Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 3

A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell Transplant in Pediatric Patients

NCT05711667 · View on ClinicalTrials.gov ↗

Study Summary

This phase III single arm trial determines whether taking prophylactic letermovir will reduce the likelihood of infection with cytomegalovirus (CMV) in children and adolescents after stem cell transplant compared to estimated rate of infection without prophylaxis. The treatments used to prepare for HCT reduce the body's natural infection-fighting ability and increase the likelihood of an infection with a virus called cytomegalovirus. "Prophylaxis" means to take a drug to prevent a disease or side effect. Letermovir is an antiviral drug that stops cytomegalovirus from multiplying and may prevent cytomegalovirus infection and make the disease less severe.

Interventions

  • PROCEDURE Biospecimen Collection
  • DRUG Letermovir

Study Locations (20)

California

  • UCSF Benioff Children's Hospital Oakland — Oakland
  • UCSF Medical Center-Mission Bay — San Francisco

Florida

  • Nemours Children's Clinic-Jacksonville — Jacksonville
  • Nicklaus Children's Hospital — Miami

Michigan

  • Children's Hospital of Michigan — Detroit
  • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital — Grand Rapids

Missouri

  • Children's Mercy Hospitals and Clinics — Kansas City
  • Washington University School of Medicine — St Louis

Tennessee

  • Saint Jude Children's Research Hospital — Memphis
  • The Children's Hospital at TriStar Centennial — Nashville

Alabama

  • Children's Hospital of Alabama — Birmingham

Colorado

  • Children's Hospital Colorado — Aurora

Delaware

  • Alfred I duPont Hospital for Children — Wilmington

Trial Details

FieldValue
Enrollment Target 105 participants
Start Date 2024-07-11
Est. Completion 2029-06-30
Phase Phase 3

Sponsor

Children's Oncology Group

318 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05711667

The ClinicalTrials.gov registry entry for NCT05711667 describes a study currently listed as recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 105 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Children's Oncology Group, which has 318 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Malignant Solid Neoplasm appearing as the primary indexed condition, and to 2 interventions — of which Biospecimen Collection is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05711667 reports 20 study locations spanning 15 distinct geographic areas — top geographies include California, Florida, Michigan. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05711667 about?

NCT05711667 is a clinical study titled "A Study of the Drug Letermovir as Prevention of Cytomegalovirus Infection After Stem Cell Transplant in Pediatric Patients". This phase III single arm trial determines whether taking prophylactic letermovir will reduce the likelihood of infection with cytomegalovirus (CMV) in children and adolescents after stem cell transplant compared to estimated rate of infection without prophylaxis. The treatments used to prepare for ...

What is the current status of trial NCT05711667?

This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 105 participants. The study started on 2024-07-11. Estimated completion is 2029-06-30.

What conditions does trial NCT05711667 study?

This clinical trial studies the following conditions: Malignant Solid Neoplasm, Hematopoietic and Lymphoid Cell Neoplasm. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05711667?

The interventions under investigation include: Biospecimen Collection (PROCEDURE), Letermovir (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05711667?

This trial is sponsored by Children's Oncology Group, which has 318 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05711667 being conducted?

This trial has 20 study locations across Alabama, California, Colorado, Delaware, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial