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ClinicalTrials.gov 11 recruiting now official registry

End-Stage Kidney Disease clinical trials

11 of 21 indexed End-Stage Kidney Disease trials are currently recruiting.

21 US clinical trials · 11 currently recruiting

End-Stage Kidney Disease is the subject of 21 registered US clinical trials on ClinicalTrials.gov, 11 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is Diality, running 2 of these trials.

The research picture

End-Stage Kidney Disease has 21 registered US clinical trials, 11 of them open to new participants right now, about 52% of the total.

11
recruiting participants now
52%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
2
top sponsor: Diality
Phase 14Phase 22Phase 32

Active & Recent Trials

21 total, page 1 of 1

RECRUITING Phase 3 2,540 participants

CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes

VA Office of Research and Development

NCT05931276

RECRUITING NA 2,400 participants

Symptom Monitoring in Hemodialysis

University of Pennsylvania

NCT05738330

RECRUITING Phase 2 2,310 participants

Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis

CSL Behring

NCT05485961

RECRUITING NA 350 participants

Incremental Hemodialysis: The TwoPlus Trial

Wake Forest University Health Sciences

NCT05828823

RECRUITING 200 participants

Duke APOL1 Research Biorepository

Duke University

NCT04160507

RECRUITING NA 125 participants

Pain Reduction Using NEurostimulation Study

Weill Medical College of Cornell University

NCT05311956

RECRUITING NA 100 participants

Shared Decision Making for Kidney Transplant Candidates to Plan for an Organ Offer Decision

Hennepin Healthcare Research Institute

NCT05879302

RECRUITING NA 50 participants

Moda-flx Hemodialysis System™ Under Professional Care Settings by Trained Individuals and At Home by Participants

Diality

NCT06613568

RECRUITING Phase 1 28 participants

A Study of Eloralintide (LY3841136) in Participants With Renal Impairment and in Participants With Normal Renal Function

Eli Lilly and Company

NCT07426380

RECRUITING NA 20 participants

Staged Kidney Transplantation During Combined Heart/Kidney Transplantation

Cedars-Sinai Medical Center

NCT06877169

RECRUITING Phase 1 10 participants

Delayed Immunological Tolerance in Patients With Well-functioning Pre-existing HLA-matched Kidney Transplants

University of California, Los Angeles

NCT05525507

ACTIVE NOT RECRUITING NA 103 participants

The Arteriovenous Vascular (AV) ACCESS Trial

Wake Forest University Health Sciences

NCT04646226

ACTIVE NOT RECRUITING NA 61 participants

Virtual Reality in Hemodialysis to Improve Psychological Well-being

University of Illinois at Urbana-Champaign

NCT05642364

ACTIVE NOT RECRUITING Phase 1 16 participants

Immunological Tolerance in Patients With Mismatched Kidney Transplants

University of California, Los Angeles

NCT05806749

COMPLETED Phase 2 506 participants

Global Study of MK-2060 (Anti-Factor XI Monoclonal Antibody) in Participants With End Stage Renal Disease Receiving Hemodialysis (FXI Hemodialysis Study) (MK-2060-007)

Merck Sharp & Dohme

NCT05027074

COMPLETED Phase 3 269 participants

Trial to Evaluate the Sirolimus-Eluting Collagen Implant on AV Fistula Outcomes

Vascular Therapies

NCT02513303

COMPLETED NA 103 participants

Percutaneous Less Invasive AV Fistula for Vascular Access in ESRD

Medtronic Endovascular

NCT02363972

COMPLETED Phase 1 62 participants

Safety, Tolerability, and Feasibility of Empagliflozin Therapy in Dialysis-dependent ESKD

University of Utah

NCT05614115

COMPLETED NA 40 participants

Continuous Glucose Monitoring in Patients With End-Stage Kidney Disease and Burnt-Out Diabetes

Emory University

NCT05741489

COMPLETED NA 12 participants

First Evaluation of the Moda-Flx Hemodialysis System™ in Real World Clinical Settings

Diality

NCT06581393

COMPLETED 10 participants

Blood Volume Analysis and Related Outcomes in Hemodialysis

VA New York Harbor Healthcare System

NCT01679249

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 2
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the End-Stage Kidney Disease Trial Landscape

21 indexed End-Stage Kidney Disease studies · 11 recruiting (52%).

Phase mix: 2 late (III/IV) vs 6 early (I/II).

Top sponsor: Diality (2 trials), 9 others listed. 21 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for End-Stage Kidney Disease?

PlainTrial tracks 21 US clinical trials for End-Stage Kidney Disease, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for End-Stage Kidney Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.