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ClinicalTrials.gov 46 recruiting now official registry

Mantle Cell Lymphoma clinical trials

46 of 103 indexed Mantle Cell Lymphoma trials are currently recruiting.

103 US clinical trials · 46 currently recruiting

Mantle Cell Lymphoma is the subject of 103 registered US clinical trials on ClinicalTrials.gov, 46 of them currently open to new participants. 7 are in Phase 3-4 (later-stage) and 86 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 12 of these trials.

The research picture

Mantle Cell Lymphoma has 103 registered US clinical trials, 46 of them open to new participants right now, about 45% of the total.

46
recruiting participants now
45%
of trials open to enrollment
7
in Phase 3–4 (later-stage)
12
top sponsor: M.D. Anderson Cancer Center
Phase 146Phase 240Phase 37

Active & Recent Trials

103 total, page 2 of 3

ACTIVE NOT RECRUITING Phase 1 190 participants

A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)

ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)

NCT03162536

ACTIVE NOT RECRUITING Phase 1 150 participants

NKX019, Intravenous Allogeneic Chimeric Antigen Receptor Natural Killer Cells (CAR NK), in Adults With B-cell Cancers

Nkarta

NCT05020678

ACTIVE NOT RECRUITING Phase 2 131 participants

Ibrutinib, Rituximab, and Consolidation Chemotherapy in Treating Young Patients With Newly Diagnosed Mantle Cell Lymphoma

M.D. Anderson Cancer Center

NCT02427620

ACTIVE NOT RECRUITING Phase 1 125 participants

Study of BGB-11417 Monotherapy in Participants With Relapsed or Refractory Mantle Cell Lymphoma

BeiGene

NCT05471843

ACTIVE NOT RECRUITING Phase 2 120 participants

Study of Iopofosine I-131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) With Expansion in Waldenstrom

Cellectar Biosciences

NCT02952508

ACTIVE NOT RECRUITING Phase 2 113 participants

Ibrutinib and Rituximab in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma or Older Patients With Newly Diagnosed Mantle Cell Lymphoma

M.D. Anderson Cancer Center

NCT01880567

ACTIVE NOT RECRUITING Phase 2 53 participants

Acalabrutinib and Rituximab for the Treatment of Previously Untreated Mantle Cell Lymphoma

M.D. Anderson Cancer Center

NCT04765111

ACTIVE NOT RECRUITING Phase 2 51 participants

Ibrutinib, Rituximab, Venetoclax, and Combination Chemotherapy in Treating Patients With Newly Diagnosed Mantle Cell Lymphoma

M.D. Anderson Cancer Center

NCT03710772

ACTIVE NOT RECRUITING Phase 1 43 participants

Vorinostat for Graft vs Host Disease Prevention in Children, Adolescents and Young Adults Undergoing Allogeneic Blood and Marrow Transplantation

University of Michigan Rogel Cancer Center

NCT03842696

ACTIVE NOT RECRUITING Phase 2 39 participants

Phase II Palbociclib +Ibrutinib in Mantle Cell Lymphoma

Alliance Foundation Trials

NCT03478514

ACTIVE NOT RECRUITING Phase 2 37 participants

Acalabrutinib-Lenalidomide-Rituximab in Patients With Untreated MCL

Weill Medical College of Cornell University

NCT03863184

ACTIVE NOT RECRUITING Phase 1 36 participants

Autologous CD19 CAR-T Cell Therapy (SYNCAR-001) + Orthogonal IL-2 (STK-009) in Subjects With CD19+ Hematologic Malignancies

Synthekine

NCT05665062

ACTIVE NOT RECRUITING Phase 2 33 participants

Ixazomib Citrate and Rituximab in Treating Patients With Indolent B-cell Non-Hodgkin Lymphoma

University of Washington

NCT02339922

ACTIVE NOT RECRUITING Phase 1 30 participants

A Clinical Trial of BP1002 in Patients With Advanced Lymphoid Malignancies

Bio-Path Holdings

NCT04072458

ACTIVE NOT RECRUITING Phase 1 27 participants

Dose Finding Study of Ibrutinib Plus Lenalidomide / Rituximab in Relapsed or Refractory Mantle Cell Lymphoma

Hackensack Meridian Health

NCT02446236

ACTIVE NOT RECRUITING Phase 2 23 participants

Bendamustine, Obinutuzumab, and Venetoclax in Patients With Untreated Mantle Cell Lymphoma

Emory University

NCT03872180

ACTIVE NOT RECRUITING Phase 2 23 participants

Rituximab/Bendamustine + Rituximab/Cytarabine for Mantle Cell Lymphoma

Dana-Farber Cancer Institute

NCT01661881

ACTIVE NOT RECRUITING Phase 1 23 participants

Study to Evaluate the Safety and Preliminary Efficacy of Ibrutinib and Pembrolizumab in Patients With Chronic Lymphocytic Leukemia (CLL) or Mantle Cell Lymphoma (MCL)

Joshua Brody

NCT03153202

ACTIVE NOT RECRUITING Early Phase 1 22 participants

A Pilot "Window-3" Study of Acalabrutinib Plus Rituximab Followed by Brexucabtagene Autoleucel Therapy in Patients With Previously Untreated High-risk Mantle Cell Lymphoma

M.D. Anderson Cancer Center

NCT05495464

ACTIVE NOT RECRUITING Phase 2 22 participants

Trial Evaluating MGTA-456 in Patients With High-Risk Malignancy

Masonic Cancer Center, University of Minnesota

NCT03674411

ACTIVE NOT RECRUITING Phase 2 20 participants

Ibrutinib in Treating Participants With Untreated High Risk Smoldering Mantle Cell Lymphoma

M.D. Anderson Cancer Center

NCT03282396

ACTIVE NOT RECRUITING Phase 1 16 participants

Cytokine-Treated Veto Cells in Treating Patients With Hematologic Malignancies Following Stem Cell Transplant

M.D. Anderson Cancer Center

NCT03622788

ACTIVE NOT RECRUITING Phase 2 12 participants

Acalabrutinib, Umbralisib, and Ublituximab for the Treatment of Previously Untreated Mantle Cell Lymphoma

City of Hope Medical Center

NCT04783415

ACTIVE NOT RECRUITING Phase 2 9 participants

Acalabrutinib for the Treatment of Ibrutinib-Intolerant Mantle Cell Lymphoma

M.D. Anderson Cancer Center

NCT04189757

COMPLETED Phase 3 523 participants

A Study of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib Given in Combination With Bendamustine and Rituximab in Patients With Newly Diagnosed Mantle Cell Lymphoma

Janssen Research & Development

NCT01776840

COMPLETED Phase 3 447 participants

Study of Bendamustine Hydrochloride and Rituximab (BR) Compared With R-CVP or R-CHOP in the First-Line Treatment of Patients With Advanced Indolent Non-Hodgkin's Lymphoma (NHL) or Mantle Cell Lymphoma (MCL) - Referred to as the BRIGHT Study

Teva Branded Pharmaceutical Products R&D

NCT00877006

COMPLETED 174 participants

Collecting and Storing Tissue Samples From Patients With Rare or Cutaneous Non-Hodgkin Lymphoma

Children's Oncology Group

NCT01000753

COMPLETED Phase 2 152 participants

VELCADE in Subjects With Relapsed or Refractory Mantle Cell Lymphoma

Millennium Pharmaceuticals

NCT00063713

COMPLETED Phase 2 151 participants

Bortezomib After Combination Chemotherapy, Rituximab, and an Autologous Stem Cell Transplant in Treating Patients With Mantle Cell Lymphoma

Alliance for Clinical Trials in Oncology

NCT00310037

COMPLETED Phase 1 91 participants

A Study of Zilovertamab Vedotin (MK-2140) (VLS-101) in Participants With Hematologic Malignancies (MK-2140-001)

VelosBio Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)

NCT03833180

COMPLETED Phase 1 66 participants

Ublituximab + Ibrutinib in Select B-cell Malignancies

TG Therapeutics

NCT02013128

COMPLETED Phase 1 60 participants

Fludarabine, Bendamustine, and Rituximab in Treating Participants With Lymphoid Cancers Undergoing Stem Cell Transplant

M.D. Anderson Cancer Center

NCT00880815

COMPLETED Phase 3 54 participants

Study to Assess the Effect of Treatment With Bendamustine in Combination With Rituximab on QT Interval in Patients With Advanced Indolent Non-Hodgkin's Lymphoma (NHL) or Mantle Cell Lymphoma (MCL)

Cephalon

NCT01073163

COMPLETED Phase 2 53 participants

EPOCH-R Chemotherapy Plus Bortezomib to Treat Mantle Cell Lymphoma

National Cancer Institute (NCI)

NCT00114738

COMPLETED Phase 1 50 participants

Oral Clofarabine for Relapsed/Refractory Non-Hodgkin Lymphoma

Massachusetts General Hospital

NCT00644189

COMPLETED Phase 2 50 participants

Phase II Safety and Efficacy Study of Single-agent AT-101 in Patients With Relapsed or Refractory B-cell Malignancies

Ascenta Therapeutics

NCT00275431

COMPLETED Phase 1 45 participants

A Phase I/Ib Safety and Efficacy Study of the PI3K-delta Inhibitor TGR-1202 and Ibrutinib in Patients With CLL or MCL

Dana-Farber Cancer Institute

NCT02268851

COMPLETED NA 45 participants

Evaluating the Feasibility of a Digital Health Coaching Program for Individuals Following CAR T Therapy

Pack Health

NCT05064787

COMPLETED Phase 1 42 participants

VELCADE®-BEAM and Autologous Hematopoietic Stem Cell Transplantation for Non-Hodgkin's Lymphoma, or Mantle Cell Lymphoma

University of Nebraska

NCT00571493

COMPLETED Phase 1 39 participants

Ph I Trial of NAM NK Cells and IL-2 for Adult Pts With MM and NHL

Masonic Cancer Center, University of Minnesota

NCT03019666

COMPLETED Phase 2 36 participants

Phase 2 Trial of Prophylactic Rituximab Therapy for Prevention of CGVHD

Stanford University

NCT00186628

COMPLETED Phase 2 29 participants

Lenalidomide in Comb w/Rituximab for Pts w/CD5+/CD20+ Hem Malignancies Who Relapse/Progress After Rituximab

H. Lee Moffitt Cancer Center and Research Institute

NCT00609869

COMPLETED Phase 2 26 participants

Chemotherapy Plus Vaccination to Treat Mantle Cell Lymphoma

National Cancer Institute (NCI)

NCT00005780

COMPLETED Phase 2 25 participants

Rituximab and Combination Chemotherapy in Treating Patients With Previously Untreated Mantle Cell Lymphoma

University of Miami

NCT00878254

COMPLETED Phase 1 22 participants

Phase 1/2 Study of VSLI Plus Rituximab in Patients With Relapsed and/or Refractory NHL

Acrotech Biopharma

NCT01851551

COMPLETED Phase 2 22 participants

Imexon for Relapsed Follicular and Aggressive Lymphomas

University of Rochester

NCT01314014

COMPLETED Phase 1 18 participants

CLBR001 and SWI019 in Patients With Relapsed / Refractory B-cell Malignancies

Calibr, a division of Scripps Research

NCT04450069

COMPLETED Phase 2 13 participants

Acalabrutinib With Bendamustine / Rituximab Followed by Cytarabine / Rituximab for Untreated Mantle Cell Lymphoma

Washington University School of Medicine

NCT03623373

COMPLETED Phase 1 11 participants

Venetoclax With Obinutuzumab and Magrolimab (VENOM) in Relapsed and Refractory Indolent B-cell Malignancies

National Cancer Institute (NCI)

NCT04599634

COMPLETED NA 10 participants

Adaptive Bridging RT in R/R B-cell Lymphoma (Pre-CAR T)

Massachusetts General Hospital

NCT06004167

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Phase Distribution

PhaseTrial count
Phase 1 46
Phase 2 40
Phase 3 7

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Mantle Cell Lymphoma Trial Landscape

103 indexed Mantle Cell Lymphoma studies · 46 recruiting (45%).

Phase mix: 7 late (III/IV) vs 86 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (12 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Mantle Cell Lymphoma?

PlainTrial tracks 103 US clinical trials for Mantle Cell Lymphoma, of which 46 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Mantle Cell Lymphoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.