Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING Phase 1

Ropidoxuridine and Whole Brain Radiation Therapy in Treating Patients With Brain Metastases

NCT02993146 · View on ClinicalTrials.gov ↗

Study Summary

This phase I trial studies the side effects and best dose of ropidoxuridine when given together with whole brain radiation therapy in treating patients with cancer that has spread to the brain (brain metastases). Ropidoxuridine may help whole brain radiation therapy work better by making cancer cells more sensitive to the radiation therapy.

Interventions

  • OTHER Quality-of-Life Assessment
  • OTHER Laboratory Biomarker Analysis
  • OTHER Pharmacological Study
  • RADIATION Whole-Brain Radiotherapy
  • DRUG Ropidoxuridine

Study Locations (14)

Michigan

  • University of Michigan Comprehensive Cancer Center — Ann Arbor
  • Wayne State University/Karmanos Cancer Institute — Detroit
  • Weisberg Cancer Treatment Center — Farmington Hills

Texas

  • UT Southwestern/Simmons Cancer Center-Dallas — Dallas
  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center — Houston
  • Ben Taub General Hospital — Houston

California

  • UC San Diego Moores Cancer Center — La Jolla
  • University of California Davis Comprehensive Cancer Center — Sacramento

Iowa

  • University of Iowa/Holden Comprehensive Cancer Center — Iowa City

Maryland

  • University of Maryland/Greenebaum Cancer Center — Baltimore

Nebraska

  • University of Nebraska Medical Center — Omaha

New York

  • NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center — New York

Pennsylvania

  • Fox Chase Cancer Center — Philadelphia

Trial Details

FieldValue
Enrollment Target 11 participants
Start Date 2017-05-08
Est. Completion 2026-10-03
Phase Phase 1

Sponsor

National Cancer Institute (NCI)

2,390 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02993146

The ClinicalTrials.gov registry entry for NCT02993146 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 11 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Malignant Solid Neoplasm appearing as the primary indexed condition, and to 5 interventions — of which Quality-of-Life Assessment is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02993146 reports 14 study locations spanning 9 distinct geographic areas — top geographies include Michigan, Texas, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02993146 about?

NCT02993146 is a clinical study titled "Ropidoxuridine and Whole Brain Radiation Therapy in Treating Patients With Brain Metastases". This phase I trial studies the side effects and best dose of ropidoxuridine when given together with whole brain radiation therapy in treating patients with cancer that has spread to the brain (brain metastases). Ropidoxuridine may help whole brain radiation therapy work better by making cancer cell...

What is the current status of trial NCT02993146?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 11 participants. The study started on 2017-05-08. Estimated completion is 2026-10-03.

What conditions does trial NCT02993146 study?

This clinical trial studies the following conditions: Malignant Solid Neoplasm, Hematopoietic and Lymphoid Cell Neoplasm, Metastatic Malignant Neoplasm in the Brain. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02993146?

The interventions under investigation include: Quality-of-Life Assessment (OTHER), Laboratory Biomarker Analysis (OTHER), Pharmacological Study (OTHER), Whole-Brain Radiotherapy (RADIATION), Ropidoxuridine (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02993146?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02993146 being conducted?

This trial has 14 study locations across California, Iowa, Maryland, Michigan, Nebraska. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial