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NCT05376878 · ClinicalTrials.gov registry record · Phase 4
An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis
A Phase 4 study of Anatomic Stage IV Breast Cancer AJCC v8 and Metastatic Malignant Neoplasm in the Brain, sponsored by City of Hope Medical Center.
- Recruiting
- Registry status
- Phase 4
- Development phase
- 10
- Enrollment target
- 1
- Study location
NCT05376878 is a Phase 4 study of Anatomic Stage IV Breast Cancer AJCC v8 and Metastatic Malignant Neoplasm in the Brain that is actively recruiting participants, run by City of Hope Medical Center. The registered enrollment target is 10 participants, below the 166-participant average among 59 other Anatomic Stage IV Breast Cancer AJCC v8 trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05376878, a Phase 4 study of Anatomic Stage IV Breast Cancer AJCC v8 and Metastatic Malignant Neoplasm in the Brain, is actively recruiting participants, sponsored by City of Hope Medical Center.
- RECRUITING
- Registry status
- Phase 4
- Development phase
- 10 participants
- Enrollment target
- 1
- Study location
Study Summary
This clinical trial examines an investigational scan (64Cu-DOTA-trastuzumab positron emission tomography \[PET\]/magnetic resonance imaging \[MRI\]) in imaging patients with HER2+ breast cancer that has spread to the brain (brain metastasis). Diagnostic procedures, such as 64Cu-DOTA-trastuzumab PET/MRI, may help find HER2+ breast cancer that has spread to the brain and determine whether cancer in the brain takes up trastuzumab, which may predict for response to trastuzumab deruxtecan (the standard of care chemotherapy).
Conditions Studied
Interventions
- PROCEDURE Magnetic Resonance Imaging
- BIOLOGICAL Trastuzumab
- OTHER Copper Cu 64-DOTA-Trastuzumab
- DEVICE Positron Emission Tomography
- BIOLOGICAL Trastuzumab Deruxtecan
Study Locations (1)
California
- City of Hope Medical Center - Duarte
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 10 participants |
| Start Date | 2022-12-21 |
| Est. Completion | 2026-05-26 |
| Phase | Phase 4 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05376878
The ClinicalTrials.gov registry entry for NCT05376878 describes a study currently listed as recruiting, categorized as Phase 4. The registered enrollment target is 10 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 166-participant average among 59 other Anatomic Stage IV Breast Cancer AJCC v8 trials with a reported enrollment target (94% lower). The listed sponsor is City of Hope Medical Center, which has 582 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Anatomic Stage IV Breast Cancer AJCC v8 appearing as the primary indexed condition, and to 5 interventions - of which Magnetic Resonance Imaging is the first listed.
NCT05376878 reports 1 study location spanning 1 distinct geographic area - top geographies include California.
Frequently Asked Questions
What is clinical trial NCT05376878 about?
NCT05376878 is a clinical study titled "An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis". This clinical trial examines an investigational scan (64Cu-DOTA-trastuzumab positron emission tomography \[PET\]/magnetic resonance imaging \[MRI\]) in imaging patients with HER2+ breast cancer that has spread to the brain (brain metastasis). Diagnostic procedures, such as 64Cu-DOTA-trastuzumab PET/...
What is the current status of trial NCT05376878?
This trial is currently recruiting. It is a Phase 4 study. The enrollment target is 10 participants. The study started on 2022-12-21. Estimated completion is 2026-05-26.
What conditions does trial NCT05376878 study?
This clinical trial studies the following conditions: Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Malignant Neoplasm in the Brain, Metastatic Breast Carcinoma.
What interventions are being tested in trial NCT05376878?
The interventions under investigation include: Magnetic Resonance Imaging (PROCEDURE), Trastuzumab (BIOLOGICAL), Copper Cu 64-DOTA-Trastuzumab (OTHER), Positron Emission Tomography (DEVICE), Trastuzumab Deruxtecan (BIOLOGICAL).
Who is sponsoring clinical trial NCT05376878?
This trial is sponsored by City of Hope Medical Center, which has 582 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05376878 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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