Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 1

Cabozantinib S-Malate in Treating Patients With Advanced Solid Tumors and Human Immunodeficiency Virus

NCT01822522 · View on ClinicalTrials.gov ↗

Study Summary

This phase I trial studies the side effects and best dose of cabozantinib s-malate in treating patients with solid tumors that have spread to other places in the body and usually cannot be cured or controlled with treatment and human immunodeficiency virus. Cabozantinib s-malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Interventions

  • DRUG Cabozantinib S-malate
  • OTHER Laboratory Biomarker Analysis
  • OTHER Pharmacological Study

Study Locations (20)

California

  • UC San Diego Moores Cancer Center — La Jolla
  • UCLA Center for Clinical AIDS Research and Education — Los Angeles
  • UCLA / Jonsson Comprehensive Cancer Center — Los Angeles
  • UC San Diego Medical Center - Hillcrest — San Diego

New York

  • Montefiore Medical Center-Einstein Campus — The Bronx
  • Montefiore Medical Center-Weiler Hospital — The Bronx
  • Montefiore Medical Center - Moses Campus — The Bronx

Texas

  • Thomas Street Clinic — Houston
  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center — Houston
  • Ben Taub General Hospital — Houston

Washington

  • Virginia Mason Medical Center — Seattle
  • Harborview Medical Center — Seattle
  • Fred Hutchinson Cancer Research Center — Seattle

Missouri

  • Siteman Cancer Center at Washington University — St Louis
  • Washington University School of Medicine — St Louis

Hawaii

  • University of Hawaii Cancer Center — Honolulu

Louisiana

  • Louisiana State University — Lafayette

Maryland

  • Johns Hopkins University/Sidney Kimmel Cancer Center — Baltimore

Trial Details

FieldValue
Enrollment Target 36 participants
Start Date 2013-06-21
Est. Completion 2021-05-12
Phase Phase 1

Sponsor

National Cancer Institute (NCI)

2,390 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT01822522

The ClinicalTrials.gov registry entry for NCT01822522 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 36 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 5 conditions, with Advanced Malignant Solid Neoplasm appearing as the primary indexed condition, and to 3 interventions — of which Cabozantinib S-malate is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT01822522 reports 20 study locations spanning 10 distinct geographic areas — top geographies include California, New York, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT01822522 about?

NCT01822522 is a clinical study titled "Cabozantinib S-Malate in Treating Patients With Advanced Solid Tumors and Human Immunodeficiency Virus". This phase I trial studies the side effects and best dose of cabozantinib s-malate in treating patients with solid tumors that have spread to other places in the body and usually cannot be cured or controlled with treatment and human immunodeficiency virus. Cabozantinib s-malate may stop the growth ...

What is the current status of trial NCT01822522?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 36 participants. The study started on 2013-06-21. Estimated completion is 2021-05-12.

What conditions does trial NCT01822522 study?

This clinical trial studies the following conditions: Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm, HIV Infection, Recurrent Malignant Solid Neoplasm, Unresectable Solid Neoplasm. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT01822522?

The interventions under investigation include: Cabozantinib S-malate (DRUG), Laboratory Biomarker Analysis (OTHER), Pharmacological Study (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT01822522?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT01822522 being conducted?

This trial has 20 study locations across California, Hawaii, Louisiana, Maryland, Massachusetts. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial