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ClinicalTrials.gov 46 recruiting now official registry

Metastatic Malignant Solid Neoplasm clinical trials

46 of 93 indexed Metastatic Malignant Solid Neoplasm trials are currently recruiting.

93 US clinical trials · 46 currently recruiting

Metastatic Malignant Solid Neoplasm is the subject of 93 registered US clinical trials on ClinicalTrials.gov, 46 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 76 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 38 of these trials.

The research picture

Metastatic Malignant Solid Neoplasm has 93 registered US clinical trials, 46 of them open to new participants right now, about 49% of the total.

46
recruiting participants now
49%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
38
top sponsor: National Cancer Institute (NCI)
Phase 154Phase 222Phase 32

Active & Recent Trials

93 total, page 1 of 2

RECRUITING 5,000 participants

Collection and Storage of Tissue and Blood Samples From Patients With Cancer

National Cancer Institute LAO

NCT02474160

RECRUITING Phase 2 2,900 participants

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

National Cancer Institute (NCI)

NCT05564377

RECRUITING 500 participants

Evaluation of Anti-PD-1 Therapy by Monitoring T Cell Responses in Melanoma, Lung and Other Cancer Types

Mayo Clinic

NCT06075524

RECRUITING Phase 2 500 participants

Personalized Antibody-Drug Conjugate Therapy Based on RNA and Protein Testing for the Treatment of Advanced or Metastatic Solid Tumors (The ADC MATCH Screening and Treatment Trial)

National Cancer Institute (NCI)

NCT06311214

RECRUITING NA 400 participants

Group Cognitive Behavior Sessions (CBCSM) to Decrease Distress in Cancer Patients

Mayo Clinic

NCT06015932

RECRUITING Phase 3 280 participants

Comparing Radiation Therapy to Usual Care for Patients With High-Risk Bone Asymptomatic Metastases, PREEMPT Trial

NRG Oncology

NCT06745024

RECRUITING Phase 3 269 participants

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

NRG Oncology

NCT06500455

RECRUITING Phase 2 230 participants

Salvage Radiation Therapy in Treating Patients With Metastatic Cancer That Has Progressed After Systemic Immunotherapy

M.D. Anderson Cancer Center

NCT02710253

RECRUITING NA 120 participants

Parenting Support Intervention for Families Coping With Metastatic or Locally Recurrent Solid Tumor Diagnosis

M.D. Anderson Cancer Center

NCT05059678

RECRUITING Phase 2 115 participants

Durvalumab in Combination With Chemotherapy in Treating Patients With Advanced Solid Tumors, DURVA+ Trial

National Cancer Institute (NCI)

NCT03907475

RECRUITING Phase 1 111 participants

Talazoparib and Palbociclib, Axitinib, or Crizotinib for the Treatment of Advanced or Metastatic Solid Tumors, TalaCom Trial

M.D. Anderson Cancer Center

NCT04693468

RECRUITING Phase 2 105 participants

Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial)

National Cancer Institute (NCI)

NCT05638295

RECRUITING Phase 1 95 participants

Studying TAK-243 in Patients With Advanced Cancer

National Cancer Institute (NCI)

NCT06223542

RECRUITING NA 90 participants

Neurocognition in Patients With Multiple Brain Metastases Treated With Radiosurgery

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT03184038

RECRUITING Phase 2 89 participants

Ceralasertib (AZD6738) Alone and in Combination With Olaparib or Durvalumab in Patients With Solid Tumors

Rahul Aggarwal

NCT03682289

RECRUITING Phase 2 88 participants

Testing the Combination of the Anti-cancer Drugs ZEN003694 (ZEN-3694) and Talazoparib in Patients With Advanced Solid Tumors, The ComBET Trial

National Cancer Institute (NCI)

NCT05327010

RECRUITING Phase 1 77 participants

A Cancer Vaccine (Labvax 3(22)-23) and GM-CSF Alone or in Combination With Pembrolizumab for the Treatment of Advanced Stage Adenocarcinoma

Tianhong Li

NCT05101356

RECRUITING Phase 2 69 participants

SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

Mayo Clinic

NCT05222620

RECRUITING Phase 1 66 participants

Testing the Combination of Two Anti-cancer Drugs, Peposertib (M3814) and Tuvusertib (M1774) for Advanced Solid Tumors

National Cancer Institute (NCI)

NCT05687136

RECRUITING Phase 2 64 participants

Pemetrexed Response in Relation to Tumor Alterations of Gene Status for the Treatment of Patients With Metastatic Urothelial Bladder Cancer and Other Solid Tumors

Northwestern University

NCT06630416

RECRUITING Phase 1 58 participants

Testing the Combination of the Anti-Cancer Drugs Temozolomide and M1774 to Evaluate Their Safety and Effectiveness

National Cancer Institute (NCI)

NCT05691491

RECRUITING Phase 1 56 participants

Imaging of Solid Tumors Using 18F-TRX

Rahul Aggarwal

NCT06942104

RECRUITING Phase 1 55 participants

Testing the Combination of DS-8201a and Olaparib in HER2-Expressing Cancers With Expansion in Patients With Platinum Resistant Ovarian Cancer

National Cancer Institute (NCI)

NCT04585958

RECRUITING Phase 1 52 participants

TR-002 for the Treatment of Advanced, Unresectable or Metastatic Solid Tumors and Unresectable or Metastatic, Refractory Pancreatic Adenocarcinoma

University of California, Davis

NCT07189195

RECRUITING 50 participants

Examining Blood and Tissue Samples to Identify Diagnostic Markers in Patients With Metastatic Cancer Undergoing Tumor Removal

Mayo Clinic

NCT05530759

RECRUITING Phase 2 50 participants

Avapritinib for the Treatment of CKIT or PDGFRA Mutation-Positive Locally Advanced or Metastatic Malignant Solid Tumors

M.D. Anderson Cancer Center

NCT04771520

RECRUITING Phase 1 49 participants

PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer

City of Hope Medical Center

NCT04329494

RECRUITING Phase 1 48 participants

Testing the Combination of the Anticancer Drugs Trastuzumab Deruxtecan (DS-8201a) and Azenosertib (ZN-c3) in Patients With Stomach or Other Solid Tumors

National Cancer Institute (NCI)

NCT06364410

RECRUITING Phase 1 45 participants

Testing the Safety and Efficacy of the Combination of Two Anti-cancer Drugs, ZEN003694 and Abemaciclib, for Adult and Pediatric Patients (12-17 Years) With Metastatic or Unresectable NUT Carcinoma, Breast Cancer and Other Solid Tumors

National Cancer Institute (NCI)

NCT05372640

RECRUITING Phase 1 43 participants

Studying the Safety and Determining the Optimal Dose of Novobiocin in Patients With Tumors That Have Alterations in DNA Repair Genes

National Cancer Institute (NCI)

NCT05687110

RECRUITING Phase 1 42 participants

MTI-301 for the Treatment of Metastatic or Unresectable and Refractory Solid Cancers

Mayo Clinic

NCT06911008

RECRUITING Phase 1 40 participants

Phase I/II Randomized Study of NBTXR3 Activated by Abscopal or RadScopal Radiation in Combination With Immunotherapy (Anti-PD-1/L-1) for Patients With Advanced Solid Malignancies

M.D. Anderson Cancer Center

NCT05039632

RECRUITING NA 40 participants

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

M.D. Anderson Cancer Center

NCT04693377

RECRUITING Phase 1 40 participants

Testing How the Body Responds to the Drug CX-5461 (Pidnarulex) in Patients With Metastatic Solid Cancers

National Cancer Institute (NCI)

NCT06606990

RECRUITING Phase 2 40 participants

Pembrolizumab in Treating Participants With Metastatic, Recurrent or Locally Advanced Cancer and Genomic Instability

Rutgers, The State University of New Jersey

NCT03428802

RECRUITING Phase 1 38 participants

Axatilimab in Combination With Retifanlimab and Paclitaxel for the Treatment of Patients With Advanced or Metastatic Solid Tumors

OHSU Knight Cancer Institute

NCT06320405

RECRUITING Phase 1 36 participants

Testing the Safety of the Combination of Anti-Cancer Drugs CX-5461 (Pidnarulex) and Trastuzumab Deruxtecan (T-DXd) for Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Solid Tumors and Breast Cancer

National Cancer Institute (NCI)

NCT07137416

RECRUITING Phase 1 35 participants

Testing How the Body Responds to the Drug CBX-12 in Patients With Advanced Solid Cancers

National Cancer Institute (NCI)

NCT05691517

RECRUITING Phase 1 30 participants

Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers

National Cancer Institute (NCI)

NCT05803382

RECRUITING Phase 1 24 participants

Biology-Guided Radiation Therapy for the Treatment of Patients With Bone Metastases

City of Hope Medical Center

NCT06549478

RECRUITING Phase 1 24 participants

Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity KRASG12V Mutation-Specific T Cell Receptors (FH-A11KRASG12V-TCR) in Treating Patients With Metastatic Solid Tumor Cancers With KRAS G12V Mutations

Fred Hutchinson Cancer Center

NCT06043713

RECRUITING NA 20 participants

Spatiotemporal Stereotactic Body Radiation Therapy for the Treatment of Patients With Polymetastatic Solid Tumors

City of Hope Medical Center

NCT05733949

RECRUITING Phase 1 18 participants

Gene Modified Immune Cells After Conditioning Regimen for the Treatment of Stage IIIC or IV Melanoma or Metastatic Solid Tumors

Anusha Kalbasi

NCT04119024

RECRUITING Phase 2 13 participants

Larotrectinib for the Treatment of NTRK Amplification Positive, Locally Advanced or Metastatic Solid Tumors

M.D. Anderson Cancer Center

NCT04879121

RECRUITING Phase 1 10 participants

Study to Evaluate CD8 PET Imaging as a Marker of Immune Response to Stereotactic Body Radiation Therapy (ELIXR)

City of Hope Medical Center

NCT05371132

RECRUITING Early Phase 1 10 participants

Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases

Emory University

NCT06328686

ACTIVE NOT RECRUITING 1,877 participants

NCI COVID-19 in Cancer Patients, NCCAPS Study

National Cancer Institute (NCI)

NCT04387656

ACTIVE NOT RECRUITING NA 1,284 participants

Does the Use of a Genomic Tumor Board Increase the Number of Patients Who Receive Genome-Informed Treatment

SWOG Cancer Research Network

NCT05455606

ACTIVE NOT RECRUITING NA 331 participants

Financial Navigation Program to Improve Understanding and Management of Financial Aspects of Cancer Care for Patients and Their Spouses

SWOG Cancer Research Network

NCT04960787

ACTIVE NOT RECRUITING NA 243 participants

A Video Intervention to Improve Patient Understanding of Tumor Genomic Testing in Patients With Metastatic Cancer

Ohio State University Comprehensive Cancer Center

NCT05215769

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Phase Distribution

PhaseTrial count
Phase 1 54
Phase 2 22
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Malignant Solid Neoplasm Trial Landscape

93 indexed Metastatic Malignant Solid Neoplasm studies · 46 recruiting (49%).

Phase mix: 2 late (III/IV) vs 76 early (I/II).

Top sponsor: National Cancer Institute (NCI) (38 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Malignant Solid Neoplasm?

PlainTrial tracks 93 US clinical trials for Metastatic Malignant Solid Neoplasm, of which 46 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Malignant Solid Neoplasm?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.