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NCT03284385 · ClinicalTrials.gov registry record · Phase 2
Testing AZD1775 in Advanced Solid Tumors That Have a Mutation Called SETD2
A Phase 2 study of Metastatic Malignant Solid Neoplasm and Clear Cell Renal Cell Carcinoma, sponsored by National Cancer Institute (NCI).
- Active
- Registry status
- Phase 2
- Development phase
- 60
- Enrollment target
- 20
- Study locations
NCT03284385: Active Phase 2 study of Metastatic Malignant Solid Neoplasm and Clear Cell Renal Cell Carcinoma, sponsored by National Cancer Institute (NCI).
NCT03284385 is a Phase 2 study of Metastatic Malignant Solid Neoplasm and Clear Cell Renal Cell Carcinoma that is active but no longer recruiting, run by National Cancer Institute (NCI). The registered enrollment target is 60 participants, below the 206-participant average among 92 other Metastatic Malignant Solid Neoplasm trials with a reported enrollment target (71% lower). The trial reports 20 study locations across 8 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03284385, a Phase 2 study of Metastatic Malignant Solid Neoplasm and Clear Cell Renal Cell Carcinoma, is active but no longer recruiting, sponsored by National Cancer Institute (NCI).
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 60 participants
- Enrollment target
- 20
- Study locations
Study Summary
This phase II trial studies how well adavosertib works in treating patients with SETD2-deficient solid tumors that have spread to other places in the body (advanced/metastatic). Adavosertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Primary Outcome
Will be assessed by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria. The median duration of response will be descriptively reported using Kaplan-Meier product limit method along with 95% confidence interval. The objective response rate between cohorts will be compared using the chi-squared test.
Conditions Studied
Interventions
- DRUG Adavosertib
Study Locations (20)
California
- UC Irvine Health/Chao Family Comprehensive Cancer Center - Orange
- University of California Davis Comprehensive Cancer Center - Sacramento
- UCSF Medical Center-Mount Zion - San Francisco
- UCSF Medical Center-Mission Bay - San Francisco
Illinois
- Northwestern University - Chicago
- University of Chicago Comprehensive Cancer Center - Chicago
- UC Comprehensive Cancer Center at Silver Cross - New Lenox
- University of Chicago Medicine-Orland Park - Orland Park
Massachusetts
- Massachusetts General Hospital Cancer Center - Boston
- Brigham and Women's Hospital - Boston
- Beth Israel Deaconess Medical Center - Boston
- Dana-Farber Cancer Institute - Boston
Kansas
- University of Kansas Clinical Research Center - Fairway
- University of Kansas Cancer Center - Kansas City
- University of Kansas Hospital-Westwood Cancer Center - Westwood
Michigan
- Wayne State University/Karmanos Cancer Institute - Detroit
- Weisberg Cancer Treatment Center - Farmington Hills
District of Columbia
- MedStar Georgetown University Hospital - Washington D.C.
Maryland
- Johns Hopkins University/Sidney Kimmel Cancer Center - Baltimore
Missouri
- Siteman Cancer Center at Saint Peters Hospital - City of Saint Peters
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2019-01-29 |
| Est. Completion | 2026-03-01 |
| Phase | Phase 2 |
What the registry record for NCT03284385 still lists
NCT03284385 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 206-participant average among 92 other Metastatic Malignant Solid Neoplasm trials with a reported enrollment target (71% lower).
The record links to 7 conditions, with Metastatic Malignant Solid Neoplasm appearing as the primary indexed condition, and to 1 intervention - of which Adavosertib is the first listed.
NCT03284385 names 20 study sites across 8 states, led by California, Illinois, Massachusetts.
Frequently Asked Questions
What is clinical trial NCT03284385 about?
NCT03284385 is a clinical study titled "Testing AZD1775 in Advanced Solid Tumors That Have a Mutation Called SETD2". This phase II trial studies how well adavosertib works in treating patients with SETD2-deficient solid tumors that have spread to other places in the body (advanced/metastatic). Adavosertib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
What is the current status of trial NCT03284385?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 60 participants. The study started on 2019-01-29. Estimated completion is 2026-03-01.
What conditions does trial NCT03284385 study?
This clinical trial studies the following conditions: Metastatic Malignant Solid Neoplasm, Clear Cell Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma, Stage IV Renal Cell Cancer AJCC v8, Stage III Renal Cell Cancer AJCC v8.
What interventions are being tested in trial NCT03284385?
The interventions under investigation include: Adavosertib (DRUG).
Who is sponsoring clinical trial NCT03284385?
This trial is sponsored by National Cancer Institute (NCI), which has 3,257 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03284385 being conducted?
This trial has 20 study locations across California, District of Columbia, Illinois, Kansas, Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Metastatic Malignant Solid Neoplasm
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03284385's enrollment target sits among peer trials
60 45th of 92 higher than 48 of 92 other Metastatic Malignant Solid Neoplasm trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Metastatic Malignant Solid Neoplasm trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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