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ClinicalTrials.gov 11 recruiting now official registry

Malignant Glioma clinical trials

Every US clinical trial registered for Malignant Glioma — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

41 US clinical trials · 11 currently recruiting

The research picture

Malignant Glioma has 41 registered US clinical trials, 11 of them open to new participants right now — about 27% of the total.

11
recruiting participants now
27%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
8
top sponsor: National Cancer Institute (NCI)

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 1 132 participants

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

National Cancer Institute (NCI)

NCT05099003

RECRUITING 120 participants

Mapping of Electrical Properties in the Brain

Mayo Clinic

NCT06470711

RECRUITING 80 participants

Serial Advanced Magnetic Resonance Imaging Scan for Guidance of Personalized Adaptive Radiotherapy for High Grade Glioma

M.D. Anderson Cancer Center

NCT04771806

RECRUITING Phase 1 46 participants

Panitumumab-IRDye800 in Diagnosing Participants With Malignant Glioma Undergoing Surgery

Stanford University

NCT03510208

RECRUITING NA 30 participants

Non-invasive Glioma Characterization Through Molecular Imaging

University of Miami

NCT03684109

RECRUITING Phase 1 28 participants

Preoperative Radiosurgery for the Treatment of High Grade Glioma, NeoGlioma Trial

Mayo Clinic

NCT05030298

RECRUITING Phase 1 21 participants

CARv3-TEAM-E T Cells in Glioblastoma

Marcela V. Maus, M.D.,Ph.D.

NCT05660369

RECRUITING Phase 1 20 participants

Immunotherapy Before and After Surgery for Treatment of Recurrent or Progressive High Grade Glioma in Children and Young Adults

Sabine Mueller, MD, PhD

NCT04323046

RECRUITING Early Phase 1 18 participants

Intratumoral Extracellular Metabolic Impact of DFMO and AMXT 1501 in Patients With Diffuse or High Grade Glioma

Mayo Clinic

NCT05717153

RECRUITING NA 15 participants

Fitness and Nutrition in Glioma

NYU Langone Health

NCT06665373

RECRUITING NA 15 participants

T2 Star Magnetic Resonance Imaging and Biomarker Blood Testing to Predict the Change and Progress of Malignant Gliomas

John M. Buatti

NCT07447531

ACTIVE NOT RECRUITING Phase 2 1,376 participants

Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)

National Cancer Institute (NCI)

NCT03155620

ACTIVE NOT RECRUITING NA 80 participants

Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG

Children's Oncology Group

NCT03033992

ACTIVE NOT RECRUITING Phase 1 78 participants

BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas

University of California, San Francis

NCT03749187

ACTIVE NOT RECRUITING NA 74 participants

Mind-Body Intervention in Glioma Couples

M.D. Anderson Cancer Center

NCT03244995

ACTIVE NOT RECRUITING Phase 1 71 participants

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma

National Cancer Institute (NCI)

NCT02359565

ACTIVE NOT RECRUITING Phase 2 62 participants

Nivolumab in Patients With IDH-Mutant Gliomas With and Without Hypermutator Phenotype

National Cancer Institute (NCI)

NCT03718767

ACTIVE NOT RECRUITING Phase 2 58 participants

Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma

National Cancer Institute (NCI)

NCT03919071

ACTIVE NOT RECRUITING Phase 2 47 participants

Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma

National Cancer Institute (NCI)

NCT04817254

ACTIVE NOT RECRUITING Phase 2 38 participants

Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Malignant Glioma Without H3 K27M or BRAFV600 Mutations

National Cancer Institute (NCI)

NCT03581292

ACTIVE NOT RECRUITING Early Phase 1 36 participants

Simultaneous Multinuclear Metabolic MRI in Newly Diagnosed or Recurrent Glioma

Jonsson Comprehensive Cancer Center

NCT05045027

ACTIVE NOT RECRUITING Phase 1 30 participants

PEP-CMV in Recurrent MEdulloblastoma/Malignant Glioma

Daniel Landi

NCT03299309

ACTIVE NOT RECRUITING Phase 1 29 participants

Memory-Enriched T Cells in Treating Patients With Recurrent or Refractory Grade III-IV Glioma

City of Hope Medical Center

NCT03389230

ACTIVE NOT RECRUITING 25 participants

A Pilot Study Using 18F-DOPA PET-guided Radiotherapy in Gliomas

Mayo Clinic

NCT02104310

ACTIVE NOT RECRUITING Phase 1 18 participants

D2C7-IT With Atezolizumab for Recurrent Gliomas

Darell Bigner

NCT04160494

ACTIVE NOT RECRUITING Phase 2 15 participants

Effect H2 Water on QoL of Patients Receiving Radiotherapy for High Grade Gliomas.

Stony Brook University

NCT04175301

COMPLETED Phase 1 313 participants

Study of Cabiralizumab in Combination With Nivolumab in Patients With Selected Advanced Cancers

Five Prime Therapeutics

NCT02526017

COMPLETED NA 155 participants

Ferumoxytol in Improving MR Imaging in Patients With High-Grade Brain Tumors or Cerebral Metastases

OHSU Knight Cancer Institute

NCT00103038

COMPLETED Phase 2 104 participants

Bevacizumab Plus Irinotecan Plus Carboplatin for Recurrent Malignant Glioma (MG)

Annick Desjardins

NCT00953121

COMPLETED 95 participants

Prognostic Awareness and Patient-Physician Communication in Malignant Glioma

Memorial Sloan Kettering Cancer Center

NCT02023346

COMPLETED Phase 2 91 participants

18F-DOPA-PET in Finding Tumors in Patients With Newly Diagnosed Gliomas Undergoing Radiation Therapy

Mayo Clinic

NCT01991977

COMPLETED Phase 1 84 participants

An Open-label, Phase I/IIa, Dose Escalating Study of 2B3-101 in Patients With Solid Tumors and Brain Metastases or Recurrent Malignant Glioma.

BBB-Therapeutics B.V.

NCT01386580

COMPLETED Phase 1 59 participants

Selinexor in Treating Younger Patients With Recurrent or Refractory Solid Tumors or High-Grade Gliomas

Children's Oncology Group

NCT02323880

COMPLETED Phase 2 36 participants

Tremelimumab and Durvalumab in Combination or Alone in Treating Patients With Recurrent Malignant Glioma

Northwestern University

NCT02794883

COMPLETED Phase 1 33 participants

Antisense102: Pilot Immunotherapy for Newly Diagnosed Malignant Glioma

david andrews

NCT02507583

COMPLETED Phase 1 33 participants

Hypofractionated Stereotactic Irradiation With Nivolumab, Ipilimumab and Bevacizumab in Patients With Recurrent High Grade Gliomas

H. Lee Moffitt Cancer Center and Research Institute

NCT02829931

COMPLETED Phase 1 28 participants

Neo-adjuvant Evaluation of Glioma Lysate Vaccines in WHO Grade II Glioma

Jennie Taylor

NCT02549833

COMPLETED Phase 1 22 participants

AZD8055 for Adults With Recurrent Gliomas

National Cancer Institute (NCI)

NCT01316809

COMPLETED Phase 1 22 participants

Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors

Pediatric Brain Tumor Consortium

NCT03387020

COMPLETED Phase 1 22 participants

Vaccination-Dendritic Cells With Peptides for Recurrent Malignant Gliomas

Frank Lieberman

NCT00766753

COMPLETED Phase 1 18 participants

Safety and Efficacy Study of REOLYSIN® in the Treatment of Recurrent Malignant Gliomas

Oncolytics Biotech

NCT00528684

Phase Distribution

PhaseTrial count
Phase 1 22
Phase 2 9

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Malignant Glioma Trial Landscape

ClinicalTrials.gov lists 41 US studies indexed under Malignant Glioma, and 11 of those are currently open to recruitment — roughly 27% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Malignant Glioma shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 31 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Malignant Glioma is led by National Cancer Institute (NCI) with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 41 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Malignant Glioma?

PlainTrial tracks 41 US clinical trials for Malignant Glioma, of which 11 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Malignant Glioma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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