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ClinicalTrials.gov 18 recruiting now official registry

Metastatic Malignant Neoplasm in the Brain clinical trials

Every US clinical trial registered for Metastatic Malignant Neoplasm in the Brain — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

44 US clinical trials · 18 currently recruiting

The research picture

Metastatic Malignant Neoplasm in the Brain has 44 registered US clinical trials, 18 of them open to new participants right now — about 41% of the total.

18
recruiting participants now
41%
of trials open to enrollment
10
in Phase 3–4 (later-stage)
13
top sponsor: M.D. Anderson Cancer Center

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 3 491 participants

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

SWOG Cancer Research Network

NCT03418961

RECRUITING Phase 3 269 participants

Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain

NRG Oncology

NCT06500455

RECRUITING 200 participants

Patient Perceptions Around Quality of Care Through Telemedicine in Neuro-Oncology

M.D. Anderson Cancer Center

NCT04988009

RECRUITING Phase 3 200 participants

Testing if High Dose Radiation Only to the Sites of Brain Cancer Compared to Whole Brain Radiation That Avoids the Hippocampus is Better at Preventing Loss of Memory and Thinking Ability

NRG Oncology

NCT04804644

RECRUITING Phase 3 180 participants

Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases

M.D. Anderson Cancer Center

NCT03741673

RECRUITING Phase 2 150 participants

Gadolinium and Ferumoxytol MRI in Diagnosing Patients With Abnormalities in the Central Nervous System

OHSU Knight Cancer Institute

NCT03270059

RECRUITING Phase 3 140 participants

Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors

Mayo Clinic

NCT03750227

RECRUITING Phase 2 112 participants

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

SWOG Cancer Research Network

NCT04511013

RECRUITING NA 100 participants

Feasibility of Intraoperative Microdialysis During Neurosurgery for Central Nervous System Malignancies

Mayo Clinic

NCT04047264

RECRUITING NA 90 participants

Neurocognition in Patients With Multiple Brain Metastases Treated With Radiosurgery

Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University

NCT03184038

RECRUITING NA 75 participants

Electrocorticography in Mapping Functional Brain Areas During Surgery in Patients With Brain Tumors

M.D. Anderson Cancer Center

NCT02754544

RECRUITING Phase 2 69 participants

SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial

Mayo Clinic

NCT05222620

RECRUITING NA 42 participants

Advanced Magnetic Resonance Imaging for the Identification of Recurrent Brain Tumors and Radiation Necrosis

Jonsson Comprehensive Cancer Center

NCT07339085

RECRUITING Phase 1 30 participants

Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain

Kari Kendra

NCT05588453

RECRUITING Phase 2 23 participants

Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast Cancer or HER2+ Breast Cancer

Roswell Park Cancer Institute

NCT04348747

RECRUITING Phase 1 20 participants

Zr-89 Crefmirlimab Berdoxam and Immuno-Positron Emission Tomography for the Imaging of Patients With Resectable Brain Tumors

Jonsson Comprehensive Cancer Center

NCT06650163

RECRUITING Phase 4 10 participants

An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis

City of Hope Medical Center

NCT05376878

RECRUITING Early Phase 1 10 participants

Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases

Emory University

NCT06328686

ACTIVE NOT RECRUITING Phase 3 242 participants

Single Fraction Stereotactic Radiosurgery Compared With Fractionated Stereotactic Radiosurgery in Treating Patients With Resected Metastatic Brain Disease

Alliance for Clinical Trials in Oncology

NCT04114981

ACTIVE NOT RECRUITING Phase 3 237 participants

Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases

NRG Oncology

NCT05438212

ACTIVE NOT RECRUITING Phase 3 132 participants

Stereotactic Radiosurgery Compared to Observation in Treating Patients With Brain Metastases

M.D. Anderson Cancer Center

NCT00950001

ACTIVE NOT RECRUITING Phase 2 110 participants

Neuropsychological Care for Maintaining Quality of Life After Radiation Therapy in Patients With Brain Metastases

Ohio State University Comprehensive Cancer Center

NCT05503251

ACTIVE NOT RECRUITING Phase 3 88 participants

Stereotactic Radiosurgery or Whole Brain Radiation Therapy in Treating Patients With Newly Diagnosed Non-melanoma Brain Metastases

M.D. Anderson Cancer Center

NCT01592968

ACTIVE NOT RECRUITING Phase 1 80 participants

Nivolumab and Radiation Therapy With or Without Ipilimumab in Treating Patients With Brain Metastases From Non-small Cell Lung Cancer

M.D. Anderson Cancer Center

NCT02696993

ACTIVE NOT RECRUITING NA 74 participants

Mind-Body Intervention in Glioma Couples

M.D. Anderson Cancer Center

NCT03244995

ACTIVE NOT RECRUITING Phase 2 55 participants

Stereotactic Radiosurgery for the Treatment of Patients With Small Cell Lung Cancer Brain Metastasis

