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ClinicalTrials.gov 17 recruiting now official registry

Castration-Resistant Prostate Carcinoma clinical trials

17 of 44 indexed Castration-Resistant Prostate Carcinoma trials are currently recruiting.

44 US clinical trials · 17 currently recruiting

Castration-Resistant Prostate Carcinoma is the subject of 44 registered US clinical trials on ClinicalTrials.gov, 17 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 40 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 6 of these trials.

The research picture

Castration-Resistant Prostate Carcinoma has 44 registered US clinical trials, 17 of them open to new participants right now, about 39% of the total.

17
recruiting participants now
39%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
6
top sponsor: M.D. Anderson Cancer Center
Phase 115Phase 225Phase 32

Active & Recent Trials

44 total, page 1 of 1

RECRUITING Phase 3 528 participants

Testing Whether the Addition of Carboplatin Chemotherapy to Cabazitaxel Chemotherapy Will Improve Outcomes Compared to Cabazitaxel Alone in People With Castrate-Resistant Prostate Cancer That Has Spread Beyond the Prostate to Other Parts of the Body

SWOG Cancer Research Network

NCT06470243

RECRUITING Phase 2 474 participants

Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

Alliance for Clinical Trials in Oncology

NCT06632977

RECRUITING Phase 2 236 participants

Schedule De-Escalation of 177Lu-PSMA-617 for the Treatment of Metastatic Castrate Resistant Prostate Cancer

Mayo Clinic

NCT06200103

RECRUITING Phase 2 69 participants

Supraphysiological Androgen to Enhance Treatment Activity in Metastatic Castration-Resistant Prostate Cancer, SPECTRA Study

University of Washington

NCT06039371

RECRUITING Phase 1 56 participants

Imaging of Solid Tumors Using 18F-TRX

Rahul Aggarwal

NCT06942104

RECRUITING 48 participants

Impact of DNA Repair Pathway Alterations on Sensitivity to Radium-223 in Bone Metastatic Castration-resistant Prostate Cancer

University of Washington

NCT04489719

RECRUITING Phase 1 48 participants

Cell Therapy (STEAP1 CART) With Enzalutamide for the Treatment of Patients With Metastatic Castration-Resistant Prostate Cancer

Fred Hutchinson Cancer Center

NCT06236139

RECRUITING NA 40 participants

Cryoablation Combined With Stereotactic Body Radiation Therapy for the Treatment of Painful Bone Metastases, the CROME Trial

M.D. Anderson Cancer Center

NCT04693377

RECRUITING Phase 2 40 participants

Re-treatment With 177Lu-PSMA-617 for the Treatment of Metastatic Castration-Resistant Prostate Cancer, RE-LuPSMA Trial

Jonsson Comprehensive Cancer Center

NCT06288113

RECRUITING Phase 1 39 participants

Ruxolitinib and Enzalutamide for the Treatment of Metastatic Castration-Resistant Prostate Cancer

University of Michigan Rogel Cancer Center

NCT06616155

RECRUITING Phase 2 36 participants

Measuring the Effects of Talazoparib in Patients With Advanced Cancer and DNA Repair Variations

National Cancer Institute (NCI)

NCT04550494

RECRUITING Phase 2 33 participants

Cabozantinib and Atezolizumab for the Treatment of Metastatic Castration-Resistant Prostate Cancer, The AtezoCab Trial

University of Utah

NCT05168618

RECRUITING Phase 1 30 participants

Image-Guided Biopsies to Identify Mechanisms of Resistance in Patients With Metastatic Castration Resistant Prostate Cancer Treated With 177Lu-PSMA Radioligand Therapy

Jonsson Comprehensive Cancer Center

NCT05398302

RECRUITING Phase 1 30 participants

Abemaciclib Before 177Lu-PSMA-617 for the Treatment of Metastatic Castrate Resistant Prostate Cancer

Vadim S Koshkin

NCT05113537

RECRUITING Phase 1 21 participants

PSCA-Targeting CAR-T Cells Plus or Minus Radiation for the Treatment of Patients With PSCA+ Metastatic Castration-Resistant Prostate Cancer

City of Hope Medical Center

NCT05805371

RECRUITING Phase 2 15 participants

Vorinostat and 177Lu-PSMA-617 for the Treatment of PSMA-Low Metastatic Castration-Resistant Prostate Cancer

Fred Hutchinson Cancer Center

NCT06145633

RECRUITING Phase 1 14 participants

Bipolar Androgen Therapy to Restore Sensitivity to Androgen Deprivation Therapy for Patients With Metastatic Castration Resistant Prostate Cancer

Roswell Park Cancer Institute

NCT06305598

ACTIVE NOT RECRUITING Phase 2 223 participants

Abiraterone Acetate and Antiandrogen Therapy With or Without Cabazitaxel and Prednisone in Treating Patients With Metastatic, Castration-Resistant Prostate Cancer Previously Treated With Docetaxel

ECOG-ACRIN Cancer Research Group

NCT03419234

ACTIVE NOT RECRUITING Phase 2 196 participants

Abiraterone Acetate, Prednisone, and Apalutamide With or Without Ipilimumab or Cabazitaxel and Carboplatin in Treating Patients With Metastatic Castration-Resistant Prostate Cancer

M.D. Anderson Cancer Center

NCT02703623

ACTIVE NOT RECRUITING Phase 1 173 participants

Avelumab, Utomilumab, Anti-OX40 Antibody PF-04518600, and Radiation Therapy in Treating Patients With Advanced Malignancies

M.D. Anderson Cancer Center

NCT03217747

ACTIVE NOT RECRUITING Phase 1 145 participants

Testing the Safety of Different Doses of Olaparib Given Radium-223 for Men With Advanced Prostate Cancer With Bone Metastasis

National Cancer Institute (NCI)

NCT03317392

ACTIVE NOT RECRUITING Phase 2 120 participants

Cabazitaxel, Carboplatin, and Cetrelimab Followed by Niraparib With or Without Cetrelimab for the Treatment of Aggressive Variant Metastatic Prostate Cancer

M.D. Anderson Cancer Center

NCT04592237

ACTIVE NOT RECRUITING Phase 2 90 participants

Testing Two Oral Drugs Combination (Cediranib and Olaparib) Compared to a Single Drug (Olaparib) for Men With Advanced Prostate Cancer

National Cancer Institute (NCI)

NCT02893917

ACTIVE NOT RECRUITING Phase 2 73 participants

M6620 and Carboplatin With or Without Docetaxel in Treating Patients With Metastatic Castration-Resistant Prostate Cancer

National Cancer Institute (NCI)

NCT03517969

ACTIVE NOT RECRUITING Phase 1 65 participants

DS3201 and Ipilimumab for the Treatment of Metastatic Prostate, Urothelial and Renal Cell Cancers

M.D. Anderson Cancer Center

NCT04388852

ACTIVE NOT RECRUITING Phase 3 61 participants

A Clinical Study Evaluating The Benefit of Adding Rucaparib to Enzalutamide for Men With Metastatic Prostate Cancer That Has Become Resistant To Testosterone-Deprivation Therapy

Alliance for Clinical Trials in Oncology

NCT04455750

ACTIVE NOT RECRUITING Phase 2 61 participants

ZEN-3694, Enzalutamide, and Pembrolizumab for the Treatment of Metastatic Castration-Resistant Prostate Cancer

Rahul Aggarwal

NCT04471974

ACTIVE NOT RECRUITING Phase 2 58 participants

Pembrolizumab in Treating Patients With Metastatic Castration Resistant Prostate Cancer Previously Treated With Enzalutamide

OHSU Knight Cancer Institute

NCT02312557

ACTIVE NOT RECRUITING Phase 1 37 participants

Enzalutamide and Cabazitaxel in Treating Patients With Metastatic, Castration-Resistant Prostate Cancer

OHSU Knight Cancer Institute

NCT02522715

ACTIVE NOT RECRUITING Phase 2 30 participants

Enzalutamide With or Without Radium Ra 223 Dichloride in Patients With Metastatic, Castration-Resistant Prostate Cancer

University of Southern California

NCT03344211

ACTIVE NOT RECRUITING Phase 1 23 participants

PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot Be Removed by Surgery

National Cancer Institute (NCI)

NCT03218826

ACTIVE NOT RECRUITING Phase 2 20 participants

Testing the Effect of M1774 on Hard-to-Treat Refractory SPOP-mutant Prostate Cancer

National Cancer Institute (NCI)

NCT05828082

ACTIVE NOT RECRUITING Phase 1 15 participants

Pembrolizumab With Combination Chemotherapy in Treating Participants With Locally Advanced or Metastatic Small Cell/Neuroendocrine Cancers of Urothelium or Prostate

Jonsson Comprehensive Cancer Center

NCT03582475

ACTIVE NOT RECRUITING Phase 2 15 participants

68Ga-PSMA-11 PET for the Diagnosis of Metastatic Castration Resistant Prostate Cancer

Thomas Hope

NCT04716725

ACTIVE NOT RECRUITING Phase 1 14 participants

PSCA-CAR T Cells in Treating Patients With PSCA+ Metastatic Castration Resistant Prostate Cancer

City of Hope Medical Center

NCT03873805

ACTIVE NOT RECRUITING Phase 2 8 participants

CJNJ-67652000 and Prednisone for Treatment of Metastatic Castration-Resistant Prostate Cancer and SPOP Gene Mutations

Mayo Clinic

NCT05689021

ACTIVE NOT RECRUITING Phase 1 7 participants

Cyclophosphamide and Dexamethasone for the Treatment of Metastatic Castration Resistant Prostate Cancer

Rashmi Verma, MD

NCT05479578

ACTIVE NOT RECRUITING Phase 2 2 participants

Efficacy of Ra-223 in PSMA PET Optimally Selected Patients

University of California, San Francisco

NCT05924672

COMPLETED Phase 2 54 participants

CYT107 After Vaccine Treatment (Provenge®) in Patients With Metastatic Castration-Resistant Prostate Cancer

Fred Hutchinson Cancer Center

NCT01881867

COMPLETED Phase 2 36 participants

Genetic and Molecular Mechanisms in Assessing Response in Patients With Prostate Cancer Receiving Enzalutamide Therapy

OHSU Knight Cancer Institute

NCT02099864

COMPLETED Phase 2 31 participants

Durvalumab and Tremelimumab in Treating Chemotherapy Naive Patients With Metastatic Castration-Resistant Prostate Cancer

M.D. Anderson Cancer Center

NCT03204812

COMPLETED Phase 2 17 participants

Gallium Ga 68-DOTATATE PET/CT in Diagnosing Patients With Metastatic Castration Resistant Prostate Cancer

Emory University

NCT03448458

COMPLETED Phase 2 14 participants

Docetaxel and Carboplatin in Treating Patients With Metastatic, Castration Resistant Prostate Cancer Containing Inactivated Genes in the BRCA 1/2 Pathway

University of Washington

NCT02598895

COMPLETED Phase 2 7 participants

Pertuzumab, Trastuzumab, Hyaluronidase-zzxf and Enzalutamide for Treatment of Metastatic Castration-Resistant Prostate Cancer

Mayo Clinic

NCT05730712

Phase Distribution

PhaseTrial count
Phase 1 15
Phase 2 25
Phase 3 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Castration-Resistant Prostate Carcinoma Trial Landscape

44 indexed Castration-Resistant Prostate Carcinoma studies · 17 recruiting (39%).

Phase mix: 2 late (III/IV) vs 40 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (6 trials), 9 others listed. 44 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Castration-Resistant Prostate Carcinoma?

PlainTrial tracks 44 US clinical trials for Castration-Resistant Prostate Carcinoma, of which 17 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Castration-Resistant Prostate Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.