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COMPLETED Phase 1

Ph I Trial of NAM NK Cells and IL-2 for Adult Pts With MM and NHL

NCT03019666 · View on ClinicalTrials.gov ↗

Study Summary

This is a phase I trial with pilot expansion of HLA-haploidentical or HLA-mismatched related donor nicotinamide expanded-natural killer (NAM-NK) cell based therapy for patients with relapsed or refractory multiple myeloma (MM) or relapsed/refractory CD20-positive non-Hodgkin lymphoma (NHL). The primary endpoint of the study is to determine the maximum tolerated dose (MTD) of NAM-NK cells while maintaining safety.

Interventions

  • BIOLOGICAL Nicotinamide Expanded Haploidentical or Mismatched Related Donor Natural Killer Cells

Study Locations (1)

Minnesota

  • Masonic Cancer Center, University of Minnesota — Minneapolis

Trial Details

FieldValue
Enrollment Target 39 participants
Start Date 2017-10-18
Est. Completion 2022-08-15
Phase Phase 1

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT03019666

The ClinicalTrials.gov registry entry for NCT03019666 describes a study currently listed as completed. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 39 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Masonic Cancer Center, University of Minnesota, which has 154 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 8 conditions, with Multiple Myeloma appearing as the primary indexed condition, and to 1 intervention — of which Nicotinamide Expanded Haploidentical or Mismatched Related Donor Natural Killer Cells is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT03019666 reports 1 study location spanning 1 distinct geographic area — top geographies include Minnesota. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT03019666 about?

NCT03019666 is a clinical study titled "Ph I Trial of NAM NK Cells and IL-2 for Adult Pts With MM and NHL". This is a phase I trial with pilot expansion of HLA-haploidentical or HLA-mismatched related donor nicotinamide expanded-natural killer (NAM-NK) cell based therapy for patients with relapsed or refractory multiple myeloma (MM) or relapsed/refractory CD20-positive non-Hodgkin lymphoma (NHL). The prim...

What is the current status of trial NCT03019666?

This trial is currently completed. It is a Phase 1 study. The enrollment target is 39 participants. The study started on 2017-10-18. Estimated completion is 2022-08-15.

What conditions does trial NCT03019666 study?

This clinical trial studies the following conditions: Multiple Myeloma, Follicular Lymphoma, Non-Hodgkin Lymphoma, Diffuse Large B Cell Lymphoma, Lymphoplasmacytic Lymphoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT03019666?

The interventions under investigation include: Nicotinamide Expanded Haploidentical or Mismatched Related Donor Natural Killer Cells (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT03019666?

This trial is sponsored by Masonic Cancer Center, University of Minnesota, which has 154 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT03019666 being conducted?

This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial