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COMPLETED Phase 2

Bortezomib After Combination Chemotherapy, Rituximab, and an Autologous Stem Cell Transplant in Treating Patients With Mantle Cell Lymphoma

NCT00310037 · View on ClinicalTrials.gov ↗

Study Summary

This randomized phase II trial studies how well bortezomib works when given after combination chemotherapy, rituximab, and an autologous stem cell transplant in treating patients with mantle cell lymphoma. Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) together with an autologous stem cell transplant may allow more chemotherapy to be given so that more cancer cells are killed. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Giving bortezomib after combination chemotherapy, monoclonal antibody therapy, and an autologous stem cell transplant may kill any remaining cancer cells or keep the cancer from coming back.

Conditions Studied

Interventions

  • DRUG bortezomib

Study Locations (20)

Illinois

  • Illinois CancerCare - Bloomington — Bloomington
  • St. Joseph Medical Center — Bloomington
  • Graham Hospital — Canton
  • Illinois CancerCare - Canton — Canton
  • Illinois CancerCare - Carthage — Carthage
  • Memorial Hospital — Carthage
  • University of Chicago Cancer Research Center — Chicago
  • Eureka Community Hospital — Eureka
  • Illinois CancerCare - Eureka — Eureka
  • Galesburg Clinic, PC — Galesburg
  • Illinois CancerCare - Galesburg — Galesburg
  • Illinois CancerCare - Havana — Havana
  • Mason District Hospital — Havana
  • Illinois CancerCare - Kewanee Clinic — Kewanee
  • Illinois CancerCare - Macomb — Macomb
  • McDonough District Hospital — Macomb
  • Illinois CancerCare - Monmouth — Monmouth
  • OSF Holy Family Medical Center — Monmouth
  • BroMenn Regional Medical Center — Normal

California

  • UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco

Trial Details

FieldValue
Enrollment Target 151 participants
Start Date 2006-06
Est. Completion 2022-06
Phase Phase 2

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00310037

The ClinicalTrials.gov registry entry for NCT00310037 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 151 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Alliance for Clinical Trials in Oncology, which has 147 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Mantle Cell Lymphoma appearing as the primary indexed condition, and to 1 intervention — of which bortezomib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00310037 reports 20 study locations spanning 2 distinct geographic areas — top geographies include Illinois, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00310037 about?

NCT00310037 is a clinical study titled "Bortezomib After Combination Chemotherapy, Rituximab, and an Autologous Stem Cell Transplant in Treating Patients With Mantle Cell Lymphoma". This randomized phase II trial studies how well bortezomib works when given after combination chemotherapy, rituximab, and an autologous stem cell transplant in treating patients with mantle cell lymphoma. Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell...

What is the current status of trial NCT00310037?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 151 participants. The study started on 2006-06. Estimated completion is 2022-06.

What conditions does trial NCT00310037 study?

This clinical trial studies the following conditions: Mantle Cell Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00310037?

The interventions under investigation include: bortezomib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00310037?

This trial is sponsored by Alliance for Clinical Trials in Oncology, which has 147 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00310037 being conducted?

This trial has 20 study locations across California, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial