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2026 data Public-data reference. official source

Metastatic Prostate Cancer

Open-data reference.

42 US clinical trials · 22 currently recruiting

Active & Recent Trials

RECRUITING 1,000 participants

Collection of Blood From Patients With Prostate Cancer

National Cancer Institute (NCI)

NCT00923221

RECRUITING Phase 2 464 participants

Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer

VA Office of Research and Development

NCT04787744

RECRUITING NA 256 participants

Physician- and Patient-based Barriers to NGS Testing

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT07209176

RECRUITING Phase 1 250 participants

Study of ORIC-944 in Patients With Metastatic Prostate Cancer

ORIC Pharmaceuticals

NCT05413421

RECRUITING Phase 1 210 participants

A Study Evaluating the Safety, Pharmacokinetics, and Activity of RO7656594 In Participants With Advanced or Metastatic Prostate Cancer

Genentech

NCT05800665

RECRUITING Phase 3 200 participants

Creatine Supplementation and Resistance Training to Preserve Muscle Mass and Attenuate Cancer Progression

University of Utah

NCT06112990

RECRUITING Phase 1 177 participants

Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer

AstraZeneca

NCT07181161

RECRUITING NA 80 participants

Debunking the Frailty-sarcopenIa-ADT Axis in mEtastatic Prostate canceR With multiComponent Exercise: The FIERCE Trial

Dana-Farber Cancer Institute

NCT06040125

RECRUITING NA 74 participants

Impact of Multimodal Telerehabilitation in Rural Patients With Metastatic Prostate Cancer

University of Utah

NCT07032584

RECRUITING Phase 1 71 participants

A Study of Evofosfamide in Combination with Zalifrelimab and Balstilimab

ImmunoGenesis

NCT06782555

RECRUITING Phase 1 60 participants

Study of AZD0754 in Participants With Metastatic Prostate Cancer

AstraZeneca

NCT06267729

RECRUITING Phase 2 58 participants

Trial Targeting Gut Bacterial Androgen Production to Reverse Therapeutic Resistance to Abiraterone in Patients With Metastatic Prostate Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06616597

RECRUITING Phase 2 51 participants

High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers

VA Office of Research and Development

NCT05011383

RECRUITING Phase 2 44 participants

Cabazitaxel +/- Carboplatin vs 177Lu-PSMA-617 in Metastatic Castrate-resistant Prostate Cancer

Case Comprehensive Cancer Center

NCT06738303

RECRUITING Phase 1 37 participants

LuCarbo - a Study of 177Lu-PSMA-617 Plus Carboplatin in Metastatic Castrate-resistant Prostate Cancer

Dana-Farber Cancer Institute

NCT06303713

RECRUITING Phase 2 32 participants

A Study of Tarlatamab for People With Prostate Cancer

Memorial Sloan Kettering Cancer Center

NCT07111507

RECRUITING Phase 1 30 participants

Pilot Study for Detection of PSMA-Low CRPC-NE Tumors With Fluciclovine PET/CT

Brigham and Women's Hospital

NCT06062745

RECRUITING Phase 1 30 participants

177Lu-PSMA-617 With Liver Directed Therapy in Metastatic Castration Resistant Prostate Cancer

University of California, San Francis

NCT07145177

RECRUITING Phase 2 26 participants

Study of Sipuleucel-T With or Without Continuing New Hormonal Agents in Metastatic Prostate Cancer

H. Lee Moffitt Cancer Center and Research Institute

NCT05751941

RECRUITING NA 24 participants

Remotely Monitored Exercise Interventions in Patients with MCSPC Undergoing ADT (Prostate 006)

Paul Viscuse

NCT06429813

RECRUITING Phase 4 15 participants

18F-Fluciclovine PET/CT Impact on Predicting Clinical Outcome of 177Lu-PSMA-617 Therapy in Patients With Prostate Cancer

VA Greater Los Angeles Healthcare System

NCT06706921

RECRUITING NA 10 participants

7-Days Water-Only Fasting Trial in Prostate Cancer

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT06826924

ACTIVE NOT RECRUITING NA 866 participants

INTense ExeRcise for SurviVAL Among Men with Metastatic Prostate Cancer (INTERVAL - GAP4)

Movember Foundation

NCT02730338

ACTIVE NOT RECRUITING Phase 1 733 participants

Safety, PK and Efficacy of ONC-392 in Monotherapy and in Combination of Anti-PD-1 in Advanced Solid Tumors and NSCLC

