Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
CLBR001 and SWI019 in Patients With Relapsed / Refractory B-cell Malignancies
NCT04450069 · View on ClinicalTrials.gov ↗
Study Summary
CLBR001 + SWI019 is an combination investigational immunotherapy being evaluated as a potential treatment for patients diagnosed with B cell malignancies who are refractory or unresponsive to salvage therapy or who cannot be considered for or have progressed after autologous hematopoietic cell transplantation. This first-in-human study will assess the safety and tolerability of CLBR001 + SWI019 and is designed to determine the maximum tolerated dose (MTD) or optimal SWI019 dose (OSD). Patients will be administered a single infusion of CLBR001 cells followed by cycles of SWI019. The study will also assess the pharmacokinetics and pharmacodynamics of CLBR001 + SWI019.
Conditions Studied
Interventions
- COMBINATION_PRODUCT CLBR001 and SWI019
Study Locations (8)
California
- City of Hope National Medical Center — Duarte
- University of California at San Diego — San Diego
Illinois
- University of Chicago — Chicago
Minnesota
- Masonic Cancer Center, University of Minnesota — Minneapolis
New York
- Weill Cornell Medical College - New York Presbyterian Hospital — New York
North Carolina
- Wake Forest Baptist Health — Winston-Salem
Tennessee
- Sarah Cannon Research Institute - Tennessee Oncology — Nashville
Texas
- Sarah Cannon Research Institute - Texas Transplant Institute — San Antonio
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18 participants |
| Start Date | 2020-08-14 |
| Est. Completion | 2024-05-06 |
| Phase | Phase 1 |
Interested in This Trial?
Always speak with your doctor before enrolling in a clinical trial.
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04450069
The ClinicalTrials.gov registry entry for NCT04450069 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 18 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Calibr, a division of Scripps Research, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 10 conditions, with Mantle Cell Lymphoma appearing as the primary indexed condition, and to 1 intervention — of which CLBR001 and SWI019 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04450069 reports 8 study locations spanning 7 distinct geographic areas — top geographies include California, Illinois, Minnesota. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04450069 about?
NCT04450069 is a clinical study titled "CLBR001 and SWI019 in Patients With Relapsed / Refractory B-cell Malignancies". CLBR001 + SWI019 is an combination investigational immunotherapy being evaluated as a potential treatment for patients diagnosed with B cell malignancies who are refractory or unresponsive to salvage therapy or who cannot be considered for or have progressed after autologous hematopoietic cell trans...
What is the current status of trial NCT04450069?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 18 participants. The study started on 2020-08-14. Estimated completion is 2024-05-06.
What conditions does trial NCT04450069 study?
This clinical trial studies the following conditions: Mantle Cell Lymphoma, Waldenstrom Macroglobulinemia, Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL), Follicular Lymphoma (FL). These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04450069?
The interventions under investigation include: CLBR001 and SWI019 (COMBINATION_PRODUCT). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04450069?
This trial is sponsored by Calibr, a division of Scripps Research, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04450069 being conducted?
This trial has 8 study locations across California, Illinois, Minnesota, New York, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How Clinical Trials Work
Understand phases 1-4, trial design, randomization, and the informed consent process.
Patient Rights in Clinical Trials
Your rights as a participant: consent, withdrawal, privacy, and who to contact.
Finding the Right Clinical Trial
A practical guide to searching trials, understanding eligibility, and evaluating options.
All Guides
Browse our complete library of clinical trial educational resources.
Read our methodology — how this data is sourced, computed, and verified.