Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

Study of ORIC-944 in Patients With Metastatic Prostate Cancer

NCT05413421 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to establish the safety and preliminary antitumor activity of ORIC-944 as a single agent and in combinations with ARPIs in patients with metastatic prostate cancer.

Conditions Studied

Interventions

  • DRUG ORIC-944
  • DRUG Abiraterone acetate (Zytiga®) 250 mg or 500 mg tablets
  • DRUG Apalutamide (Erleada™) 60 mg or 240 mg tablets
  • DRUG Darolutamide (Nubeqa®) 300 mg tablets
  • DRUG Enzalutamide (Xtandi®) 40 mg capsules or 40 mg and 80 mg tablets

Study Locations (20)

Illinois

  • Illinois Cancer Specialists — Arlington Heights
  • Comprehensive Urologic Care — Lake Barrington

Maryland

  • Marlene & Stewart Greenebaum Comprehensive Cancer Center, University of Maryland — Baltimore
  • Maryland Oncology Hematology — Silver Spring

Pennsylvania

  • MidLantic Urology — Bala-Cynwyd
  • Keystone Urology Specialists — Lancaster

Texas

  • Amarillo Urology Research — Amarillo
  • Urology Clinics of North Texas — Dallas

Virginia

  • Virginia Oncology Associates — Fairfax
  • Virginia Cancer Specialists — Norfolk

Colorado

  • Rocky Mountain Cancer Center — Colorado Springs

Florida

  • South Florida Oncology and Hematology — Plantation

Indiana

  • First Urology — Jeffersonville

Trial Details

FieldValue
Enrollment Target 250 participants
Start Date 2022-06-01
Est. Completion 2026-09
Phase Phase 1

Sponsor

ORIC Pharmaceuticals

3 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05413421

The ClinicalTrials.gov registry entry for NCT05413421 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 250 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is ORIC Pharmaceuticals, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Metastatic Prostate Cancer appearing as the primary indexed condition, and to 5 interventions — of which ORIC-944 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05413421 reports 20 study locations spanning 15 distinct geographic areas — top geographies include Illinois, Maryland, Pennsylvania. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05413421 about?

NCT05413421 is a clinical study titled "Study of ORIC-944 in Patients With Metastatic Prostate Cancer". The purpose of this study is to establish the safety and preliminary antitumor activity of ORIC-944 as a single agent and in combinations with ARPIs in patients with metastatic prostate cancer.

What is the current status of trial NCT05413421?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 250 participants. The study started on 2022-06-01. Estimated completion is 2026-09.

What conditions does trial NCT05413421 study?

This clinical trial studies the following conditions: Metastatic Prostate Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05413421?

The interventions under investigation include: ORIC-944 (DRUG), Abiraterone acetate (Zytiga®) 250 mg or 500 mg tablets (DRUG), Apalutamide (Erleada™) 60 mg or 240 mg tablets (DRUG), Darolutamide (Nubeqa®) 300 mg tablets (DRUG), Enzalutamide (Xtandi®) 40 mg capsules or 40 mg and 80 mg tablets (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05413421?

This trial is sponsored by ORIC Pharmaceuticals, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05413421 being conducted?

This trial has 20 study locations across Colorado, Florida, Illinois, Indiana, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial