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NCT04895592 · ClinicalTrials.gov registry record · Early Phase 1
Radiosurgery Before Surgery for the Treatment of Brain Metastases
A Early Phase 1 study of Metastatic Malignant Solid Neoplasm and Metastatic Malignant Neoplasm in the Brain, sponsored by Emory University.
- Active
- Registry status
- Early Phase 1
- Development phase
- 26
- Enrollment target
- 1
- Study location
NCT04895592: Active Early Phase 1 study of Metastatic Malignant Solid Neoplasm and Metastatic Malignant Neoplasm in the Brain, sponsored by Emory University.
NCT04895592 is a Early Phase 1 study of Metastatic Malignant Solid Neoplasm and Metastatic Malignant Neoplasm in the Brain that is active but no longer recruiting, run by Emory University. The registered enrollment target is 26 participants, below the 206-participant average among 92 other Metastatic Malignant Solid Neoplasm trials with a reported enrollment target (87% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04895592, a Early Phase 1 study of Metastatic Malignant Solid Neoplasm and Metastatic Malignant Neoplasm in the Brain, is active but no longer recruiting, sponsored by Emory University.
- ACTIVE NOT RECRUITING
- Registry status
- Early Phase 1
- Development phase
- 26 participants
- Enrollment target
- 1
- Study location
Study Summary
This early phase I trial identifies the side effects of stereotactic radiosurgery before surgery in treating patients with cancer that has spread to the brain (brain metastases). Radiation may stimulate an anti-tumor immune response. Giving stereotactic radiosurgery before surgery may reduce the risk of the cancer coming back after surgery.
Primary Outcome
Evaluated using Common Terminology Criteria for Adverse Events. Tolerability of this regimen will be defined as \< 33% of patients develop grade \> 3 at 4 months. Adverse events will be summarized descriptively using frequencies and percentages.
Conditions Studied
Interventions
- DRUG Dexamethasone
- RADIATION Stereotactic Radiosurgery
- PROCEDURE Resection
Study Locations (1)
Georgia
- Emory University Hospital/Winship Cancer Institute - Atlanta
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 26 participants |
| Start Date | 2021-07-20 |
| Est. Completion | 2027-02-19 |
| Phase | Early Phase 1 |
What the registry record for NCT04895592 still lists
NCT04895592 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 26 participants, a relatively small participant target, below the 206-participant average among 92 other Metastatic Malignant Solid Neoplasm trials with a reported enrollment target (87% lower).
The record links to 2 conditions, with Metastatic Malignant Solid Neoplasm appearing as the primary indexed condition, and to 3 interventions - of which Dexamethasone is the first listed.
NCT04895592 reports a single indexed study location in Georgia.
Frequently Asked Questions
What is clinical trial NCT04895592 about?
NCT04895592 is a clinical study titled "Radiosurgery Before Surgery for the Treatment of Brain Metastases". This early phase I trial identifies the side effects of stereotactic radiosurgery before surgery in treating patients with cancer that has spread to the brain (brain metastases). Radiation may stimulate an anti-tumor immune response. Giving stereotactic radiosurgery before surgery may reduce the ris...
What is the current status of trial NCT04895592?
This trial is currently active not recruiting. It is a Early Phase 1 study. The enrollment target is 26 participants. The study started on 2021-07-20. Estimated completion is 2027-02-19.
What conditions does trial NCT04895592 study?
This clinical trial studies the following conditions: Metastatic Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Brain.
What interventions are being tested in trial NCT04895592?
The interventions under investigation include: Dexamethasone (DRUG), Stereotactic Radiosurgery (RADIATION), Resection (PROCEDURE).
Who is sponsoring clinical trial NCT04895592?
This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04895592 being conducted?
This trial has 1 study location across Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04895592's enrollment target sits among peer trials
26 81st of 92 higher than 12 of 92 other Metastatic Malignant Solid Neoplasm trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Metastatic Malignant Solid Neoplasm trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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