M.D. Anderson Cancer Center

NCT04516070

ACTIVE NOT RECRUITING Phase 2 52 participants

Nivolumab With Trametinib and Dabrafenib, or Encorafenib and Binimetinib in Treating Patients With BRAF Mutated Metastatic or Unresectable Stage III-IV Melanoma

M.D. Anderson Cancer Center

NCT02910700

ACTIVE NOT RECRUITING Phase 2 49 participants

Stereotactic Radiosurgery in Treating Patients With Greater Than 3 Melanoma Brain Metastases

M.D. Anderson Cancer Center

NCT01644591

ACTIVE NOT RECRUITING Phase 2 44 participants

Testing Sacituzumab Govitecan Therapy in Patients With HER2-Negative Breast Cancer and Brain Metastases

SWOG Cancer Research Network

NCT04647916

ACTIVE NOT RECRUITING Phase 2 29 participants

Bevacizumab and Atezolizumab With or Without Cobimetinib in Treating Patients With Untreated Melanoma Brain Metastases

M.D. Anderson Cancer Center

NCT03175432

ACTIVE NOT RECRUITING Early Phase 1 26 participants

Radiosurgery Before Surgery for the Treatment of Brain Metastases

Emory University

NCT04895592

ACTIVE NOT RECRUITING Phase 2 26 participants

Low Dose Versus Standard Dose Dexamethasone for Reduction of Swelling in Patients with Primary or Metastatic Brain Tumors

City of Hope Medical Center

NCT05139043

ACTIVE NOT RECRUITING Phase 1 24 participants

HER2-CAR T Cells in Treating Patients With Recurrent Brain or Leptomeningeal Metastases

City of Hope Medical Center

NCT03696030

ACTIVE NOT RECRUITING Phase 1 22 participants

Testing of the Anti Cancer Drugs CB-839 HCl (Telaglenastat) and MLN0128 (Sapanisertib) in Advanced Stage Non-small Cell Lung Cancer

National Cancer Institute (NCI)

NCT04250545

ACTIVE NOT RECRUITING NA 22 participants

nTMS in Planning Stereotactic Radiosurgery in Patients With Brain Metastases in the Motor Cortex

M.D. Anderson Cancer Center

NCT04062305

ACTIVE NOT RECRUITING Phase 1 15 participants

Testing the Safety of M6620 (VX-970) When Given With Standard Whole Brain Radiation Therapy for the Treatment of Brain Metastases From Non-small Cell Lung Cancer, Small Cell Lung Cancer, or Neuroendocrine Tumors

National Cancer Institute (NCI)

NCT02589522

ACTIVE NOT RECRUITING Phase 1 11 participants

Ropidoxuridine and Whole Brain Radiation Therapy in Treating Patients With Brain Metastases

National Cancer Institute (NCI)

NCT02993146

ACTIVE NOT RECRUITING Phase 1 10 participants

Trametinib With or Without Whole Brain Radiation Therapy in Treating Patients With Brain Metastases

National Cancer Institute (NCI)

NCT02015117

ACTIVE NOT RECRUITING Phase 2 7 participants

Osimertinib With or Without Bevacizumab in Treating Patients With EGFR Positive Non-small Cell Lung Cancer and Brain Metastases

National Cancer Institute (NCI)

NCT02971501

ACTIVE NOT RECRUITING Phase 1 1 participants

Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-200M for the Treatment of Melanoma Brain Metastases

Emory University

NCT05341349

COMPLETED NA 155 participants

Ferumoxytol in Improving MR Imaging in Patients With High-Grade Brain Tumors or Cerebral Metastases

OHSU Knight Cancer Institute

NCT00103038

COMPLETED 54 participants

Blood Brain Barrier Differences in Patients with Brain Tumors Undergoing Surgery

Mayo Clinic

NCT03071913

COMPLETED Phase 1 8 participants

STAT3 Inhibitor WP1066 in Treating Patients With Recurrent Malignant Glioma or Progressive Metastatic Melanoma in the Brain

M.D. Anderson Cancer Center

NCT01904123

COMPLETED Phase 1 3 participants

Testing the Addition of an Anti-cancer Drug, Entinostat, to the Usual Chemotherapy and Immunotherapy Treatment (Atezolizumab, Carboplatin and Etoposide) for Previously Untreated Aggressive Lung Cancer That Has Spread

National Cancer Institute (NCI)

NCT04631029

Phase Distribution

PhaseTrial count
Phase 1 13
Phase 2 12
Phase 3 9
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Metastatic Malignant Neoplasm in the Brain Trial Landscape

ClinicalTrials.gov lists 44 US studies indexed under Metastatic Malignant Neoplasm in the Brain, and 18 of those are currently open to recruitment — roughly 41% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Metastatic Malignant Neoplasm in the Brain shows 10 late-stage studies (Phase 3 and Phase 4 combined) alongside 25 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Metastatic Malignant Neoplasm in the Brain is led by M.D. Anderson Cancer Center with 13 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 44 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Metastatic Malignant Neoplasm in the Brain?

PlainTrial tracks 44 US clinical trials for Metastatic Malignant Neoplasm in the Brain, of which 18 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Metastatic Malignant Neoplasm in the Brain?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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