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ClinicalTrials.gov 46 recruiting now official registry

Metastatic Malignant Solid Neoplasm clinical trials

46 of 93 indexed Metastatic Malignant Solid Neoplasm trials are currently recruiting.

93 US clinical trials · 46 currently recruiting

Metastatic Malignant Solid Neoplasm is the subject of 93 registered US clinical trials on ClinicalTrials.gov, 46 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 76 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 38 of these trials.

The research picture

Metastatic Malignant Solid Neoplasm has 93 registered US clinical trials, 46 of them open to new participants right now, about 49% of the total.

46
recruiting participants now
49%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
38
top sponsor: National Cancer Institute (NCI)
Phase 154Phase 222Phase 32

Active & Recent Trials

93 total, page 2 of 2

ACTIVE NOT RECRUITING NA 208 participants

Learning Collaborative Versus Technical Assistance in Delivering a Palliative Care Program to Patients With Advanced Cancer and Their Caregivers

University of Rochester NCORP Research Base

NCT04062552

ACTIVE NOT RECRUITING 192 participants

Frequency of Cachexia in Ambulatory Cancer Patients and Psychological Burden in Patients and Their Primary Caregivers

M.D. Anderson Cancer Center

NCT04090619

ACTIVE NOT RECRUITING Phase 1 173 participants

Avelumab, Utomilumab, Anti-OX40 Antibody PF-04518600, and Radiation Therapy in Treating Patients With Advanced Malignancies

M.D. Anderson Cancer Center

NCT03217747

ACTIVE NOT RECRUITING Phase 2 157 participants

Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic

M.D. Anderson Cancer Center

NCT02721732

ACTIVE NOT RECRUITING Phase 2 129 participants

Anamorelin Hydrochloride, Physical Activity, and Nutritional Counseling in Decreasing Cancer-Related Fatigue in Patients With Incurable Metastatic or Recurrent Solid Tumors

M.D. Anderson Cancer Center

NCT03035409

ACTIVE NOT RECRUITING Phase 2 110 participants

Neuropsychological Care for Maintaining Quality of Life After Radiation Therapy in Patients With Brain Metastases

Ohio State University Comprehensive Cancer Center

NCT05503251

ACTIVE NOT RECRUITING Phase 1 103 participants

Testing the Combination of New Anti-cancer Drug Peposertib With Avelumab and Radiation Therapy for Advanced/Metastatic Solid Tumors and Hepatobiliary Malignancies

National Cancer Institute (NCI)

NCT04068194

ACTIVE NOT RECRUITING Phase 2 100 participants

Open Labeled Placebo in Reducing Cancer Related Fatigue in Patients With Advanced Cancer

M.D. Anderson Cancer Center

NCT03927885

ACTIVE NOT RECRUITING Phase 2 99 participants

Physical Activity With or Without Dexamethasone in Reducing Cancer-Related Fatigue in Patients With Locally Advanced, Metastatic, or Recurrent Cancer

M.D. Anderson Cancer Center

NCT03583255

ACTIVE NOT RECRUITING Phase 1 96 participants

Trametinib and Navitoclax in Treating Patients With Advanced or Metastatic Solid Tumors

National Cancer Institute (NCI)

NCT02079740

ACTIVE NOT RECRUITING Phase 1 94 participants

Veliparib, Paclitaxel, and Carboplatin in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery and Liver or Kidney Dysfunction

National Cancer Institute (NCI)

NCT01366144

ACTIVE NOT RECRUITING Phase 1 93 participants

Neratinib and Everolimus, Palbociclib, or Trametinib in Treating Participants With Refractory and Advanced or Metastatic Solid Tumors With EGFR Mutation/Amplification, HER2 Mutation/Amplification, or HER3/4 Mutation or KRAS Mutation

M.D. Anderson Cancer Center

NCT03065387

ACTIVE NOT RECRUITING Phase 1 88 participants

Veliparib and Topotecan Hydrochloride in Treating Patients With Solid Tumors, Relapsed or Refractory Ovarian Cancer, or Primary Peritoneal Cancer

National Cancer Institute (NCI)

NCT01012817

ACTIVE NOT RECRUITING Phase 2 87 participants

Cement Augmentation in Preventing Vertebral Body Compression Fracture Following Spine Stereotactic Radiosurgery in Patients With Solid Tumors and Spinal Metastases

M.D. Anderson Cancer Center

NCT02387905

ACTIVE NOT RECRUITING Phase 1 66 participants

M6620 and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT02595931

ACTIVE NOT RECRUITING Phase 1 65 participants

DS3201 and Ipilimumab for the Treatment of Metastatic Prostate, Urothelial and Renal Cell Cancers

M.D. Anderson Cancer Center

NCT04388852

ACTIVE NOT RECRUITING Phase 1 64 participants

Testing the Combination of Copanlisib, Nivolumab and Ipilimumab in Patients With Advanced Cancer and Lymphoma

National Cancer Institute (NCI)

NCT03502733

ACTIVE NOT RECRUITING Phase 1 62 participants

Testing the Biological Effects of DS-8201a on Patients With Advanced Cancer

National Cancer Institute (NCI)

NCT04294628

ACTIVE NOT RECRUITING Phase 2 60 participants

Testing AZD1775 in Advanced Solid Tumors That Have a Mutation Called SETD2

National Cancer Institute (NCI)

NCT03284385

ACTIVE NOT RECRUITING Phase 1 59 participants

Testing the PD-1 Antibody, MK3475, Given With Ziv-aflibercept in Patients With Advanced Cancer

National Cancer Institute (NCI)

NCT02298959

ACTIVE NOT RECRUITING Phase 1 54 participants

Testing the Addition of an Anti-cancer Drug, Copanlisib, to the Usual Immunotherapy (Nivolumab With or Without Ipilimumab) in Patients With Advanced Solid Cancers That Have Changes in the Following Genes: PIK3CA and PTEN

National Cancer Institute (NCI)

NCT04317105

ACTIVE NOT RECRUITING Phase 2 54 participants

Testing Whether Cancers With Specific Mutations Respond Better to Glutaminase Inhibitor, Telaglenastat Hydrochloride, Anti-Cancer Treatment, BeGIN Study

National Cancer Institute (NCI)

NCT03872427

ACTIVE NOT RECRUITING Phase 1 40 participants

Atezolizumab in Treating Patients With Cancer Following Adoptive Cell Transfer

National Cancer Institute (NCI)

NCT02862275

ACTIVE NOT RECRUITING Phase 2 40 participants

Testing the Use of Nilotinib and Paclitaxel as a Treatment for Patients With Prior Taxane Treatment, A ComboMATCH Treatment Trial

National Cancer Institute (NCI)

NCT05554341

ACTIVE NOT RECRUITING Phase 1 39 participants

Testing the Combination of the Anti-cancer Drugs Copanlisib, Olaparib, and MEDI4736 (Durvalumab) in Patients With Advanced Solid Tumors With Selected Mutations

National Cancer Institute (NCI)

NCT03842228

ACTIVE NOT RECRUITING Phase 1 37 participants

Ceritinib and Everolimus in Treating Patients With Locally Advanced or Metastatic Solid Tumors or Stage IIIB-IV Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT02321501

ACTIVE NOT RECRUITING Phase 1 36 participants

Pembrolizumab and Recombinant Interleukin-12 in Treating Patients With Solid Tumors

National Cancer Institute (NCI)

NCT03030378

ACTIVE NOT RECRUITING Phase 1 33 participants

Vemurafenib, Cetuximab, and Irinotecan Hydrochloride in Treating Patients With Solid Tumors That Are Metastatic or That Cannot Be Removed by Surgery

M.D. Anderson Cancer Center

NCT01787500

ACTIVE NOT RECRUITING Phase 1 28 participants

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to Usual Chemotherapy for Advanced Stage Solid Tumors, With a Specific Focus on Patients With Small Cell Lung Cancer, Poorly Differentiated Neuroendocrine Cancer, and Pancreatic Cancer

National Cancer Institute (NCI)

NCT04514497

ACTIVE NOT RECRUITING Early Phase 1 26 participants

Radiosurgery Before Surgery for the Treatment of Brain Metastases

Emory University

NCT04895592

ACTIVE NOT RECRUITING Phase 1 23 participants

Avelumab and M6620 for the Treatment of DDR Deficient Metastatic or Unresectable Solid Tumors

M.D. Anderson Cancer Center

NCT04266912

ACTIVE NOT RECRUITING Phase 1 18 participants

Niraparib and TSR-042 for the Treatment of BRCA-Mutated Unresectable or Metastatic Breast, Pancreas, Ovary, Fallopian Tube, or Primary Peritoneal Cancer

University of Washington

NCT04673448

ACTIVE NOT RECRUITING Phase 2 16 participants

Nivolumab for the Treatment of Metastatic or Unresectable Solid Tumors With ARID1A Mutation and CXCL13 Expression

M.D. Anderson Cancer Center

NCT04957615

ACTIVE NOT RECRUITING Phase 1 13 participants

Testing the Sequential Combination of the Anti-cancer Drugs Olaparib Followed by Adavosertib (AZD1775) in Patients With Advanced Solid Tumors With Selected Mutations and PARP Resistance, STAR Study

National Cancer Institute (NCI)

NCT04197713

COMPLETED 223 participants

Distress Associated with Coronavirus Disease 2019 and Telehealth on Supportive Care Patients with Advanced Cancer

M.D. Anderson Cancer Center

NCT05058339

COMPLETED Phase 1 83 participants

Sapanisertib and Ziv-Aflibercept in Treating Patients With Recurrent Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT02159989

COMPLETED Phase 1 51 participants

BMS-986156, Ipilimumab, and Nivolumab With or Without Stereotactic Body Radiation Therapy in Treating Patients With Advanced or Metastatic Lung/Chest or Liver Cancers

M.D. Anderson Cancer Center

NCT04021043

COMPLETED Phase 1 46 participants

Trametinib in Treating Patients With Advanced Cancer With or Without Hepatic Dysfunction

National Cancer Institute (NCI)

NCT02070549

COMPLETED Phase 1 43 participants

Ribociclib and Gemcitabine Hydrochloride in Treating Patients With Advanced or Metastatic Solid Tumors

Mayo Clinic

NCT03237390

COMPLETED Phase 1 36 participants

Cabozantinib S-Malate in Treating Patients With Advanced Solid Tumors and Human Immunodeficiency Virus

National Cancer Institute (NCI)

NCT01822522

COMPLETED Phase 1 35 participants

Abexinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumor Malignancies

Rahul Aggarwal

NCT03590054

COMPLETED Phase 1 28 participants

Olaparib and Onalespib in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery or Recurrent Ovarian, Fallopian Tube, Primary Peritoneal, or Triple-Negative Breast Cancer

National Cancer Institute (NCI)

NCT02898207

COMPLETED Phase 1 12 participants

SD-101 and BMS-986178 in Treating Patients With Advanced or Metastatic Solid Malignancies

Ronald Levy

NCT03831295

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Phase Distribution

PhaseTrial count
Phase 1 54
Phase 2 22
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Malignant Solid Neoplasm Trial Landscape

93 indexed Metastatic Malignant Solid Neoplasm studies · 46 recruiting (49%).

Phase mix: 2 late (III/IV) vs 76 early (I/II).

Top sponsor: National Cancer Institute (NCI) (38 trials), 9 others listed. 43 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Malignant Solid Neoplasm?

PlainTrial tracks 93 US clinical trials for Metastatic Malignant Solid Neoplasm, of which 46 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Malignant Solid Neoplasm?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.