavioral
1 trials
Mindfulness-based Stress Reduction Behavioral
1 trials
Electronic Health Record (EHR) Embedded Individualized Pain Plan (IPP) Other
1 trials
PAINConsultN Behavioral
1 trials
PAINUCope Behavioral
1 trials

US sites by state

Facility locations filed on Anemia, Sickle Cell trials. A trial with sites in several states counts in each.

California 6 trials
Pennsylvania 5 trials
Missouri 5 trials
Ohio 4 trials
North Carolina 4 trials
Illinois 4 trials
Georgia 4 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Anemia, Sickle Cell page

18 registered trials, 3 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

  • 3 Anemia, Sickle Cell trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
  • Duke University sponsors the most Anemia, Sickle Cell trials on record, review their full trial history before evaluating a specific study. See Duke University's trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Anemia, Sickle Cell condition card totals 18 registered trials; most-linked intervention Hydroxyurea; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.