OncoC4

NCT04140526

ACTIVE NOT RECRUITING Phase 3 575 participants

Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC

Exelixis

NCT04446117

ACTIVE NOT RECRUITING Phase 1 183 participants

ARX517/JNJ-95298177 as Monotherapy or Combination Therapy in Subjects With Metastatic Prostate Cancer

Janssen Research & Development

NCT04662580

ACTIVE NOT RECRUITING Phase 1 174 participants

Study of AZD5305 When Given in Combination With New Hormonal Agents in Patients With Metastatic Prostate Cancer

AstraZeneca

NCT05367440

ACTIVE NOT RECRUITING Phase 1 125 participants

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

Sapience Therapeutics

NCT04478279

ACTIVE NOT RECRUITING Phase 2 111 participants

Androgen Receptor Directed Therapy on Cognitive Function in Patients Treated With Darolutamide or Enzalutamide

Alliance Foundation Trials

NCT04335682

ACTIVE NOT RECRUITING Phase 2 96 participants

18F-DCFPyL PSMA- Versus 18F-NaF-PET Imaging for Detection of Metastatic Prostate Cancer

National Cancer Institute (NCI)

NCT03173924

ACTIVE NOT RECRUITING 58 participants

Prostate-Specific Membrane Antigen (PSMA) PET Scans in People Prostate Cancer

Memorial Sloan Kettering Cancer Center

NCT04030338

ACTIVE NOT RECRUITING Phase 2 41 participants

A Study of Chemoimmunotherapy for the Treatment of Men With Neuroendocrine or Aggressive Variant Metastatic Prostate Cancer

Andrew J. Armstrong, MD

NCT04709276

ACTIVE NOT RECRUITING Phase 1 35 participants

Phase Ia/Ib Talazoparib + Tazemetostat for mCRPC

Dana-Farber Cancer Institute

NCT04846478

ACTIVE NOT RECRUITING Phase 2 28 participants

Study of Abiraterone Acetate or Enzalutamide, Atezolizumab, GnRH Analog and Radiation Therapy in Men With Newly Diagnosed Hormone-sensitive Prostate Cancer

Memorial Sloan Kettering Cancer Center

NCT04262154

ACTIVE NOT RECRUITING Phase 4 20 participants

PSMAtrack-tracking Changes in PSMA-PET During Initial Therapy for Metastatic Hormone-sensitive Prostate Cancer

Brigham and Women's Hospital

NCT06479187

ACTIVE NOT RECRUITING Phase 2 11 participants

Prostate Cancer Monitoring Using [18F]DCFPyL and Blood Based Biomarkers

Columbia University

NCT03585114

ACTIVE NOT RECRUITING Phase 1 9 participants

Neo-DAB: Darolutamide and Abemaciclib in Prostate Cancer

Praful Ravi, MB BCHir, MRCP

NCT05617885

COMPLETED Phase 3 1,101 participants

Ipatasertib Plus Abiraterone Plus Prednisone/Prednisolone, Relative to Placebo Plus Abiraterone Plus Prednisone/Prednisolone in Adult Male Patients With Metastatic Castrate-Resistant Prostate Cancer

Hoffmann-La Roche

NCT03072238

COMPLETED Phase 2 120 participants

I-131-1095 Radioligand Plus Enzalutamide vs Enzalutamide for mCRPC That Progressed During Abiraterone (ARROW).

Progenics Pharmaceuticals

NCT03939689

COMPLETED Phase 3 107 participants

TAVT-45 (Abiraterone Acetate) Granules in Patients With Prostate Cancer

Tavanta Therapeutics

NCT04887506

COMPLETED Phase 2 29 participants

Non-Randomized Trial Assessing Pain Efficacy With Radium-223 in Symptomatic Metastatic Castration-Resistant Prostate Cancer

Memorial Sloan Kettering Cancer Center

NCT02278055

COMPLETED Phase 2 26 participants

Pembrolizumab in Metastatic Castration Resistant Prostate Cancer (mCRPC) With or Without DNA Damage Repair Defects

University of California, San Francis

NCT03248570

Phase Distribution

PhaseTrial count
Early Phase 1 14
Phase 2 14
Phase 3 4
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Prostate Cancer Trial Landscape

ClinicalTrials.gov lists 42 US studies indexed under Metastatic Prostate Cancer, and 22 of those are currently open to recruitment — roughly 52% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Metastatic Prostate Cancer shows 6 late-stage studies (Phase 3 and Phase 4 combined) alongside 28 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Metastatic Prostate Cancer is led by Memorial Sloan Kettering Cancer Center with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 42 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Prostate Cancer?

PlainTrial tracks 42 US clinical trials for Metastatic Prostate Cancer, of which 22 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Prostate Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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